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Normal forming method for sodium alginate containing three-dimensional scaffold

A technology of sodium alginate and a molding method, applied in the field of bioengineering, can solve problems such as unfavorable promotion and application of three-dimensional printing technology, inactivation of growth factors and cells, harsh molding conditions, etc. mild conditions

Inactive Publication Date: 2016-07-13
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Combining the existing technologies, it is found that these methods have the following disadvantages: the molding conditions are harsh and complicated, and conditions such as high temperature, ultra-low temperature, ultraviolet light irradiation and the use of organic solvents are required. These harsh molding conditions will inevitably inactivate growth factors and cells, and will not Conducive to the popularization and application of 3D printing technology in bone tissue engineering

Method used

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  • Normal forming method for sodium alginate containing three-dimensional scaffold

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Comparison scheme
Effect test

Embodiment 1

[0030] A normal molding method of a three-dimensional support containing sodium alginate, comprising the following steps:

[0031] (1) Preparation of a three-dimensional scaffold containing sodium alginate

[0032] Dissolve 3g of sodium alginate in deionized water to obtain a sodium alginate solution with a mass concentration of 10%, then add 1g of PVA, stir evenly at 90°C as a printing slurry; then use the slurry as a three-dimensional printing slurry, and use the printer ( The Bioscaffolder printer produced by Gesim, Germany) was printed at room temperature to obtain a three-dimensional bracket containing sodium alginate. The specific parameters of the bracket were that the side length of the bottom surface of the bracket was 15 mm, the height was 6 mm, and the row spacing range of the bracket was 1.15 mm;

[0033] (2) Molding

[0034] Soak the printed three-dimensional scaffold containing sodium alginate in a calcium chloride solution with a concentration of 0.5 mol / L over...

Embodiment 2

[0036] A normal molding method of a three-dimensional support containing sodium alginate, comprising the following steps:

[0037] (1) Preparation of a three-dimensional scaffold containing sodium alginate

[0038] Dissolve 4g of sodium alginate in deionized water to obtain a sodium alginate solution with a mass concentration of 10%, then add 1g of bioactive glass and 1.67g of PVA, and stir at 90°C to obtain a slurry; then, use the slurry as a three-dimensional The printed slurry is printed under normal temperature by a printer (the Bioscaffolder printer produced by Gesim, Germany) to obtain a three-dimensional support containing sodium alginate. The distance between bracket rows is 1.15mm;

[0039] (2) Molding

[0040] Soak the printed three-dimensional scaffold containing sodium alginate in a calcium chloride solution with a concentration of 5 mol / L overnight at room temperature, wash three times with deionized water after soaking, and freeze-dry to constant weight to obta...

Embodiment 3

[0043] A normal molding method of a three-dimensional support containing sodium alginate, comprising the following steps:

[0044] (1) Preparation of a three-dimensional scaffold containing sodium alginate

[0045] Dissolve 2g of sodium alginate in deionized water to obtain a sodium alginate solution with a mass concentration of 10%, then add 1g of bioactive glass and 1g of PVA, and stir at 90°C to obtain a slurry; then, use the slurry as a three-dimensional printing The slurry is printed with a printer at room temperature to obtain a three-dimensional support containing sodium alginate. The specific parameters of the three-dimensional support containing sodium alginate are that the side length of the bottom surface of the support is 15 mm, the height is 6 mm, and the row spacing range of the support is 1.15 mm;

[0046] (2) Molding

[0047] Soak the printed three-dimensional scaffold containing sodium alginate in a calcium chloride solution with a concentration of 0.5 mol / L ...

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Abstract

The invention provides a normal forming method for a sodium alginate containing three-dimensional scaffold.The method includes steps: (1) preparation of the sodium alginate containing three-dimensional scaffold, to be more specific, dissolving sodium alginate into a solvent to obtain a sodium alginate solution, adding PVA (polyvinyl alcohol) into the sodium alginate solution, and well mixing at 80-95 DEG C to obtain slurry; taking the slurry as three-dimensional printing slurry to print at the normal temperature to obtain the sodium alginate containing three-dimensional scaffold; (2) forming, to be more specific, soaking the sodium alginate containing three-dimensional scaffold into a calcium salt solution at the normal temperature to react for 10-24h, and performing curing, washing and freeze drying to obtain the sodium alginate containing three-dimensional scaffold.The normal forming method for the sodium alginate containing three-dimensional scaffold is mild in condition and simple in process.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a normal forming method of a three-dimensional support containing sodium alginate. Background technique [0002] Three-dimensional printing technology is a technology based on digital model files, using bondable materials, and selectively accumulating materials layer by layer to finally form a three-dimensional entity of the product. Compared with the traditional bone tissue engineering scaffold construction method, 3D printing technology has incomparable advantages: the three-dimensional structure of the scaffold can be freely designed, the precise shape and size can be obtained by adjusting the processing parameters, the internal fully penetrated pre-vascularized network, and the Controlled porosity and variable and controllable mechanical strength. The development trend of bone tissue engineering requires growth factors and even cells to be blended with materials to pr...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L27/56B29C67/00B33Y10/00
Inventor 阮长顺蒋立新马宇飞潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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