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Quaternary ammonium salinization fluorescence silicon dot and preparation method and application thereof

A quaternary ammonium saltization and fluorescence technology, which is applied in chemical instruments and methods, luminescent materials, organic chemistry, etc., can solve the problems of low bacterial imaging discrimination, drug resistance and antibacterial applications, and low biocompatibility. Good stability, guaranteed safety, and low cytotoxicity

Active Publication Date: 2016-07-20
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a quaternized fluorescent silicon dot to solve the problems of low differentiation and drug resistance in the prior art in terms of bacterial imaging and the biological phase problems in antibacterial applications. Problems such as low capacity and drug resistance

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  • Quaternary ammonium salinization fluorescence silicon dot and preparation method and application thereof
  • Quaternary ammonium salinization fluorescence silicon dot and preparation method and application thereof
  • Quaternary ammonium salinization fluorescence silicon dot and preparation method and application thereof

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Embodiment 1

[0046] The preparation of the water-soluble silicon dots with amino groups on the surface comprises the following steps:

[0047] (1) Be that the mass fraction is 4.65% sodium citrate aqueous solution, pass into nitrogen 5min, remove the oxygen in the solution;

[0048] (2) Add 3-aminopropyl-trimethoxysilane (APTMS) while stirring in the sodium citrate aqueous solution after deoxygenation, and continue stirring for 10 min in a closed state to form a silicon dot precursor solution; APTMS and lemon The mass ratio of the solute sodium citrate in the sodium citrate aqueous solution is 1:4;

[0049] (3) React the mixed system obtained in step (2) at 180° C. for 5 minutes in a microwave reactor to form a silicon dot solution;

[0050] (4) Use a dialysis bag with a molecular weight of 1000 (the dialysate is water) to dialyze the silicon dot solution to obtain pure APTMS silicon dot solution.

Embodiment 2

[0052] The preparation method is the same as that of Example 1, except that in step (3), the reaction temperature is 140° C., and the reaction time is 15 minutes.

Embodiment 3

[0054] The preparation method is the same as in Example 1, except that in step (2), 3-aminopropyl-triethoxysilane (APTES), 3-(2-aminoethylamino)propyltrimethoxy 3-aminopropyl-trimethoxysilane (DAMO) and 3-[2-(2-aminoethylamino) ethylamino] propyltrimethoxysilane (AEEA) respectively replace embodiment 1 APTMS), prepared three different water-soluble silicon dots with amino groups; the mass ratio of organosilane and reducing agent was 1:8.

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Abstract

The invention discloses a quaternary ammonium salinization fluorescence silicon dot which comprises a silicon-containing nanoparticle and alkyl betaine subjected to covalent grafting on the surface of the nanoparticle. The invention also discloses a preparation method of the quaternary ammonium salinization fluorescence silicon dot and application thereof in aspects such as bacteria resistance and bacteria imaging. Compared with the prior art, the invention has the advantages that a silicon dot of which the surface is provided with amino is subjected to quaternary ammonium salinization through a one-step reaction by utilizing the alkyl betaine, high water solubility of the silicon dot is maintained, and the silicon dot is endowed with excellent selective bacteria resistance and bacteria imaging effects. Moreover, the quaternary ammonium salinization silicon dot has the advantages of high purity degree, high stability, low preparation cost and the like, and a fluorescent marker does not need to be added.

Description

technical field [0001] The invention belongs to the technical field of bionano materials, and in particular relates to a quaternized ammonium-salted fluorescent silicon dot and a preparation method and application thereof. Background technique [0002] At the beginning of the 20th century, bacterial infectious diseases were the leading cause of death worldwide. Infectious disease morbidity and mortality have declined dramatically over the past century due to the advent of antimicrobial agents. However, the emergence of bacterial resistance poses a major threat to the use of existing antibiotics. Efforts have been made to address antimicrobial resistance by discovering new antibiotics and chemically modifying existing antimicrobials. Unfortunately, the rate of development of new antimicrobial drugs cannot keep up with the frequency of emergence of drug-resistant pathogenic microorganisms. Studies have shown that antimicrobial nanomaterials do not cause pathogenic bacteria ...

Claims

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Application Information

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IPC IPC(8): C07F7/02A61K31/695C09K11/06A61P31/04
CPCA61K31/695C07F7/025C09K11/06C09K2211/1014
Inventor 吴富根张晓东陈晓凯杨婧婧
Owner SOUTHEAST UNIV
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