Multiple indicator rapid detection method for raw medicinal powder of condensed pill of six drugs with rehmannia

Abstract

The invention relates to a multiple indicator rapid detection method for a raw medicinal powder of a condensed pill of six drugs with rehmannia. The method comprises the steps of: (1) acquiring raw powders of different batches; (2) determining the content of loganin using HPLC, determining water content by a drying method, and determining an extract content by using a cold soak method; (3) collecting near infrared spectrum data of key detection indicators for the raw medicinal powder of condensed pill of six drugs with rehmannia; (4) modeling near-infrared spectrum and preprocessing band spectrum; (5) establishing a rapid detection and correction model of contents of water, extract and loganin in the raw medicinal powder of the condensed pill of six drugs with rehmannia; and (6) using the correction model for the rapid determination of contents of water, extract and loganin in the raw medicinal powder of the condensed pill of six drugs with rehmannia. The present invention introduces the near infrared spectrum technology; and compared with traditional method, the established analytical method can quickly determine whether the quality of raw medicinal powder is qualified and determine whether the raw medicinal powder can enter the subsequent production process, so as to meet the requirements of fast and efficient production.

Description

technical field [0001] The invention belongs to the field of near-infrared detection, and in particular relates to a rapid detection method for crude drug powder of concentrated pills of Liuwei Dihuang Pills. Background technique [0002] Liuwei Dihuang Pill Concentrated Pill is recorded in the first part of the "Chinese Pharmacopoeia" 2010 edition. Its crude drug powder is obtained by mixing the dried mature pulp of Cornus offficinalis Sieb. et Zucc. and the dried rhizome of Dioscorea opposita Thumb. powder. The 2010 edition of "Chinese Pharmacopoeia" records that Liuwei Dihuang Pills have the effect of nourishing yin and nourishing the kidney, and are used for kidney yin deficiency, dizziness and tinnitus, sore waist and knees, bone steaming hot flashes, night sweats and nocturnal emission, and thirst. Since the crude drug powder of Liuwei Dihuang Pill Concentrated Pill is a mixture of Cornus officinalis and Chinese yam, its chemical composition is very complex, mainly in...

AI Technical Summary

Problems solved by technology

However, the traditional detection method is time-consuming and laborious, and it is difficult to be widely used in production practice. Therefore, it is necessary and promising to develop a method that can quickly detect the quality of crude drug powder of Liuwei Dihuang Pill Concentrated Pills for on-site medicinal material screening and overall quality control.

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