Antibacterial peptide gel and preparation method thereof

A peptide gel, antibacterial peptide technology, applied in the field of medicine, can solve the problems of no report, loss of pharmacological effects of drugs, etc., and achieve the effects of good water solubility, strong adhesion, and easy coating

Inactive Publication Date: 2016-07-27
SHANDONG INT BIOTECH PARK DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, some invention patents involve a lot of gel preparation, but there is no report on the modified antimicrobial peptide HC-30 gel product of Qinghuan sea snake antimicrobial peptide Hc-CATH
Polypeptide drugs are easily damaged by strong acids, strong bases, oxidants, and reducing agents, which cause the drugs to lose their original pharmacological effects

Method used

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  • Antibacterial peptide gel and preparation method thereof
  • Antibacterial peptide gel and preparation method thereof
  • Antibacterial peptide gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, an antimicrobial peptide gel, the percentage content of each component is respectively: antimicrobial peptide HC-300.5%, carbomer-9400.5%, azone 2%, glycerin 20%, appropriate amount of triethanolamine, Purified water made up to 100%.

[0027] The above raw materials are prepared according to the following method:

[0028] (1) Weigh Carbomer-940 powder and disperse it into an appropriate amount of purified water, place it overnight, stir evenly, and obtain solution A;

[0029] (2) Weigh the antibacterial peptide HC-30 powder and add it to an appropriate amount of purified water, and thoroughly mix it with ultrasonic treatment to obtain solution B;

[0030] (3) Azone and glycerin are mixed evenly and then slowly added to solution A to obtain solution C;

[0031] (4) Add solution B to solution C, make up purified water, and stir the solution evenly in the same direction;

[0032] (5) Slowly add triethanolamine, stir evenly, adjust the pH to 6, the solution...

Embodiment 2

[0033] Embodiment 2, an antimicrobial peptide gel, the percentage content of each component is respectively: antimicrobial peptide HC-300.5%, carbomer-9400.5%, azone 2%, propylene glycol 20%, appropriate amount of sodium hydroxide , Purified water to make up to 100%.

[0034] The above raw materials are prepared according to the following method:

[0035] (1) Weigh Carbomer-940 powder and disperse it into an appropriate amount of purified water, place it overnight, stir evenly, and obtain solution A;

[0036] (2) Weigh the antibacterial peptide HC-30 powder and add it to an appropriate amount of purified water, and thoroughly mix it with ultrasonic treatment to obtain solution B;

[0037] (3) Azone and propylene glycol are mixed evenly and slowly added to solution A to obtain solution C;

[0038] (4) Add solution B to solution C, make up purified water, and stir the solution evenly in the same direction;

[0039] (5) Slowly add sodium hydroxide, stir evenly, adjust the pH t...

Embodiment 3

[0040] Embodiment 3, an antimicrobial peptide gel, the percentage content of each component is respectively: antimicrobial peptide HC-300.2%, carbomer-9400.25%, azone 1%, propylene glycol 10%, appropriate amount of triethanolamine, Purified water made up to 100%.

[0041] The above raw materials are prepared according to the following method:

[0042] (1) Weigh Carbomer-940 powder and disperse it into an appropriate amount of purified water, place it overnight, stir evenly, and obtain solution A;

[0043] (2) Weigh the powder of antibacterial peptide HC-30 and add it to an appropriate amount of purified water, and thoroughly mix it with ultrasonic treatment to obtain solution B;

[0044] (3) Azone and propylene glycol are mixed evenly and slowly added to solution A to obtain solution C;

[0045] (4) Add solution B to solution C, make up purified water, and stir the solution evenly in the same direction;

[0046] (5) Slowly add triethanolamine, stir evenly, adjust the pH to ...

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Abstract

The invention belongs to the field of gel preparation and relates to high-efficiency bacteriostatic antibacterial peptide HC-30 gel which is modified hydrophis cyanocinctus antibacterial peptide Hc-CATH and a preparation method thereof. The high-efficiency bacteriostatic antibacterial peptide HC-30 gel is prepared from 0.2-0.7% by mass of antibacterial peptide, 0.25-0.5% by mass of a gel base, 1-3% by mass of a transdermal absorption promoter, 10-30% by mass of a humectant and a proper amount of a pH conditioning agent and purified water. The high-efficiency bacteriostatic antibacterial peptide HC-30 gel can be prepared by simple processes, has good stability, is safe and nontoxic, has no irritation, can be easily coated and removed, can fast produce sterilization effects on the skin surface and has an application potential.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a modified antibacterial peptide HC-30 gel of Qinghuan sea snake antibacterial peptide Hc-CATH and a preparation method thereof. Background technique [0002] Cathelicidins are an important family of antimicrobial peptides in vertebrates, which are mainly expressed on the surface of epithelial tissues, such as skin, digestive tract, respiratory tract and reproductive tract, and play an important role in the process of host resistance to microbial infection. [0003] Cathelicidins have broad-spectrum and high-efficiency antimicrobial activity. The antibacterial peptides of the cathelicidins family that have been discovered so far have strong activity against Gram-positive bacteria, Gram-negative bacteria, fungi, molds, mycoplasma, chlamydia, protozoa and some enveloped viruses. On the other hand, antimicrobial peptides of the cathelicidins family have a rapid bactericidal effect, generall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/583A61K38/00A61K9/06A61K47/32A61P31/04
Inventor 赵海婷张淑敏傅风华杨小平吴长景杨雪高久香
Owner SHANDONG INT BIOTECH PARK DEV
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