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Tamarind fruit shell extract, preparing method and application thereof in reducing glycosylated hemoglobin level

A technology of extract and tamarind, which is applied in the field of plant extract and its preparation, can solve the problems of rising blood sugar, prevention and control of diabetic complications, etc., to improve glucose tolerance, improve the level of glycosylated hemoglobin, The effect of inhibiting activity

Inactive Publication Date: 2016-07-27
SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tamarind pulp contains a lot of fructose and sucrose, which can also cause blood sugar to rise to a certain extent, which is of little significance for the prevention and control of diabetic complications

Method used

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  • Tamarind fruit shell extract, preparing method and application thereof in reducing glycosylated hemoglobin level
  • Tamarind fruit shell extract, preparing method and application thereof in reducing glycosylated hemoglobin level
  • Tamarind fruit shell extract, preparing method and application thereof in reducing glycosylated hemoglobin level

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment one: the preparation of tamarind shell ethanol extract

[0020] Accurately weigh 500 g of dried tamarind shells, crush them with a pulverizer, and reclaim the finely powdered tamarind shells, add 10 times the amount of 50v / v% hydrous ethanol, heat and reflux for extraction for 120 minutes, and filter the extract through gauze. Extract once again under the same conditions, then filter through gauze, and combine the two extracts and filtrates. The solvent is recovered from the filtrate to obtain the extract of the tamarind shell ethanol extract.

Embodiment 2

[0021] Embodiment two: the preparation of tamarind shell water extract

[0022] Accurately weigh 500g of dried tamarind shells, crush them with a grinder, and recover the finely powdered tamarind shells, add 5 times the amount of purified water, heat and reflux for extraction for 120 minutes, filter the extract through gauze, and use the same conditions for the filter cake Extract once, then filter through gauze, and combine the two extract filtrates. After the filtrate is concentrated, it is freeze-dried to obtain the extract of the tamarind shell water extract.

Embodiment 3

[0023] Embodiment three: the chemical composition analysis of tamarind shell extract

[0024] Get 240 mg of the ethanol extract extract of Tamarinosa made in Example 1, dissolve it in 5% methanol, and analyze its chemical composition by liquid chromatography-mass spectrometry (LC-MS), wherein the liquid chromatography column adopts Cosmosil 5C18-MS-II chromatographic column (4.6ID×250mm, purchased from Japan Half Well Company), the mobile phase is methanol-water (0.2% HCl). After analysis, it was found that the ethanol extract of tamarind shell contains a large amount of flavonoid active compounds, including quercetin, kaempferol, morin, apigenin, naringenin and luteolin.

[0025] Get the tamarind shell water extract extract prepared in Example 2, and analyze its chemical composition according to the above-mentioned method. After analysis, it was found that the water extract of tamarind shell also contains a large amount of flavonoid active compounds, including quercetin, kae...

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Abstract

The invention discloses tamarind fruit shell extract, and a preparing method and application thereof in reducing the glycosylated hemoglobin level. The tamarind fruit shell extract contains quercetin, kaempferol, morin, apigenin, naringenin, luteolin and other components and can effectively prevent, reduce and treat glycosylated hemoglobin increase to effectively prevent, control and treat diabetes and diabetic complication.

Description

technical field [0001] The invention relates to a plant extract and its preparation method and application, in particular to a tamarind shell extract and its preparation method and application. Background technique [0002] Diabetic complications are the main reasons for reducing the quality of life of diabetic patients and leading to disability and death. Clinical research shows that about 1 / 2 of patients with diabetes already have complications when they are diagnosed with diabetes, and once the complications occur, it is difficult to reverse. Therefore, early prevention and treatment of diabetes complications is of great significance to improve the quality of life of patients and prolong the life of patients . [0003] Glycosylated hemoglobin (HbA1c) is the product of irreversible glycosylation of hemoglobin in red blood cells in the blood, which increases with time during the survival period of more than 120 days of red blood cells. Glycosylation of hemoglobin will red...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P3/10
CPCA61K36/48A61K2236/331A61K2236/333
Inventor 李维熙王文静苏薇薇栗原博袁春平郭静高永坚
Owner SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD