A compound for treating diabetes

A compound and composition technology, applied in the field of treating diabetes compounds, can solve problems such as allergies, and achieve the effects of improving body weight, reducing toxic and side effects, improving blood lipid indexes and oral glucose tolerance
CN103435612BActive Publication Date: 2016-03-09SICHUAN GOODDOCTOR PHARMA GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN GOODDOCTOR PHARMA GRP
Publication Date
2016-03-09

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Abstract

The present invention provides a compound represented by formula I or a pharmaceutically acceptable salt, hydrate or solvate thereof. The present invention also provides new applications of the above compounds or pharmaceutically acceptable salts, hydrates or solvates thereof. The deuterated compound prepared by the present invention can obviously improve the body weight, fasting blood sugar, transaminase and fasting serum insulin of obese patients, improve insulin sensitivity, improve blood lipid index and oral glucose tolerance; this type of compound has good absorption in vivo, high bioavailability, and has It is conducive to the exertion of the drug effect, and the half-life is prolonged, which can reduce the number of administrations, reduce the toxic and side effects, and provide a safe and reliable new choice for clinical drug use. Formula I.
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Description

technical field

[0001] The present invention relates to a compound for treating diabetes. Background technique

[0002] According to statistics, the number of people with diabetes in my country has reached 92.4 million, ranking first in the world (YangW, et al. NEnglJMed, 2010, 362(12): 1090-1101). The cost of diabetes treatment in China is as high as 173.4 billion yuan per year, and the direct medical expenditure caused by diabetes has accounted for 13% of China's total medical expenditure (Alcorn T, et al. Lancet, 2012, 379 (9833): 2227-2228). It can be seen that diabetes not only seriously endangers the health of the people, but also brings a heavy economic burden to the country. Therefore, it is urgent to prevent and treat diabetes.

[0003] According to different etiology and clinical manifestations, diabetes is mainly divided into 4 types: insulin-dependent (type 1), non-insulin-dependent (type 2), malnutrition-related and secondary diabetes. Among them, patients wi...

Claims

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