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A method for separation and identification of volatile chemical components in Danlou tablets

A technology of chemical composition and identification method, applied in the field of drug detection, can solve the problems of unreported volatile components of Danlou Tablets, etc.

Active Publication Date: 2018-05-01
吉林康乃尔药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been relevant literature reports on the volatile components of turmeric, Chuanxiong, and Alisma in Danlou tablets. The volatile oil components in each single drug mainly include phenolic acids, ketones, terpenes, and esters. Cerebrovascular diseases have a certain preventive and therapeutic effect, but there is no research report on the volatile components in Danlou tablets, so the research on the volatile components in Danlou tablets is worthy of attention

Method used

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  • A method for separation and identification of volatile chemical components in Danlou tablets
  • A method for separation and identification of volatile chemical components in Danlou tablets
  • A method for separation and identification of volatile chemical components in Danlou tablets

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Embodiment 1

[0019] 1. Materials and Methods

[0020] 1.1 Materials, reagents and instruments

[0021] Danlou Tablets (Jilin Cornell Pharmaceutical Co., Ltd., batch number: 20140602); Sodium chloride (analytical grade); Ultrapure water; Agilent GC 7890 / MS 5975 gas chromatography-mass spectrometry (Agilent Technology Corporation, USA); Chromatographic data processing system (MSD ChemStation E.02.01, Agilent Technology Corporation, USA); NIST08.L spectral library; HJ-3 magnetic stirring heater (Jintan Medical Instrument Factory); 100 μm polydimethylsiloxane coating solid Phase extraction head (PDMS, Supelco, Bellefonte, Pa); HP-5MS capillary column.

[0022] The n-alkane reference solution C8-C20 was purchased from FLUKA Company of the United States.

[0023] 1.2 Method

[0024] 1.2.1 Extract volatile oil by HS-SPEM method: Take 5 Danlou tablets and pulverize them, put 0.6584g of pulverized samples, 3.6g of saturated sodium chloride and 12mL of water into a 150mL headspace bottle, add a s...

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Abstract

The invention provides an isolation and identification method for volatile chemical ingredients in a salvia-miltiorrhizae and fructus-trichosanthis tablet.The volatile ingredients in the salvia-miltiorrhizae and fructus-trichosanthis tablet is extracted through the headspace solid phase microextraction (HS-SPEM) technology, the main ingredients are isolated, analyzed and identified by combining the gas chromatography mass spectrography (GC-MS) technology and the Kovats retention index (KI), good reproducibility and good reliability are achieved, and the important scientific basis is provided for deeply researching the medicine-effect material basis and improving the quality standard of the salvia-miltiorrhizae and fructus-trichosanthis tablet.

Description

technical field [0001] The invention relates to a drug detection method, in particular to a method for separating and identifying volatile chemical components in Danlou tablets. Background technique [0002] Danlou Tablets are commonly used compound preparations for the clinical treatment of coronary heart disease and angina pectoris. . Danlou Tablets are mainly used to treat chest obstruction and heartache caused by intertwined phlegm and blood stasis. Symptoms include chest tightness, chest pain, breathlessness, dark purple tongue, white and greasy fur, and coronary heart disease angina pectoris with the above syndromes. Among the many medicinal flavors of Danlou tablet compound preparations, Chuanxiong and Yujin all contain volatile components. There have been relevant literature reports on the volatile components of turmeric, Chuanxiong, and Alisma in Danlou tablets. The volatile oil components in each single drug mainly include phenolic acids, ketones, terpenes, and e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 张鹏朱彦于春泉高秀梅张娜李琳高杉吴红华王晓明
Owner 吉林康乃尔药业有限公司