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Polyacid Schiff base compound and its synthesis method and use

A technology of Schiff bases and compounds, applied in the field of polyacid Schiff base compounds and their synthesis, can solve the problems of lack of expansion and the like

Inactive Publication Date: 2016-08-10
KUNMING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past few decades, scientific researchers have done a lot of work in the biomedical research of polyacids and Schiff bases. Numerous compounds with novelty and properties have been reported. However, so far metal-Schiff bases and polyacids have been The work of combining these two fields is far from being developed. Therefore, it is very necessary to develop a compound that can solve the above problems

Method used

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  • Polyacid Schiff base compound and its synthesis method and use
  • Polyacid Schiff base compound and its synthesis method and use
  • Polyacid Schiff base compound and its synthesis method and use

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preparation example Construction

[0022] The preparation method of polyacid Schiff base compound of the present invention is characterized in that comprising the following steps:

[0023] A. Put the ammonium heptamolybdate solution in a container, add 3mol / L hydrochloric acid with a volume ratio of 15:1 to the ammonium heptamolybdate solution dropwise and stir at a speed of 800~1000 rpm 40~80min to obtain solution a;

[0024] B. Then the ammonium heptamolybdate solution with a volume ratio of 10:1 contains the newly prepared [Mn(salpn)(H 2 O)] 2 (ClO 4 ) 2 (0.1mol) methanol solution was added dropwise to solution a, and stirred at 800-1000 rpm for 20-40 minutes at 50-70°C to obtain solution b;

[0025] C. Put the solution b under 150~250W microwave radiation and heat it to 50°C to continue the reaction for 5~7 minutes, filter after cooling, and seal the filtrate with a thin film with small holes for slow volatilization for 7~10 days to obtain massive crystals. Rinse and dry naturally in the air to obtain ...

Embodiment 1

[0033] Add 0.17 g of ammonium heptamolybdate into 15 ml of deionized water and stir at 1000 rpm, then add 1 ml of 3 mol / L hydrochloric acid dropwise into the above solution and stir vigorously for 1 hour. Then, the newly prepared [Mn(salpn)(H 2 O)] 2 (ClO 4 ) 2 (0.90g, 1 mmol) (salpn) methanol solution 5ml was added dropwise to the above solution. After stirring in the Erlenmeyer flask at 60°C for 30 minutes, the resulting brown solution was subjected to 200W microwave irradiation for 6 minutes. After filtration, seal the filtrate with a membrane with small holes for slow evaporation. Blocky crystals were obtained after one week. Rinse with methanol and air dry.

Embodiment 2

[0035] The difference between this embodiment and embodiment 1 is that in step 1, 0.17 g of ammonium heptamolybdate is added to 10 ml of deionized water and stirred at a speed of 800 rpm, and other steps and parameters are the same as in embodiment 1 。

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Abstract

The invention discloses a polyacid Schiff base compound and its synthesis method and use. The polyacid Schiff base compound comprises methylimidazole counter cations and methylimidazole sandwich heteropoly acid fragments and belongs to a single crystal triclinic system. The polyacid Schiff base compound has a structural formula shown in the description. The synthesis method comprises putting an ammonium heptamolybdate solution in a container, dropwisely adding hydrochloric acid into the solution to obtain a solution a, dropwisely adding a new prepared methanol solution of [Mn(salpn)(H2O)]2(ClO4)2 into the solution a to obtain a solution b, carrying out microwave radiation heating for a reaction for 5-7min, carrying out cooling and filtration, sealing the filtrate through a film with pores, carrying out slow volatilization for 7-10 days to obtain blocky crystals, washing the blocky crystals through methanol and carrying out natural drying in air to obtain a desired product. The polyacid Schiff base compound is used in preparation of a drug for resisting cancers. In the novel compound synthesis, a final product is prepared under microwave radiation so that a compound yield is greatly improved. The monocrystalline structure provides novel data for a crystal database. A biological activity test proves that the polyacid fragments further improve antineoplastic effects of a Schiff base precursor.

Description

technical field [0001] The invention belongs to the technical field of chemical compounds, and in particular relates to a polyacid Schiff base compound and its synthesis method and application. Background technique [0002] Malignant tumors are currently one of the most serious diseases that endanger human health, and their mortality rate is second only to cardiovascular diseases. In the past 50 years, through the unremitting efforts of scientists from all over the world, great progress has been made in the basic and clinical aspects of tumor epidemiology, clinical diagnosis and treatment of pathogenesis, but there are still many difficult problems to be solved. At present, the treatment of tumors is mainly surgical treatment, radiotherapy and chemotherapy. With the research on the subcellular level and molecular level of the mechanism of drug action, the discovery of new anticancer drugs, the change of combined drugs and drug routes, chemotherapy has become more and more im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F19/00A61P35/00
CPCC07B2200/13C07F13/005
Inventor 吴琼句红萍陶剑
Owner KUNMING UNIV