Tofacitinib citrate

A technology of cloth citrate and cloth citric acid, which is applied in the field of medicine, can solve the problems of poor viscosity and fluidity, and is not suitable for direct compression, and achieves the effects of good dissolution and dissolution performance, good dissolution rate, and good fluidity.
CN105873931AActive Publication Date: 2016-08-17SUNSHINE LAKE PHARM CO LTD
6 Cites 6 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUNSHINE LAKE PHARM CO LTD
Publication Date
2016-08-17

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

Crystalline particle of tofacitinib citrate, process for the preparation of a crystalline particle of tofacitinib citrate, pharmaceutical composition, substantially pure amorphous form of tofacitinib citrate, process for preparing the substantially pure amorphous form of tofacitinib citrate, and use of the crystalline particle of tofacitinib citrate, and the pharmaceutical composition are provided.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] Cross-Referenced Related Applications

[0002] This application claims the priority of the patent application No. 201310464169.8 submitted to the State Intellectual Property Office of China on October 8, 2013, the entire content of which is cited as a reference. technical field

[0003] The invention relates to the field of medicine, in particular to tofacitinib citrate, more specifically to tofacitinib citrate crystal particles, a preparation method for tofacitinib citrate crystal particles, a pharmaceutical composition and the use. Background technique

[0004] Tofacitinib citrate, also known as 3-[(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- Amino]-piperidin-1-yl]-3-oxo-propionitrile citrate, the structure is as shown in formula (I):

[0005]

[0006] PCT application WO2003048162 discloses a new crystal form of tofacitinib citrate and its preparation method, but the crystal particle size prepared according to the method of WO2003048162 is rela...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More