Preparation method and application of nano-scale MOF (metal-organic framework) material
A metal-organic framework and nanoscale technology, which is applied in the preparation of organic compounds, iron group organic compounds without C-metal bonds, medical preparations of non-active ingredients, etc., can solve unfavorable utilization, poor water solubility, and limitations Transportation and other issues, to achieve the effect of mild process conditions, simple process and high yield
Inactive Publication Date: 2016-09-21
SHANGHAI OCEAN UNIV
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Problems solved by technology
[0005] Looking at the current research situation of MOFs in the field of drug loading, the main factors that limit the application of this material are as follows: the water solubility of the material is not good, which is not conducive to further utilization; most MOFs have a crystal structure, and the particle size is on the micron scale, which limits its application. Transport in the body
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Embodiment 1
[0044] 1. Synthesis of MOFs
[0045] (1) Dissolve 0.187g ferric chloride hexahydrate in 5ml DMF marked as ①, dissolve 0.115g 2-aminoterephthalic acid in 10mL DMF marked as ②, heat to 90°C respectively, and put polytetrafluoroethylene The ethylene reactor was heated in a water bath at 90°C for standby use.
[0046](2) Pour ① and ② into the reaction kettle and mix well, tighten the reaction kettle, and continue heating at 90°C for 40 minutes.
[0047] (3) Then the reactor was opened, 1 mL of glycerin was added as a regulator, the reactor was closed, and the temperature was raised to 100° C. for 4 hours. Take out the reactor, cool to room temperature, centrifuge at 10,000r / min for 20min to separate MOF, wash with DMF, absolute ethanol, and ultrapure water three times, and dry in vacuum at 35°C for 24h to obtain the final product.
[0048] figure 1 This is the electron micrograph of the MOF synthesis sample. The particle size of the MOF material synthesized in this implementati...
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Abstract
The invention relates to a preparation method of a nano-scale MOF (metal-organic framework) material. The method comprises steps as follows: 1) ferric trichloride hexahydrate is dissolved in a DMF (dimethyl formamide) solution; 2) 2-aminoterephthalic acid is dissolved in a DMF solution; 3) the solution prepared in the step 1 and the solution prepared in the step 2 are evenly mixed and subjected to a closed reaction at 90 DEG C in a reaction kettle for 40 min; 4) glycerin is added to the reaction solution in the step 3, and the mixture is heated to 100 DEG C for a reaction for 4 h; 5) a target product is obtained through cooling, centrifugation, separation and drying. Reaction conditions are optimized, the particle size of the MOF material is reduced to 500 nm, meanwhile, the shape and the purity of the material are not changed, original advantages are maintained, so that in-vivo transportation is facilitated, and the material is more suitable to be used as a drug carrier.
Description
technical field [0001] The invention relates to the technical field of nanomedicine, in particular to a preparation method and application of a nanoscale metal-organic framework material. Background technique [0002] Metal-organic frameworks (MOFs), also known as metal-organic coordination polymers (metal-organic coordination, MOCPs), porous coordination polymers (porous coordination polymer, PCP), etc. A porous material formed by infinite coordination. Because of its good characteristics such as regular geometric configuration, adjustable pore size and particle size, huge specific surface area, and exposed unsaturated metal sites, it is widely used in the adsorption and separation of substances, chemical and biocatalysis, and targeted delivery of drugs. It has been well applied in aspects such as release and release, and has attracted extensive attention from researchers in various fields such as materials scientists, chemists, and medical scientists. The research on thi...
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Login to View More IPC IPC(8): C07F15/02A61K47/24
CPCA61K47/24C07C51/418C07F15/025
Inventor 刘克海余倩张亚光韩娟娟胡静邬军文张敏
Owner SHANGHAI OCEAN UNIV