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Virus removal membrane

A virus and removal rate technology, applied in membranes, membrane technology, semi-permeable membrane separation, etc., can solve the problems of lack of filtration efficiency, filtration speed, and insufficient research on the conditions for virus removal, so as to achieve high filtration efficiency and virus removal. High removal effect

Active Publication Date: 2016-09-28
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conditions for ensuring virus removal have not been sufficiently studied, and studies for improving filtration efficiency (filtration throughput, filtration speed) have not been conducted.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0077] (production of membrane to remove virus)

[0078] Cotton linters (average molecular weight 1.44×10 5) and sodium sulfate (KISHIDA CHEMICAL Co., Ltd.) were dissolved in a cuproammonia solution produced by a known method, and filtered to defoam, the concentration of cellulose and the concentration of sodium sulfate as an inorganic salt were as follows Figure 5 and Figure 6 As shown, a spinning stock solution having an ammonia concentration of 4.4% by weight and a copper concentration of 2.7% by weight was obtained. Then, the spinning dope is discharged from the outer spinning outlet of the double-layer ring spinning outlet at 3.0cc / min or 3.65cc / min, and simultaneously the Figure 5 and Figure 6 The internal coagulation liquid of acetone / ammonia / water in the weight ratio shown was discharged at 1.8 cc / min from the central spinning outlet of the double-layer annular spinning nozzle.

[0079] The spinning dope and internal coagulation liquid discharged from the doubl...

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PUM

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Abstract

This virus removal membrane (10) for removing a virus from a protein-containing solution comprises cellulose, and is provided with: a primary-side surface (1) to which the protein-containing solution is supplied; and a secondary-side surface (2) from which a permeate that has permeated through the virus removal membrane (10) is discharged. When a solution including colloidal gold having a diameter of 20 nm is supplied to the virus removal membrane from the primary side, the colloidal gold is captured by the virus removal membrane (10), and the luminance in a cross section of the virus removal membrane (10) is measured, the value obtained by dividing, by the average of the areas of luminance displacement in the spectrum, the standard deviation of said areas, is in the range of 0.01-1.5 inclusive. Furthermore, in the cross section of the virus removal membrane (10), the thicknesses of regions where colloidal gold having a diameter in the range of 20-30 nm inclusive is captured are in the range of 10.0-30.0 Mum inclusive in a wet state.

Description

technical field [0001] The present invention relates to virus-removing membranes for removing viruses from solutions. Background technique [0002] In recent years, in addition to plasma fractionation preparations derived from human blood, measures to improve virus safety have been demanded for biopharmaceuticals. Therefore, pharmaceutical manufacturers have conducted research on introducing a virus removal / inactivation process into the production process. Among them, the method of removing viruses by filtration using a virus-removing membrane is an effective method capable of reducing viruses without denaturing useful proteins. [0003] Among viruses, especially parvoviruses, cases of infection caused by human parvovirus B19 in the field of plasma fractionation preparations were reported; in the field of biopharmaceuticals, the effects of mouse parvoviruses on Chinese hamster ovary (CHO, Chinese Hamster Ovary) cells were reported. Instances of pollution. Parvoviruses, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/06B01D69/08B01D71/10
CPCB01D69/06B01D67/0011B01D67/0013B01D69/02B01D69/087B01D2325/022B01D2325/023B01D2325/04B01D2325/20B01D71/10B01D2325/02832B01D71/78B01D67/00931C07K1/34B01D2325/02B01D2325/02833B01D67/00135B01D69/08B01D65/10G01J1/44G01J2001/444
Inventor 浜本亮本乡智子近雄介
Owner ASAHI KASEI MEDICAL CO LTD
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