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Vitamin D3 calcium carbonate oral cavity instant films and preparation method thereof

A technology of oral instant film and calcium carbonate, which is applied in the field of health products to achieve convenient packaging and transportation, good taste and ideal effect of calcium supplementation

Inactive Publication Date: 2016-10-05
苏州倍肯新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After investigation and research in many literatures, there is no report of calcium supplement products of oral instant film preparations in China so far, so vitamin D 3 The study of making oral instant film preparations from calcium tablets is very important and has far-reaching significance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Vitamin D 3 Preparation of calcium carbonate oral instant film

[0023] (1) Weigh 2 g of sucralose and 2 g of sucrose into deionized water, and stir evenly;

[0024] (2) Weigh 6.5 g of hydroxypropyl methylcellulose E-5, 11.5 g of hydroxypropyl methylcellulose E-50, and 6 g of hydroxypropyl methylcellulose E-15, and add the mixture gradually (1 ) in the mixture, stir well;

[0025] (3) Weigh vitamin D 3 0.01 g, add to the mixture in (2), stir well;

[0026] (4) Weigh 2.5 g of calcium carbonate and add it to the mixture in (3), stir well;

[0027] (5) Weigh food coloring, 12 g glycerin and dissolve in pharmaceutical grade absolute ethanol, add to the mixture of (4), stir evenly, control the temperature at 15-30 ℃, after swelling is complete, degas;

[0028] (6) Coating on a coating machine, drying at 80 °C, controlling the dry film thickness to 40 µm, stripping and cutting to obtain vitamin D 3 Calcium carbonate oral instant film.

Embodiment 2

[0029] Example 2: Vitamin D 3 Preparation of calcium carbonate oral instant film

[0030] (1) Weigh 3 g of aspartame and 5 g of sorbitol into deionized water, and stir evenly;

[0031] (2) Weigh 7.5 g of hydroxypropyl methylcellulose E-5 and 2.5 g of pullulan, gradually add the mixture into the mixture in (1), and stir well;

[0032] (3) Weigh vitamin D 3 0.045 g, add to the mixture in (2), stir well;

[0033] (4) Weigh 8.1 g of calcium carbonate and add it to the mixture in (3), stir well;

[0034] (5) Weigh food coloring, 20 g polyethylene glycol-400 and dissolve in pharmaceutical grade anhydrous ethanol, add to the mixture of (4), stir evenly, control the temperature at 15-30 ℃, after swelling is complete, remove gas;

[0035] (6) Coating on a coating machine, drying at 100 °C, controlling the dry film thickness to 60 µm, stripping and cutting to obtain vitamin D 3 Calcium carbonate oral instant film.

Embodiment 3

[0036] Example 3: Vitamin D 3 Preparation of calcium carbonate oral instant film

[0037] (1) Weigh 5 g of sucralose, 5 g of sucrose, and 10 g of sorbitol into deionized water, and stir evenly;

[0038] (2) Weigh 15 g of hydroxypropyl methylcellulose E-5 and 20 g of hydroxypropyl methylcellulose E-50, gradually add the mixture into the mixture in (1), and stir evenly;

[0039] (3) Weigh vitamin D 3 0.082 g, add to the mixture in (2), stir well;

[0040] (4) Weigh 22.66 g of calcium carbonate and add it to the mixture in (3), stir well;

[0041] (5) Weigh food coloring, 26 g glycerin and dissolve in pharmaceutical grade absolute ethanol, add to the mixture of (4), stir evenly, control the temperature at 15-35 ℃, after the swelling is complete, degas;

[0042] (6) Coating on a coating machine, drying at 110 °C, controlling the dry film thickness to 70 µm, stripping and cutting to obtain vitamin D 3 Calcium carbonate oral instant film.

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PUM

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Abstract

The present invention discloses a preparation method of vitamin D3 calcium carbonate oral cavity instant films. The preparation method comprises the following steps: (1) raw and accessory materials of a sweetener, film-forming materials, a plasticizer, vitamin D3 and calcium carbonate are weighed; (2) the sweetener, film-forming materials and vitamin D3 are successively added into deionized water to be stirred uniformly; and after the mixture is fully dissolved, the calcium carbonate and plasticizer are successively added, the temperature is controlled at 15-40 DEG C, and after the mixture is swollen completely, the mixture is degased; and (3) the degased mixture is subjected to a continuous coating on a coating machine, the films are dried at 80-140 DEG C, the thicknesses of the dried films are controlled at 40-110 [mu]m, and roll-dividing, film stripping, cutting, and aluminum-plastic film packaging are carried out to prepare the vitamin D3 calcium carbonate oral cavity instant film agent. The vitamin D3 calcium carbonate oral cavity instant films are good in mouthfeel, free of water drinking, high in bioavailability, suitable for the consumptions of children, the elderly, etc. and high in medication compliance. In addition, the preparation processes are easy and implementable, short in time-consuming, and low in cost, and have good economic benefits.

Description

technical field [0001] The invention belongs to the field of health care products and relates to a vitamin D 3 The invention discloses a preparation method of a calcium carbonate oral instant film. Background technique [0002] Calcium, known as the "element of life", is one of the most important essential elements for the human body, and is an essential nutrient that constitutes human bones and teeth. Calcium participates in many physiological functions of the human body, and plays a vital role in maintaining the normal functions of human nerves, muscles, skeletal system, cell membranes and capillary permeability. Calcium in the human body generally begins to lose a large amount from the age of 35, that is to say, the density of human bones (that is, the total amount of bone) reaches its peak at the age of 35, and then the total amount of bone will be lost with the years, which will easily cause the bone structure to be fragile, resulting in Osteoporosis, prone to "brittl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/303A23L1/304A23P1/08
Inventor 李浪徐雯马鑫
Owner 苏州倍肯新材料科技有限公司
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