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A kind of forsythin tablet

A technology of forsythin tablet and forsythin, which is applied in the field of medicine, can solve the problems of uneven particle size, complex process, and large dust production, and achieve good stability, simple process, and fast dissolution rate. Effect

Active Publication Date: 2019-05-31
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Although the dry granulation process after micronization of raw materials has been improved to a certain extent, the dry granulation process is complicated, the dust production is large, and the particle size is not uniform, and the surface finish of the pressed tablet is poor.

Method used

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  • A kind of forsythin tablet
  • A kind of forsythin tablet
  • A kind of forsythin tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] Preparation Process:

[0024] Dissolve forsythin in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with lactose, sodium carboxymethyl starch, hard Magnesium fatty acid is mixed evenly and compressed by direct compression technology.

Embodiment 2

[0026]

[0027] Preparation Process:

[0028] Dissolve forsythin in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose and cross-linked polyvinyl chloride The ketone and magnesium stearate are evenly mixed and compressed by direct compression technology.

Embodiment 3

[0030]

[0031] Preparation Process:

[0032] Dissolve forsythin in diethylene glycol monoethyl ether, add hydroxypropyl cellulose, stir to dissolve, then add the prescribed amount of fumed silica for adsorption, and then mix with microcrystalline cellulose and cross-linked polyvinyl chloride The ketone and magnesium stearate are evenly mixed and compressed by direct compression technology.

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a phillygenin tablet. The phillygenin tablet is composed of phillygenin, hydroxy propyl cellulose, diethylene glycol monoethyl ether, fumed silica, a filler, a disintegrant and a lubricant. A preparation method comprises the following steps: dissolving phillygenin and hydroxy propyl cellulose in diethylene glycol monoethyl ether, adding with fumed silica for adsorption, then uniformly mixing with the filler, the disintegrant and the lubricant, and carrying out pressing by adopting a direct tableting technology. The medicine dissolution speed is high, the process is simple, a surfactant does not need to be added, and the micronization treatment is not needed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a forsythinin tablet. Background technique [0002] Forsythia, also known as Eclipta chinensis ("Medicine Properties") and Daqiaozi ("Newly Revised Materia Medica"), is the dry fruit of Forsythia suspense (Thunb.Vahl) of Oleaceae. Bitter and slightly cold, it returns to the lung, heart, and small intestine meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispelling stagnation. Urinary retention due to hot shower. The chemical composition of forsythia is complex and diverse, mainly phenylethyl alcohol and its glycosides, C6-C2 natural alcohols, lignans, in addition to flavonoids, pentacyclic triterpenes, alkaloids, etc. [0003] The molecular formula of forsythiagenin (phillygenin) is C 21 h 24 o 6 , the molecular structure is as follows: [0004] [0005] Forsythiagenin (phillygenin) is a lignan compound monomer extr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/34A61K47/38A61K47/10A61P35/00A61P3/06A61P39/06A61P1/16
Inventor 张贵民郑华孙亚敏
Owner SHANDONG NEWTIME PHARMA