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Composition for preparing hollow capsules of modified starch matrix and hollow capsules

A modified starch and hollow capsule technology, applied in the field of medicine, can solve the problems of unqualified capsule shape, low filling rate, and long disintegration time, so as to improve the filling rate, maintain flexibility and strength, and extend the shelf life.

Active Publication Date: 2019-08-16
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent CN104055748A discloses a composition for preparing hard capsules containing a modified starch matrix, which mainly includes 55-95wt% of modified starch and 5-45wt% of gelling agent as the matrix, the denatured Starch is a modified starch containing 1-2.5wt% of acetyl groups and 0-6.5wt% of hydroxypropoxyl groups. Although the hollow capsules prepared by the present invention can meet the pharmacopoeia standards, there are problems in the actual application process of pharmaceutical factories. Low rate, long disintegration time, short shelf life, unqualified capsule shape, etc.

Method used

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  • Composition for preparing hollow capsules of modified starch matrix and hollow capsules
  • Composition for preparing hollow capsules of modified starch matrix and hollow capsules
  • Composition for preparing hollow capsules of modified starch matrix and hollow capsules

Examples

Experimental program
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Effect test

Embodiment 1

[0030]From 95wt% modified corn starch (calculated as anhydrous, containing 2.2wt% acetyl group and 6wt% hydroxyoxy group and modified starch cross-linked by sodium trimetaphosphate, the cross-linking chemical bond is 2000 anhydroglucose units) , 3 wt % sorbitol, 1 wt % gellan gum, 1 wt % hypromellose prepared from the composition for preparing modified starch matrix hollow capsules.

[0031] The above-prepared composition for preparing the hollow capsules of modified starch matrix was mixed with water 6.5 times the weight of the composition and heated for gelatinization, the heating temperature was 70°C, and the heating time was 30 minutes. The hollow capsules were obtained by the conventional preparation process, and the disintegration time limit, the friability and the filling pass rate of the prepared hollow capsules were measured respectively, as shown in Table 1.

Embodiment 2

[0033] Modified starch composed of 80wt% modified tapioca starch (calculated as anhydrous, containing 2.5wt% acetyl group and 6.5wt% hydroxyloxy group and modified starch cross-linked by sodium trichlorophosphate, the cross-linking chemical bond is 1000 anhydroglucose unit), 10 wt % xylitol, 5 wt % pectin, 5 wt % glycerol prepared the composition of the hollow capsule for preparing modified starch matrix.

[0034] The composition for preparing the hollow capsules of modified starch matrix prepared above was mixed with water 3 times the weight of the composition and heated for gelatinization, the heating temperature was 95°C, and the heating time was 150 minutes. The hollow capsules were obtained by the conventional preparation process, and the disintegration time limit, the friability and the filling pass rate of the prepared hollow capsules were measured respectively, as shown in Table 1.

Embodiment 3

[0036] From 85wt% of modified tapioca starch (calculated as anhydrous, containing 1wt% of acetyl group and 2wt% of hydroxyoxyl and modified starch cross-linked by sodium trimetaphosphate, the cross-linking chemical bond is 350 anhydroglucose units), 8wt% of mannitol, 4wt% of carrageenan, 3wt% of chitosan and the composition for preparing modified starch matrix hollow capsules.

[0037] The composition for preparing the hollow capsules of modified starch matrix prepared above was mixed with water 4 times the weight of the composition and heated for gelatinization and gelatinization. The heating temperature was 80° C. and the heating time was 100 minutes. The hollow capsules were obtained by the conventional preparation process, and the disintegration time limit, the friability and the filling pass rate of the prepared hollow capsules were measured respectively, as shown in Table 1.

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Abstract

The invention discloses a composition for preparing empty capsules with modified starch matrixes. The composition comprises 80-95 wt% of modified starch, 3-15 wt% of fluidizers, 1-9 wt% of gelatinizers and 1-15 wt% of hygroscopic reinforcing agents. The modified starch comprises 0-2.5 wt% of acetyl and 0.5-6.5 wt% of hydroxypropoxy which are subjected to cross linking by sodium trimetaphosphate or phosphorus oxychloride. With the fluidizers, defects of thin shoulders, cone vertex and riffled ends of the capsules are avoided, swelling of the cross-linked starch is suppressed, consistency of gelatinous solution is reduced, and fluidity is improved. Therefore, the empty capsules with modified starch matrixes, having high flexibility, high fillibility, long preservation period and short disintegration time, can be prepared from the composition.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition for preparing a hollow capsule of a modified starch matrix and the hollow capsule. Background technique [0002] Empty capsules have been made from animal-derived gelatin for at least nearly 200 years. Because gelatin can mask the bad taste, smell or irritation to the stomach of many drugs, gelatin capsules are quickly popularized and applied in the production of various solid preparations. In the past 100 years, various capsules made of gelatin have been sold in the international pharmaceutical market for a long time. And at the end of the last century, the mad cow disease outbreak finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poison capsule" incident that broke out in my country undoubtedly aggravated the people's distrust of gelatin capsules. In addition, the gelatin capsule itself has many shortc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36
CPCA61K9/4816A61K47/36
Inventor 闫丰文袁国卿
Owner INST OF CHEM CHINESE ACAD OF SCI
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