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Medicine composition for treating brain glioma and application thereof

A glioma and composition technology, applied in the field of medicine, can solve the problems of large toxic and side effects of chemotherapeutic drugs, lack of chemotherapeutic drugs, etc., and achieve the effects of good treatment effect, reduction of tumor volume, and reduction of glioma tumor weight.

Inactive Publication Date: 2016-10-12
QINGDAO YUNTIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the lack of effective chemotherapeutic drugs in the existing glioma treatment process, and the defects of the existing chemotherapeutic drugs with large toxic and side effects, the present invention provides a safe and effective drug for the treatment of glioma, further increasing the number of glioma patients. The choice of clinical medication, the pharmaceutical composition uses elemene and pomalidomide as the active ingredients of the drug, which has a good therapeutic effect on glioma, less toxic and side effects, and has a good clinical application prospect

Method used

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  • Medicine composition for treating brain glioma and application thereof
  • Medicine composition for treating brain glioma and application thereof
  • Medicine composition for treating brain glioma and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 microemulsion concentrate

[0018] prescription

[0019]

[0020] Preparation process: Weigh the prescription amount of peppermint oil, caprylic ethyl oleate, 1,2-propylene glycol, and polyethylene glycol 3350, mix and stir evenly, then add elemene and pomalidomide to dissolve, or use ultrasonic treatment to dissolve Accelerate the dissolution to obtain a clear concentrated solution, which is the microemulsion concentrate of elemene and pomalidomide. The particle size was measured by a laser particle size analyzer, and the average particle size was 40nm. The above microemulsion concentrate can be further diluted for injection or oral administration.

Embodiment 2

[0021] Embodiment 2 microemulsion concentrate

[0022] prescription

[0023]

[0024] The preparation process is the same as in Example 1. The particle size was measured by a laser particle size analyzer, and the average particle size was 20nm. The above microemulsion concentrate can be further diluted for injection or oral administration.

Embodiment 3

[0025] Example 3 Microemulsion Concentrate

[0026] prescription

[0027]

[0028] The preparation process is the same as in Example 1. The particle size was measured by a laser particle size analyzer, and the average particle size was 33nm. The above microemulsion concentrate can be further diluted for injection or oral administration.

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Abstract

The invention belongs to the field of medicines, and particularly relates to a medicine composition and application thereof in preparation of medicines for treating brain glioma. The medicine composition is prepared from the following medicinal active ingredients: elemene and pomalidomide in an optimal proportion of (0.003-100):1, and a further optimal proportion of (0.01-50):1. Massive pharmacological experiments prove that elemene and pomalidomide have remarkable synthetic effects in the field of brain glioma treatment, and can be used for remarkably reducing the tumor size and weight and prolonging the surviving period. The medicine composition has the advantages of exact curative effect and small toxic and side effects when being used for treating brain glioma, and has good medical application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition for treating glioma and its use, in particular to a composition containing elemene and pomalidomide and its use in preparing medicine for treating glioma. Background technique [0002] Glioma is a tumor that occurs in the neuroectoderm, so it is also called neuroectodermal tumor or neuroepithelial tumor. Glioma is a highly recurrent brain tumor disease characterized by "three highs and one low" of morbidity, recurrence, high mortality and low cure rate. Its etiology is still unclear. Brain glioma (brain glioma) accounts for about 46% of intracranial tumors, with an incidence rate of 3 to 10 people per 100,000 people, and the peak age of onset is 30-40 years old, or 10-20 years old. Gliomas account for 1% to 3% of systemic malignant tumors, and the average survival period of surgery plus radiotherapy and chemotherapy is only 8 to 11 months. The growth character...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61K31/015A61P35/00
CPCA61K31/454A61K31/015A61K2300/00
Inventor 王传秀
Owner QINGDAO YUNTIAN BIOTECH
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