Medicine for treating hepatic adipose infiltration and hepatic fibrosis
A technology for liver fibrosis and fatty liver, applied in the field of medicine, can solve the problems of liver function damage, difficulty in exerting overall curative effect, and reduced metabolic rate, and achieve the effects of improving immunity, inhibiting liver fibrosis and overcoming slow dissolution.
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Embodiment 1
[0029] Example 1: Screening and optimization of drugs
[0030] Preventive and therapeutic effects of different drug combinations on rat fatty liver model induced by comprehensive factors
[0031] Experimental protocol: 180-200 grams of healthy male SD rats were selected, and the planned clinical dose was used to design the dose according to the ratio of human to rat body surface area. The crude drug doses of each drug formula were the same. Grouped as follows, each group has 10 rats , Drinking water freely, except for the normal control group with basic feed, the other groups are given high-fat feed. Modeling: High-fat feed formula: lard 20%, cholesterol 0.4%, bile salt 0.1%, basic feed 79.5%, feed according to body weight; meanwhile, gavage 30% alcohol every day for 20 days; subcutaneously every 5 days Inject 40% CCL4 oil solution (0.5ml / 100g for the first time, 0.3ml / 100g for the next 4 times) for 5 injections. After the model was successfully established, the drug was administ...
Embodiment 2
[0037] Example 2 Preparation of granules
[0038] Weigh 15g of Cordyceps sinensis, 12g of cattail yellow, 6g of tangerine peel, 5g of Yuliren, mix the cattail yellow, tangerine peel and Yuliren, pulverize, then add 200ml of 60% ethanol for reflux extraction, extract 3 times, 1 hour each time, filter and combine the filtrate. Concentrate under reduced pressure and dry to obtain powder 1.
[0039] After pulverizing the Cordyceps sinensis, ultra-fine pulverization is used to prepare powder 2 with a particle size range of 40-100um.
[0040] The powders 1 and 2 are mixed, edible ethanol with a concentration of 90% is sprayed, the soft material is sieved, granulated, and dried, and then the dry granules are packed into a bag.
Embodiment 3
[0041] Example 3 Preparation of tablets
[0042] Weigh 10g of Cordyceps sinensis, 9g of cattail yellow, 9g of tangerine peel, and 10g of Yuliren, mix the cattail yellow, tangerine peel and Yuliren, pulverize, add 250ml of 80% ethanol for reflux extraction, extract twice, 1.5 hours each time, filter and combine the filtrate. Concentrate under reduced pressure and dry to obtain powder 1.
[0043] After pulverizing the Cordyceps sinensis, ultra-fine pulverization is used to prepare powder 2 with a particle size range of 40-100um.
[0044] The powders 1 and 2 are mixed, then mixed with starch, sprayed with 90% edible ethanol, the soft material is sieved, granulated, dried, magnesium stearate and 1.5% HPMC solution are added, mixed and compressed into tablets.
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