Medicine for treating hepatic adipose infiltration and hepatic fibrosis

A technology for liver fibrosis and fatty liver, applied in the field of medicine, can solve the problems of liver function damage, difficulty in exerting overall curative effect, and reduced metabolic rate, and achieve the effects of improving immunity, inhibiting liver fibrosis and overcoming slow dissolution.

Inactive Publication Date: 2016-10-12
青海珠峰冬虫夏草工程技术研究有限公司
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Obesity and overweight, too much fat accumulation in the body can lead to fatty liver, and too much fat in the liver will increase the burden on the liver, reduce the metabolic rate, and aggravate the degree of fatty liver
Western medicine often uses lipid-lowering drugs alone to deal with it, and the pathology of fatty liver is not only a problem of lipid-lowering, but also includes damage to liver function after fat infiltration in the liver, and simple use of Western medicine to lower lipids often produces side effects and damages liver function .Traditional Chinese medicine has the characteristics of multi-component, multi-target, and multi-pathway. However, most of the current Chinese medicines are mainly for lipid-lowering, and the problem of preventing liver fibrosis is not taken into account at the same time. It is difficult to exert the overall curative effect, and the therapeutic effect is limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine for treating hepatic adipose infiltration and hepatic fibrosis
  • Medicine for treating hepatic adipose infiltration and hepatic fibrosis
  • Medicine for treating hepatic adipose infiltration and hepatic fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Screening and optimization of drugs

[0030] Preventive and therapeutic effects of different drug combinations on rat fatty liver model induced by comprehensive factors

[0031] Experimental protocol: 180-200 grams of healthy male SD rats were selected, and the planned clinical dose was used to design the dose according to the ratio of human to rat body surface area. The crude drug doses of each drug formula were the same. Grouped as follows, each group has 10 rats , Drinking water freely, except for the normal control group with basic feed, the other groups are given high-fat feed. Modeling: High-fat feed formula: lard 20%, cholesterol 0.4%, bile salt 0.1%, basic feed 79.5%, feed according to body weight; meanwhile, gavage 30% alcohol every day for 20 days; subcutaneously every 5 days Inject 40% CCL4 oil solution (0.5ml / 100g for the first time, 0.3ml / 100g for the next 4 times) for 5 injections. After the model was successfully established, the drug was administ...

Embodiment 2

[0037] Example 2 Preparation of granules

[0038] Weigh 15g of Cordyceps sinensis, 12g of cattail yellow, 6g of tangerine peel, 5g of Yuliren, mix the cattail yellow, tangerine peel and Yuliren, pulverize, then add 200ml of 60% ethanol for reflux extraction, extract 3 times, 1 hour each time, filter and combine the filtrate. Concentrate under reduced pressure and dry to obtain powder 1.

[0039] After pulverizing the Cordyceps sinensis, ultra-fine pulverization is used to prepare powder 2 with a particle size range of 40-100um.

[0040] The powders 1 and 2 are mixed, edible ethanol with a concentration of 90% is sprayed, the soft material is sieved, granulated, and dried, and then the dry granules are packed into a bag.

Embodiment 3

[0041] Example 3 Preparation of tablets

[0042] Weigh 10g of Cordyceps sinensis, 9g of cattail yellow, 9g of tangerine peel, and 10g of Yuliren, mix the cattail yellow, tangerine peel and Yuliren, pulverize, add 250ml of 80% ethanol for reflux extraction, extract twice, 1.5 hours each time, filter and combine the filtrate. Concentrate under reduced pressure and dry to obtain powder 1.

[0043] After pulverizing the Cordyceps sinensis, ultra-fine pulverization is used to prepare powder 2 with a particle size range of 40-100um.

[0044] The powders 1 and 2 are mixed, then mixed with starch, sprayed with 90% edible ethanol, the soft material is sieved, granulated, dried, magnesium stearate and 1.5% HPMC solution are added, mixed and compressed into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a medicine for treating hepatic adipose infiltration and hepatic fibrosis. The medicine for treating the hepatic adipose infiltration and the hepatic fibrosis is prepared from the following bulk drugs: cordyceps sinensis, typha angustifolia, pericarpium citri reticulatae and semen pruni. The medicine provided by the invention has the effects that the contents of total cholesterol and TG (Triglyceride) in a liver can be quite obviously decreased; the rise, which is caused by a composite factor, of the vitality of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in a serum can be quite obviously decreased; further, the immunity can be improved; the hepatic fibroplasias can be obviously suppressed. The medicine for treating the hepatic adipose infiltration and the hepatic fibrosis is mainly used for invigorating spleen and kidney, eliminating blood stasis and removing dampness through diuresis; the effectiveness of treating the hepatic adipose infiltration is realized from the nature of a disease.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating fatty liver and liver fibrosis. Background technique [0002] With the improvement of living standards and the influence of various unhealthy lifestyles, the incidence of fatty liver is on the rise. People of different ages and different genders can develop fatty liver. Like hypertension and diabetes, fatty liver has become one of the common chronic diseases of contemporary people, becoming the second largest liver disease after viral hepatitis. It can progress to liver fibrosis, cirrhosis, and even liver cancer, and then develop into cirrhosis of the liver. The proportions of liver cancer and liver cancer are 5%-10% and 1%-2%, respectively. A large number of studies have confirmed the relationship between age, gender, obesity and metabolic abnormalities and the onset of fatty liver. Such a large number of patients have caused fatty liver to attract attentio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61K9/16A61K9/20A61K9/48A61P1/16
CPCA61K36/068A61K9/1605A61K9/1652A61K9/2004A61K9/2054A61K31/715A61K36/736A61K36/752A61K36/88A61K2236/331A61K2236/333A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 王辉王玉花张海峰夏敏贞韩贵香刘芙蓉巩俐英
Owner 青海珠峰冬虫夏草工程技术研究有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap