A kind of 4-oxo-2-thiothiazolidinyl derivative and its preparation method and application

A thiothiazolidine and derivative technology, applied in the field of biomedicine, can solve the problems of reduced activity of promoting microtubule assembly, impact on dynamic behavior of microtubules, cell death, etc., to prevent tubulin depolymerization and treat Alzheimer's disease. Hymer's disease, the effect of protecting nerve cells
CN106008494BInactive Publication Date: 2019-08-27GUANGDONG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG UNIV OF TECH
Publication Date
2019-08-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Belonging to the technical field of biomedicine, the invention discloses a 4-oxo-2-thiothiazolidine containing derivative, a preparation method and application thereof. The derivative involved in the invention contains a compound shown as general formula I, wherein n is an integer 1 or 2; R1 is an ester group or amide or acid group; R2 is one of hydrogen, isopropyl or methoxy. Most compounds of the type have an inhibiting effect on tau protein polymerization, also has a stabilizing effect on tubulin, and can be effectively used for treatment of Alzheimer's disease.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and specifically relates to a 4-oxo-2-thiothiazolidinyl derivative and its preparation method and application. Background technique

[0002] Alzheimer's disease (Alzheimer's disease, AD) is dementia caused by chronic progressive central nervous system degenerative disease, is the most common cause of dementia and the most common senile dementia. AD is characterized by neuropsychiatric symptoms such as progressive memory impairment, cognitive impairment, personality changes, and language impairment. Often onset in old age or early old age, more slowly onset, gradually progressing, with dementia as the main manifestation. The cause of disease is unknown so far, and there is no specific medicine or method for curing it. However, the number of patients is increasing year by year around the world. There are currently 5 million patients in China, and it will reach 10 million by 2020. By 2050, th...

Claims

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