Silica-coated quantum dot multifunctional nanocomposite material and preparation method thereof

Abstract

The invention provides a multifunctional nano composite material comprising silica-coated quantum dots. The nano composite material has a core-shell structure, wherein the core is formed by the quantum dots, and the shell is formed by gadolinium-doped silica. The multifunctional nano composite material comprising the silica-coated quantum dots has a near infrared emission function, is high in fluorescence intensity, high in quantum efficiency, good in biocompatibility, deep in tissue penetration, low in background interference and free from or low in toxicity, and has a fluorescent function and an MRI development function, thus having very wide application prospect in the technical field of bioluminescence imaging.

Description

technical field

[0001] The invention belongs to the field of multifunctional nanocomposite materials, in particular to a multifunctional silicon dioxide-coated quantum dot nanocomposite material with both fluorescence and MRI imaging and a preparation method thereof. Background technique

[0002] Bioluminescent imaging technology can perform real-time and visualized nondestructive detection of biomolecules, cells, tissues and organs on a three-dimensional scale, and has become an important tool in the current biomedical field. It has developed rapidly in recent years, especially in tumor diagnosis, biological Molecular detection and many other fields have a very wide range of applications. Because the organism itself lacks signals for effective analysis, it is usually necessary to analyze biological samples with the help of foreign labeled materials.

[0003] Compared with biological imaging in the visible light region, the near-infrared light region not only has less scatt...

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