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Silica-coated quantum dot multifunctional nanocomposite material and preparation method thereof

A nano-composite material, silica technology, applied in chemical instruments and methods, luminescent materials, preparations for in vivo tests, etc. The effect of high quantum efficiency, avoiding large drops, and low background interference

Active Publication Date: 2018-05-01
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to its short residence time in the human body, it has serious side effects of liver and kidney toxicity, which seriously affects its clinical application.

Method used

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  • Silica-coated quantum dot multifunctional nanocomposite material and preparation method thereof
  • Silica-coated quantum dot multifunctional nanocomposite material and preparation method thereof
  • Silica-coated quantum dot multifunctional nanocomposite material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] The multifunctional nanocomposite material prepared in this example is Gd, Cu:CdS / ZnS@SiO 2 , wherein the near-infrared quantum dots selected are Cu:CdS / ZnS, the gadolinium source is gadopentetate meglumine (Gd-DTPA), and the specific preparation steps are:

[0027] Step 1: Dissolving Cu:CdS / ZnS quantum dots in 10mL cyclohexane to form a Cu:CdS / ZnS quantum dot solution with a quantum dot concentration of 1mM;

[0028] Step 2: In the quantum dot solution obtained in step 1, add 0.1 mL tetraethylorthosilicate (TEOS) under magnetic stirring conditions, and add 1 mL polyoxyethylene (5) nonylphenyl ether ( NP5), after 30 min, add 0.05 mL catalyst methylamine (MA) and a certain amount of gadopentetate meglumine injection (Gd-DTPA, Gd / Cd=0.5) dropwise;

[0029]Step 3: After reacting for 24 hours under magnetic stirring conditions, drop acetone to terminate the reaction; centrifuge the reaction solution to obtain Gd,Cu:CdS / ZnS@SiO 2 Nanoparticles; Gd,Cu:CdS / ZnS@SiO 2 The nan...

Embodiment 2

[0035] The multifunctional nanocomposite material prepared in this embodiment is Gd, CuInS 2 / ZnS@SiO 2 , where the near-infrared quantum dots selected are CuInS 2 / ZnS, the gadolinium source is gadopentetate meglumine (Gd-DTPA), and the specific preparation steps are:

[0036] Step 1: Add CuInS 2 / ZnS quantum dots were dissolved in 10mL cyclohexane to form CuInS with a quantum dot concentration of 1mM 2 / ZnS quantum dot solution;

[0037] Step 2: In the quantum dot solution obtained in step 1, add 0.1 mL tetraethylorthosilicate (TEOS) under magnetic stirring conditions, and add 1 mL polyoxyethylene (5) nonylphenyl ether ( NP5), after 30 minutes, add 0.05mL catalyst dimethylamine (DMA) and a certain amount of gadopentetate meglumine injection (Gd-DTPA, Gd / Cd=0.5) dropwise;

[0038] Step 3: After reacting for 24 hours under magnetic stirring conditions, drop acetone to terminate the reaction; centrifuge the reaction solution to obtain Gd, CuInS 2 / ZnS@SiO 2 Nanoparticles...

Embodiment 3

[0040] The multifunctional nanocomposite material prepared in this embodiment is Gd, CuInSe 2 / ZnS@SiO 2 , where the near-infrared quantum dots selected are CuInSe 2 / ZnS, the gadolinium source is gadopentetate meglumine (Gd-DTPA), and the specific preparation steps are:

[0041] Step 1: Add CuInSe 2 / ZnS quantum dots were dissolved in 10mL cyclohexane to form CuInSe with a quantum dot concentration of 1mM 2 / ZnS quantum dot solution;

[0042] Step 2: In the quantum dot solution obtained in step 1, add 0.1 mL tetraethylorthosilicate (TEOS) under magnetic stirring conditions, add 1 mL polyoxyethylene (9) nonylphenyl ether ( NP9), after 30 min, add 0.05 mL catalyst methylamine (MA) and a certain amount of gadopentetate meglumine injection (Gd-DTPA, Gd / Cd=0.3) dropwise;

[0043] Step 3: After reacting for 24 hours under magnetic stirring conditions, drop acetone to terminate the reaction; centrifuge the reaction solution to obtain Gd, CuInSe 2 / ZnS@SiO 2 Nanoparticles; Gd,...

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Abstract

The invention provides a multifunctional nano composite material comprising silica-coated quantum dots. The nano composite material has a core-shell structure, wherein the core is formed by the quantum dots, and the shell is formed by gadolinium-doped silica. The multifunctional nano composite material comprising the silica-coated quantum dots has a near infrared emission function, is high in fluorescence intensity, high in quantum efficiency, good in biocompatibility, deep in tissue penetration, low in background interference and free from or low in toxicity, and has a fluorescent function and an MRI development function, thus having very wide application prospect in the technical field of bioluminescence imaging.

Description

technical field [0001] The invention belongs to the field of multifunctional nanocomposite materials, in particular to a multifunctional silicon dioxide-coated quantum dot nanocomposite material with both fluorescence and MRI imaging and a preparation method thereof. Background technique [0002] Bioluminescent imaging technology can perform real-time and visualized nondestructive detection of biomolecules, cells, tissues and organs on a three-dimensional scale, and has become an important tool in the current biomedical field. It has developed rapidly in recent years, especially in tumor diagnosis, biological Molecular detection and many other fields have a very wide range of applications. Because the organism itself lacks signals for effective analysis, it is usually necessary to analyze biological samples with the help of foreign labeled materials. [0003] Compared with biological imaging in the visible light region, the near-infrared light region not only has less scatt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/88C09K11/84A61K49/00A61K49/10
CPCA61K49/0019A61K49/005A61K49/105C09K11/025C09K11/7702C09K11/886
Inventor 李万万武卫杰赵冰夏
Owner SHANGHAI JIAOTONG UNIV
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