Preparation method of a matrine transdermal agent

A ginseng transdermal agent and matrine technology are applied in the field of preparation of matrine transdermal agents, and can solve the problems of inconvenient clinical administration of liquid preparations, limited utilization, etc. quick results

Inactive Publication Date: 2016-10-19
TIANJIN PHARMACN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is used as a topical preparation, it is often limited du

Method used

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Effect test

Embodiment 1

[0028] A matrine transdermal agent mainly contains matrine, and the encapsulation rate is 86.79±1.68%.

[0029] The preparation method of above-mentioned a kind of matrine transdermal agent, concrete preparation steps are as follows:

[0030] (1) Superfinely pulverize matrine and pass through a 200-mesh sieve;

[0031] (2) taking matrine 25g as raw material;

[0032] (3) Add matrine to 1L of absolute ethanol, and stir magnetically for 6 hours at room temperature in a closed explosion-proof environment;

[0033] (4) Put the solution obtained in step (3) into distilled water with V / V of 16:1, stir for 30min, and set aside;

[0034] (5) Dissolve 1g of chitosan in 32mL of 1% glacial acetic acid solution, stir and dissolve to obtain chitosan glacial acetic acid solution, wherein the stirring temperature is 45-55°C, and the heating method is steam heating;

[0035] (6) Dissolving 32mL of Chinese medicinal extract A in step (5) oligochitosaccharide glacial acetic acid solution to ...

Embodiment 2

[0044] A matrine transdermal agent mainly contains matrine, and the encapsulation rate is 84.89±1.79%.

[0045] The preparation method of above-mentioned a kind of matrine transdermal agent, concrete preparation steps are as follows:

[0046] (1) Superfinely pulverize matrine and pass through a 300-mesh sieve;

[0047] (2) taking matrine 30g as raw material;

[0048] (3) Add matrine to 1L of absolute ethanol, and stir magnetically for 6 hours at room temperature in a closed explosion-proof environment;

[0049] (4) Put the solution obtained in step (3) into distilled water with V / V of 16:1, stir for 30min, and set aside;

[0050] (5) Dissolve 7.5 g of chitosan in 160 mL of 2% glacial acetic acid, stir and dissolve to obtain chitosan glacial acetic acid solution, the stirring temperature is 45, and the heating method is steam heating.

[0051] (6) Dissolve 160 mL of Chinese medicine extract A in step (5) chitooligosaccharide glacial acetic acid solution to obtain mixed solut...

Embodiment 3

[0060] A matrine transdermal agent mainly contains matrine, and the encapsulation rate is 81.89±1.33%.

[0061] The preparation method of above-mentioned a kind of matrine transdermal agent, concrete preparation steps are as follows:

[0062] (1) Superfinely pulverize matrine and pass through a 100-mesh sieve;

[0063] (2) taking matrine 28g as raw material;

[0064] (3) Add matrine to 1L of absolute ethanol, and stir magnetically for 6 hours at room temperature in a closed explosion-proof environment;

[0065] (4) Put the solution obtained in step (3) into distilled water with V / V of 16:1, stir for 30min, and set aside;

[0066] (5) Dissolve 1.8g of chitosan in 32mL of 3% glacial acetic acid, stir and dissolve to obtain a chitosan glacial acetic acid solution, the stirring temperature is 55°C, and the heating method is steam heating.

[0067] (6) Dissolve 64mL of Chinese medicine extract A in step (5) chitooligosaccharide glacial acetic acid solution to obtain mixed soluti...

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Abstract

The invention relates to a preparation method of a matrine transdermal agent. The method comprises the following steps: (1) successively dissolving matrine in anhydrous ethanol and distilled water; (2) heating to prepare a chitosan glacial acetic acid solution; (3) mixing a traditional Chinese herbal extract with the chitosan glacial acetic acid solution; (4) adding the mixture into an emulsification system for emulsification; (5) conducting a cross-linking reaction on the emulsion products; and (6) treating the crosslinking products by washing, precipitation, centrifugation and drying to obtain a transdermal medical membrane loaded with traditional Chinese herbal extract. The preparation method is simple, and suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to a preparation method of a transdermal agent, in particular to a preparation method of a matrine transdermal agent. Background technique [0002] Matrine is the main active alkaloid in the traditional Chinese medicine Sophora flavescens. Modern medical research shows that matrine has the characteristics of fast absorption, fast metabolism, and short half-life (2.8 hours), so it is administered orally or intramuscularly. When, frequent administration is required to maintain the effective blood concentration of the drug, so it is necessary to develop its long-acting preparation. [0003] The transdermal agent is a space network water-filled cross-linked structure formed by mixing hydrophilic polymer materials, moisturizers, cross-linking agents, etc. with drugs. It has the advantages of large amount, favorable drug release and transdermal absorption. Etosomes have the characteristics of high drug encapsulation efficiency, good s...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4375A61K47/36A61P1/16A61P31/14A61P31/20A61P35/00A61P9/14
Inventor 田东奎何磊
Owner TIANJIN PHARMACN MEDICAL TECH
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