A high-density near-infrared spectroscopy brain functional imaging method with multiple coupling of space-time and frequency
A technology of near-infrared spectroscopy and imaging methods, which is applied in the field of high-density near-infrared spectroscopy brain function imaging and parallel detection data, can solve problems such as signal-to-noise ratio reduction, reduce crosstalk, improve parallel detection efficiency, and improve time resolution The effect of rate and spatial resolution
Active Publication Date: 2017-11-21
DANYANG HUICHUANG MEDICAL EQUIP CO LTD
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However, the time resolution of this method can only be improved to a limited extent, and it includes signal crosstalk between detection channels, which reduces the signal-to-noise ratio
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[0027] The high-density near-infrared spectrum brain function imaging method proposed by the present invention with multiple coupling of space-time and frequency will be further described below in conjunction with the accompanying drawings.
[0028] In this embodiment, the light source detector arrangement of 192 light sources is taken as an example. There are three light sources with different wavelengths (785nm, 808nm, and 850nm) overlapping at one light source incident point, so there are 64 light source groups distributed in 64 different light source incident points. point, such as Figure 1A and Figure 1B as shown, Figure 1B The hollow squares are detectors, the solid black circles represent light sources 1 to 64, and the lines connecting the light sources and detectors represent detection channels. Figure 1A is a schematic diagram of light source probes and detectors placed on the head, Figure 1B Schematic diagram of the layout of the light source detector. Usually...
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The invention discloses a space-time-frequency multi-coupling high-density functional near-infrared spectroscopy brain function imaging method, and relates to the technical field of medical imaging. The imaging method comprises steps of detection channel division, light source time and space fragmentation, intelligent allocation of light source lightening time, power and frequency and detector coding. The imaging method disclosed by the invention can relieve cross-talk among detection channels and can improve time resolution, spatial resolution and a signal-to-noise ratio; by conducting the intelligent allocation of light source lightening time, power and frequency, the method is beneficial for improving spatial resolution and signal-to-noise ratio of a system; and by coding a detector, a parallel detection frequency is improved; therefore, the method has incomparable application advantages in the high-density fNIRS system.
Description
technical field [0001] The invention relates to the technical field of medical imaging, in particular to a high-density near-infrared spectral brain function imaging method with multiple coupling of space-time and frequency, and is a method for realizing parallel detection data. Background technique [0002] In recent years, near-infrared spectroscopy (Functional near-infrared spectroscopy, fNIRS) has developed into a new generation of imaging modality indispensable in brain function research and clinical diagnosis. fNIRS uses near-infrared light with a wavelength of 650-1000nm to detect changes in optical absorption characteristics caused by brain metabolism, thereby calculating deoxygenated hemoglobin (HbR), oxygen-carrying hemoglobin (HbO 2 ) relative change in concentration. Compared with traditional brain functional imaging methods, such as EEG and functional magnetic resonance imaging, fNIRS has the advantages of high cost performance, high temporal resolution, modera...
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IPC IPC(8): A61B5/00A61B5/026
CPCA61B5/0042A61B5/0075A61B5/0261A61B5/72A61B5/7203
Inventor 汪恭正
Owner DANYANG HUICHUANG MEDICAL EQUIP CO LTD