Ropivacaine mesylate freeze-dried powder injection for injection and preparation method thereof
A technology of ropivacaine mesylate and freeze-dried powder injection, which is applied in the field of preparation of ropivacaine mesylate freeze-dried powder injection for injection, and can solve the problem of unsuitability for large-scale industrial production, high cost input and complicated operation and other problems, to achieve the effect of good resolubility and clarity, high yield and good resolubility
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0043] A ropivacaine mesylate freeze-dried powder for injection, comprising the following components:
[0044] Ropivacaine mesylate 89.4g;
[0045] Mannitol 50g;
[0046] Add 5% ethanol aqueous solution to 1000mL;
[0047] Its preparation method is as follows:
[0048](1) Accurately weigh the ropivacaine mesylate of the prescription amount, add mass percentage concentration and be 5% ethanol solution, stir and dissolve; add the mannitol of recipe amount again, continue to stir and dissolve; Obtain mixed solution, wherein stir and dissolve When, the speed of stirring is 80 rpm;
[0049] (2) Regulate the pH value of the mixed solution obtained in step (1) to 4.0-6.0 with 0.1mol / L NaOH solution, and add an aqueous ethanol solution with a mass percentage concentration of 5% to the prescription amount;
[0050] (3) Add activated carbon for needles to the mixed solution obtained in step (2), the dosage of activated carbon for needles is 0.1% g / mL; after stirring and absorbing fo...
Embodiment 2
[0053] A ropivacaine mesylate freeze-dried powder for injection is characterized in that the freeze-dried powder includes the following components:
[0054] Ropivacaine mesylate 119.2g;
[0055] Mannitol 40g;
[0056] Add 10% ethanol aqueous solution to 1000mL;
[0057] Its preparation method is as follows:
[0058] (1) Accurately weigh the ropivacaine mesylate of the prescription amount, add the mass percent concentration and be 10% ethanol solution, stir and dissolve; add the mannitol of the recipe amount again, continue to stir and dissolve; obtain the mixed solution, the speed of stirring 120 rpm;
[0059] (2)) Use 0.1mol / L NaOH solution to adjust the pH value of the mixed solution obtained in step (1) to 4.0-6.0, and add an aqueous ethanol solution with a mass percentage concentration of 10% to the prescription amount;
[0060] (3) Add activated carbon for needles to the mixed solution obtained in step (2), the dosage of activated carbon for needles is 0.1% g / mL; afte...
Embodiment 3
[0063] The sample obtained in Example 1 of the present application is detected, and the obtained results are as follows:
[0064]
[0065] As can be seen from the above table, the ropivacaine mesylate freeze-dried powder injection prepared by the present application fully complies with the relevant regulations of the Pharmacopoeia.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com