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A self-heating transdermal drug delivery system having a heat-sensitive substrate and a preparing method thereof

A drug delivery system and self-heating technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and sheet delivery, etc., can solve the problems of accelerating transdermal effect, increasing drug dissolution, etc. The effect of improving the transdermal absorption rate and simple operation

Inactive Publication Date: 2016-10-26
邬春艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of ordinary transdermal drug delivery parts cannot use the heating device to increase the drug dissolution rate to accelerate the transdermal effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In this example, the active components of indomethacin are transdermally administered. Because oral administration of indomethacin can stimulate the stomach and intestinal tract, and the drug is absorbed slowly after oral administration, the heat-sensitive substrate is used Skin administration directly to the affected area has a rapid onset of effect.

[0020] (1) Mix indomethacin into 120ml of 2% ethanol solution, prepare 10ml of azone, 20ml of propylene glycol, 8ml of peppermint oil, and 2ml of Tween 80, and stir and mix the drug solution and the transdermal administration solution .

[0021] (2) Add 140ml of PEG400 into the above mixture, stir, heat to 60°C and keep it warm.

[0022] (3) Slowly add 20g of PEG10000 and 2g of PVA into the above solution and stir until completely dissolved, then stop heating, continue to stir and cool down to room temperature naturally to prepare a milky white translucent medicinal ointment.

[0023] (4) Take 5ml of the drug ointment ...

Embodiment 2

[0026] In this example, the active component of ribavirin is administered transdermally. Because the absorption of ribavirin is slow when taken orally, the heat-sensitive matrix is ​​used to directly deliver the drug to the affected area through the heat-sensitive matrix and the effect is rapid.

[0027] (1) Make ribavirin 1.5% ethanol solution 150ml, prepare azone 10ml, propylene glycol 20ml, peppermint oil 8ml, Tween 80 2ml mixed solution, mix the drug solution and transdermal administration solution evenly .

[0028] (2) Add 140ml of PEG400 into the above mixture, stir, heat to 40°C and keep it warm.

[0029] (3) Slowly add 20g of PEG10000 and 2g of PVA into the above solution and stir until completely dissolved, then stop heating, continue to stir and cool down to room temperature naturally to prepare a milky white translucent medicinal ointment.

[0030] (4) Take 5ml of the drug ointment and apply it on the non-woven fabric with a backing film, then stick the drug-loaded...

Embodiment 3

[0033] The present embodiment treats the active components of traditional Chinese medicine Herba Asarum, Lianzixin, Clematis, Curcuma, Rhizoma Rhizoma Corydalis, Radix Rhizoma Rhizoma Radix, Radix Sinensis, Moschus, Radish Seed, Frankincense, Psoraleae, and Phoenix Garment for the treatment of periarthritis of shoulder. Transdermal administration is implemented, and the heat-sensitive matrix is ​​used to directly deliver the effect to the affected area through the heat-sensitive matrix.

[0034] (1) 15g asarum, 11g lotus seed heart, 9g clematis, 8g curcuma, 15g corydalis, 15g raw rhubarb, 10g sheath, 5g musk, 10g radish seed, 9g frankincense, 12g psoralen, 8g phoenix coat Add eight times the weight of water and decoct three times to combine the medicinal solution. After the medicinal solution is concentrated, take 130ml of the medicinal solution, prepare a mixed solution of 10ml of azone, 20ml of propylene glycol, 8ml of peppermint oil, and 2ml of Tween 80. Solution The two li...

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PUM

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Abstract

The invention discloses a thermosensitive matrix self-heating transdermal drug delivery system, which comprises a drug active part, a transdermal drug delivery part and a drug-loaded matrix part. The transdermal drug delivery part includes azone, propylene glycol, peppermint, and Tween. The drug base part includes polyvinyl alcohol (PVA) and polyethylene glycols of different molecular weights. The drug-carrying matrix of the present invention cooperates with the heating part, so that the drug can rapidly dissolve out of the matrix material when the temperature rises, and quickly enter the skin under the action of the transdermal agent, which can greatly improve the transdermal efficiency.

Description

technical field [0001] The invention relates to a transdermal drug delivery system, in particular to a heat-sensitive substrate self-heating transdermal drug delivery system. Background technique [0002] Transdermal drug delivery system (TDDS), also known as transdermal therapeutic system (TDS), refers to the control system in which drugs are released from specially designed devices, absorbed through the complete skin, and enter the blood system of the whole body. release dosage form. The transdermal drug delivery system (TDDS) preparation avoids the liver first-pass effect and gastrointestinal inactivation that may occur during oral administration. The absorption of drugs is not affected by gastrointestinal factors. The individual differences are small, and the drugs can continue to diffuse into the body for a long time. Blood circulation, prolonging the effective time of action, constant blood drug concentration, avoiding the peak and valley phenomenon of blood drug conc...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/10A61K47/22A61K47/46A61K47/26
CPCA61K9/7053A61K47/10A61K47/22A61K47/26A61K47/46
Inventor 邬春艳王荻
Owner 邬春艳
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