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Itch-dispelling and pain-relieving pollen spray and preparation method thereof

A production method and spray technology, which are applied in non-central analgesics, aerosol delivery, anti-inflammatory agents, etc., can solve the problems that ethanol is easy to volatilize, difficult to detect, and affect the curative effect of drugs, so as to achieve good clinical curative effect, Dissolution-promoting and efficacy-increasing effects

Inactive Publication Date: 2016-11-09
GUIZHOU HONGKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the tincture contains a large amount of ethanol, it is not suitable for patients whose skin is sensitive to ethanol, and the ethanol is easy to volatilize during the storage of the tincture, which will affect the curative effect of the drug
In addition, the applicant also found that the active ingredients of frankincense, especially the content of 11-carbonyl-β-acetyl boswellic acid, were not easy to detect in pollen antipruritic and pain-relief preparations prepared by the existing extraction process.
The clinical curative effect of making pollen antipruritic and pain relieving preparation is not ideal enough

Method used

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  • Itch-dispelling and pain-relieving pollen spray and preparation method thereof
  • Itch-dispelling and pain-relieving pollen spray and preparation method thereof
  • Itch-dispelling and pain-relieving pollen spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Prescription: 45g of trichosanthes, 45g of Angelica dahurica, 34g of Artemisia annua, 4g of borneol, 5g of camphor, 20g of vinegar-made frankincense, 20g of vinegar-made myrrh, 10ml of peppermint oil, 5ml of eucalyptus oil, 35g of glycerin, 0.4g of sodium bisulfite, B 0.4 g of disodium diamine tetraacetate and 40 g of distilled water.

[0099] Process:

[0100] (1) Take trichosanthum pollen, Artemisia japonica, vinegar-made myrrh, and Angelica dahurica into coarse particles, mix well, add 80% ethanol to infiltrate for 24 hours, and then use 80% ethanol to impregnate three times, the first time for 3 hours; second, Three times for 2 hours each, combine the soaking solutions for 3 times, filter to obtain a mixed filtrate, and set aside; then take frankincense made of vinegar, extract volatile oil by steam distillation, set aside; add 4 times the amount of 80% ethanol solution to the dregs, and extract 2 times, each 1h, filter, combine the filtrates, reclaim the ethanol t...

Embodiment 2

[0106] Prescription: 60g of trichosanthum powder, 60g of Angelica dahurica, 50g of Artemisia annua, 8g of borneol, 8g of camphor, 30g of vinegar-made frankincense, 30g of vinegar-made myrrh, 30ml of peppermint oil, 8ml of eucalyptus oil, 40ml of glycerin, 0.8g of sodium bisulfite, B 0.8 g of disodium diamine tetraacetate and 50 g of distilled water.

[0107] Process:

[0108] (1) Take trichosanthum pollen, Artemisia japonica, vinegar-made myrrh, and Angelica dahurica into coarse particles, mix well, add 85% ethanol to infiltrate for 28 hours, and then use 85% ethanol to impregnate three times, the first time at 4 o'clock; the second, Three times for 3 hours each, combine the soaking solutions for 3 times, and filter to obtain the mixed filtrate for later use; then take vinegar to make frankincense, extract the volatile oil by steam distillation, and then add 5 times the amount of 85% ethanol solution to the dregs, and reflux to extract 3 times, 1.5h each time, filter, combine...

Embodiment 3

[0113] Prescription: 30g of trichosanthum powder, 30g of Angelica dahurica, 20g of Artemisia annua, 1g of borneol, 1g of camphor, 10g of vinegar-made frankincense, 10g of vinegar-made myrrh, 5ml of peppermint oil, 1ml of eucalyptus oil, 30ml of glycerin, 0.1g of sodium bisulfite, B 0.1 g of disodium diamine tetraacetate and 30 g of distilled water.

[0114] Process:

[0115] (1) Take trichosanthum pollen, Artemisia japonica, vinegar-made myrrh, and Angelica dahurica into coarse particles, mix well, add 75% ethanol to infiltrate for 20 hours, and then use 75% ethanol to impregnate three times, the first time 2 hours; the second, Three times for 1 hour each, combine the soaking solutions for 3 times, and filter to obtain the mixed filtrate for later use; then take vinegar to make frankincense, distill it with water to extract volatile oil, and then add 3-5 times the amount of 75-85% ethanol to the dregs Solution, reflux extraction for 0.5h, filter, combine the filtrates, recove...

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Abstract

The invention discloses an itch-dispelling and pain-relieving pollen spray and a producing method thereof. The externally-used spray is mainly prepared from radix trichosanthis, angelica dahurica, short-pedicel aconite roots, borneol, camphor, vinegar processed frankincense, vinegar processed myrrh, peppermint oil, eucalyptus oil and auxiliary materials. The spray is prepared according to the properties of medicines in an itch-dispelling and pain-relieving pollen composition and the effects played by the medicines in the composition, used substrates are screened, the usage amount of the substrates is optimized, so that the medicinal effect is remarkably improved, and the itch-dispelling and pain-relieving pollen spray is suitable for various patients. In addition, specific preparation processes and parameters are improved, the substrates and the preparation process are combined, and dissolution of effective ingredients in the frankincense, especially dissolution of the effective ingredient 11-carbonyl-beta-acetyl masticinic acid (AKBA) in the frankincense is promoted, so that the itch-dispelling and pain-relieving pollen spray is more refined, the medicinal effect is more remarkable, and a clinic treating effect is good.

Description

technical field [0001] The invention relates to a pollen spray for relieving itching and relieving pain and a preparation method thereof, belonging to the field of pharmaceutical technology. technical background [0002] Bruises seem to be a common occurrence for some people in daily life. Traditional Chinese medicine has a history of thousands of years in treating bruises. The ancient name "bruises" is a summary of all injuries. Most of them are caused by external forces or incorrect posture. caused by excessive force. In traditional Chinese medicine, injuries to muscles and bones, blood stasis, swelling and pain, disharmony of Qi and blood, blockage of meridians and even damage to organs caused by external forces acting on the human body are collectively referred to as bruises. Its main pathology is congestion and stagnation, blood stagnation and air resistance, so pain and swelling are the main manifestations. Treatment is mostly based on promoting blood circulation and...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/12A61K47/18A61K47/04A61P29/00A61P17/04A61K31/125A61K31/045
CPCA61K36/714A61K9/12A61K31/045A61K31/125A61K36/232A61K36/324A61K36/328A61K36/428A61K36/534A61K36/61A61K47/02A61K47/183A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 龙凤荣李珂王瑶孙敏
Owner GUIZHOU HONGKANG PHARMA
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