Safe and stable medicine rubber plug material and preparing method thereof

Abstract

The invention discloses a safe and stable medicine rubber plug material and a preparing method thereof. The safe and stable medicine rubber plug material is prepared from, by mass, 42-56 parts of butyl rubber, 14-20 parts of silicone rubber, 6-11 parts of polyether ketone, 4-9 parts of methylsuccinic anhydride, 4-8 parts of sodium p-styrenesulfonate, 3-7 parts of fucose, 4-8 parts of aspartic acid, 6-13 parts of 1,5-dimercaptopentane, 2-6 parts of 2-(2-ethoxy carbonyl allyloxy) ethylphosphonic acid, 3-7 parts of tetrabenzylthiuramdisulfide, 3-6 parts of polymethylhydrosiloxane, 4-8 parts of vitamin A palmitate, 5-9 parts of benzoyl peroxide, 4-8 parts of nano-zinc oxide and 15-23 parts of glycerinum. The prepared medicine rubber plug material is high in officinal compatibility and leakproofness and suitable for the pharmaceuticals industry as the rubber plug material is safe, stable and high in compatibility.

Description

technical field

[0001] The invention belongs to the field of medical materials, and in particular relates to a safe and stable medical rubber stopper material and a preparation method thereof. Background technique

[0002] Pharmaceutical packaging is one of the most important links in the medical industry. Due to the particularity of medical drugs, a good sealing effect is required to prevent the volatilization or leakage of medicines. In the sealing process of medicines, synthetic rubber plugs are most used. Can play a very good sealing effect. Common medical rubber stopper materials are mainly butyl rubber or halogenated butyl rubber, of which butyl rubber has good elasticity and barrier properties, and has good resistance to heat, ozone and chemicals. Among them, due to the compatibility problems with different degrees of drugs, unstable extracts or extracts are often produced, resulting in unstable physical properties of the rubber stopper. At the same time, some drugs ...

Examples

Embodiment 1

[0020] A method for preparing a safe and stable medical rubber stopper material, comprising the following preparation steps:

[0021] Step 1. Weigh each raw material by mass parts: 42 parts of butyl rubber, 14 parts of silicone rubber, 6 parts of polyether ketone, 4 parts of methyl succinic anhydride, 4 parts of sodium styrene sulfonate, 3 parts of fucose, 4 parts of aspartic acid, 6 parts of 1,5-pentanedithiol, 2 parts of 2-(2-ethoxycarbonylallyloxy) ethylphosphonic acid, 3 parts of tetrabenzylthiuram disulfide, poly 3 parts of methyl hydrogen siloxane, 4 parts of vitamin A palmitate, 5 parts of benzoyl peroxide, 4 parts of nano zinc oxide, 15 parts of glycerin;

[0022] Step 2. Add butyl rubber and aspartic acid to the internal mixer, first banbury at 105°C for 10 minutes; then add silicone rubber, and then banbury at 125°C for 10 minutes to obtain the banbury;

[0023] Step 3, mix the banburying material of step 2 with polyether ketone, methyl succinic anhydride, sodium st...

Embodiment 2

[0026] A method for preparing a safe and stable medical rubber stopper material, comprising the following preparation steps:

[0027] Step 1. Weigh each raw material in parts by mass: 56 parts of butyl rubber, 20 parts of silicone rubber, 11 parts of polyether ketone, 9 parts of methyl succinic anhydride, 8 parts of sodium styrene sulfonate, 7 parts of fucose, 8 parts of aspartic acid, 13 parts of 1,5-pentanedithiol, 6 parts of 2-(2-ethoxycarbonylallyloxy) ethylphosphonic acid, 7 parts of tetrabenzylthiuram disulfide, poly 6 parts of methyl hydrogen siloxane, 8 parts of vitamin A palmitate, 9 parts of benzoyl peroxide, 8 parts of nano zinc oxide, 23 parts of glycerin;

[0028] Step 2. Add butyl rubber and aspartic acid to the internal mixer, first banbury at 128°C for 20 minutes; then add silicone rubber, and then banbury at 140°C for 30 minutes to obtain the banbury;

[0029] Step 3, mix the banburying material of step 2 with polyether ketone, methyl succinic anhydride, sodi...

Embodiment 3

[0032] A method for preparing a safe and stable medical rubber stopper material, comprising the following preparation steps:

[0033] Step 1. Weigh each raw material according to parts by mass: 49 parts of butyl rubber, 17 parts of silicone rubber, 8 parts of polyether ketone, 6 parts of methyl succinic anhydride, 6 parts of sodium styrene sulfonate, 5 parts of fucose, 6 parts of aspartic acid, 10 parts of 1,5-pentanedithiol, 4 parts of 2-(2-ethoxycarbonylallyloxy) ethylphosphonic acid, 5 parts of tetrabenzylthiuram disulfide, poly 4 parts of methyl hydrogen siloxane, 6 parts of vitamin A palmitate, 7 parts of benzoyl peroxide, 6 parts of nano zinc oxide, 19 parts of glycerin;

[0034] Step 2. Add butyl rubber and aspartic acid to the internal mixer, first banbury at 116°C for 15 minutes; then add silicone rubber, and then banbury at 132°C for 20 minutes to obtain the banbury;

[0035] Step 3, mix the banburying material of step 2 with polyether ketone, methyl succinic anhydr...

technical field

[0001] The invention belongs to the field of medical materials, and in particular relates to a safe and stable medical rubber stopper material and a preparation method thereof. Background technique

[0002] Pharmaceutical packaging is one of the most important links in the medical industry. Due to the particularity of medical drugs, a good sealing effect is required to prevent the volatilization or leakage of medicines. In the sealing process of medicines, synthetic rubber plugs are most used. Can play a very good sealing effect. Common medical rubber stopper materials are mainly butyl rubber or halogenated butyl rubber, of which butyl rubber has good elasticity and barrier properties, and has good resistance to heat, ozone and chemicals. Among them, due to the compatibility problems with different degrees of drugs, unstable extracts or extracts are often produced, resulting in unstable physical properties of the rubber stopper. At the same time, some drugs ...

Examples

Embodiment 1

[0020] A method for preparing a safe and stable medical rubber stopper material, comprising the following preparation steps:

[0021] Step 1. Weigh each raw material by mass parts: 42 parts of butyl rubber, 14 parts of silicone rubber, 6 parts of polyether ketone, 4 parts of methyl succinic anhydride, 4 parts of sodium styrene sulfonate, 3 parts of fucose, 4 parts of aspartic acid, 6 parts of 1,5-pentanedithiol, 2 parts of 2-(2-ethoxycarbonylallyloxy) ethylphosphonic acid, 3 parts of tetrabenzylthiuram disulfide, poly 3 parts of methyl hydrogen siloxane, 4 parts of vitamin A palmitate, 5 parts of benzoyl peroxide, 4 parts of nano zinc oxide, 15 parts of glycerin;

[0022] Step 2. Add butyl rubber and aspartic acid to the internal mixer, first banbury at 105°C for 10 minutes; then add silicone rubber, and then banbury at 125°C for 10 minutes to obtain the banbury;

[0023] Step 3, mix the banburying material of step 2 with polyether ketone, methyl succinic anhydride, sodium st...

Embodiment 2

[0026] A method for preparing a safe and stable medical rubber stopper material, comprising the following preparation steps:

[0027] Step 1. Weigh each raw material in parts by mass: 56 parts of butyl rubber, 20 parts of silicone rubber, 11 parts of polyether ketone, 9 parts of methyl succinic anhydride, 8 parts of sodium styrene sulfonate, 7 parts of fucose, 8 parts of aspartic acid, 13 parts of 1,5-pentanedithiol, 6 parts of 2-(2-ethoxycarbonylallyloxy) ethylphosphonic acid, 7 parts of tetrabenzylthiuram disulfide, poly 6 parts of methyl hydrogen siloxane, 8 parts of vitamin A palmitate, 9 parts of benzoyl peroxide, 8 parts of nano zinc oxide, 23 parts of glycerin;

[0028] Step 2. Add butyl rubber and aspartic acid to the internal mixer, first banbury at 128°C for 20 minutes; then add silicone rubber, and then banbury at 140°C for 30 minutes to obtain the banbury;

[0029] Step 3, mix the banburying material of step 2 with polyether ketone, methyl succinic anhydride, sodi...

Embodiment 3

[0032] A method for preparing a safe and stable medical rubber stopper material, comprising the following preparation steps:

[0033] Step 1. Weigh each raw material according to parts by mass: 49 parts of butyl rubber, 17 parts of silicone rubber, 8 parts of polyether ketone, 6 parts of methyl succinic anhydride, 6 parts of sodium styrene sulfonate, 5 parts of fucose, 6 parts of aspartic acid, 10 parts of 1,5-pentanedithiol, 4 parts of 2-(2-ethoxycarbonylallyloxy) ethylphosphonic acid, 5 parts of tetrabenzylthiuram disulfide, poly 4 parts of methyl hydrogen siloxane, 6 parts of vitamin A palmitate, 7 parts of benzoyl peroxide, 6 parts of nano zinc oxide, 19 parts of glycerin;

[0034] Step 2. Add butyl rubber and aspartic acid to the internal mixer, first banbury at 116°C for 15 minutes; then add silicone rubber, and then banbury at 132°C for 20 minutes to obtain the banbury;

[0035] Step 3, mix the banburying material of step 2 with polyether ketone, methyl succinic anhydr...

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