Blood coagulant and preparation method thereof

A technology of blood coagulant and isopropanol, which is applied in the field of blood coagulant, can solve problems such as difficulty in satisfying rapid laboratory testing, inaccurate test results, and interference of test results, so as to prevent blood from hanging on the wall and promote blood circulation. Solidification, long-term effect

Inactive Publication Date: 2016-11-16
HEBEI XINLE MEDICAL EQUIP SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under normal circumstances, it takes more than 60 minutes for the blood sample to completely coagulate after being isolated, which is difficult to meet the needs of the laboratory for rapid detection
[0003] At present, in clinical serum biochemical testing, a coagulant is added to the blood to shorten the coagulation time. The traditional coagulant is kaolin, cephalin and thrombin, but the first two components will interfere with the test results, resulting in The test results are inaccurate, and thrombin needs to be equipped with special equipment, which costs a lot

Method used

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  • Blood coagulant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Measure 2ml of α-hydrogen-ω-hydroxy (oxy-1,2-ethylenediyl) polymer, 3.5g of polyvinylpyrrolidone and 1000ml of isopropanol, mix them, and use a high-shear disperser to mix well until the mixed solution Clear and transparent to obtain mixed liquid A;

[0020] Measure 60 ml of polysorbate, 30 ml of polysorbate, and 10.5 g of silica powder, mix, stir, and then use a high-pressure homogenizer for three times of homogenization to obtain a mixture B;

[0021] (3) Mix the mixture A obtained in step (1) and the mixture B obtained in step (2), shake it well, and it is enough.

Embodiment 2

[0023] Measure 3ml α-hydrogen-ω-hydroxy (oxy-1,2-ethylenediyl) polymer, 3g polyvinylpyrrolidone and 1000ml isopropanol, mix them, use a high shear disperser to mix well, until the mixed solution is clear Transparent, get mixed solution A;

[0024] Measure 80ml of polysorbate, 40ml of polysorbate, and 6g of silica powder, mix, stir, and then use a high-pressure homogenizer to homogenize three times to obtain a mixture B;

[0025] (3) Mix the mixture A obtained in step (1) and the mixture B obtained in step (2), shake it well, and it is enough.

Embodiment 3

[0027] Measure 1ml α-hydrogen-ω-hydroxy (oxy-1,2-ethylenediyl) polymer, 5g polyvinylpyrrolidone and 1000ml isopropanol, mix them, use a high shear disperser to mix well until the mixed solution is clear Transparent, get mixed solution A;

[0028] Measure 40ml of polysorbate, 20ml of polysorbate and 15g of silica powder and mix, stir, and then use a high-pressure homogenizer to homogenize three times to obtain a mixture B;

[0029] (3) Mix the mixture A obtained in step (1) and the mixture B obtained in step (2), shake it well, and it is enough.

[0030] Effect example

[0031] Spray the coagulant obtained in Examples 1, 2 and 3 on the inner wall of the blood collection container, spray 25μL on each blood collection tube, then dry it with hot air, and perform vacuum plugging according to the specifications of 5ml to complete the blood collection tube Manufactured for subsequent use.

[0032] Use the prepared blood collection tubes to collect venous blood specimens. Collect 5ml from eac...

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Abstract

The invention relates to a blood coagulant and a preparation method thereof. The blood coagulant comprises polymer of alpha-hydro-omega-hydroxyl (oxy-1,2-ethanediyl), polyvinylpyrrolidone, polysorbate, polysorbate, silicon dioxide powder and isopropyl alcohol. The coagulant obtained can effectively shorten the time for blood coagulation, cannot enable blood to attach to the vascular wall, cannot interfere with results of biochemical test and immunological test, is long in period of validity and has excellent performance.

Description

Technical field [0001] The invention belongs to the technical field of blood coagulation accelerators, and relates to a blood coagulation accelerator and a preparation method thereof. Background technique [0002] Serum refers to the light yellow transparent liquid separated from fibrinogen after blood clotting. Its main function is to provide basic nutrients, provide hormones and various growth factors, provide binding proteins, provide contact promotion and stretch factors. Cells adhere to the wall from mechanical damage and have certain protective effects on the cells in culture. It is one of the main specimens tested in clinical biochemical and immunological tests. In general, it takes more than 60 minutes for an isolated blood sample to completely coagulate, which is difficult to meet the needs of rapid laboratory testing. [0003] At present, in clinical serum biochemical tests, coagulants are added to the blood to shorten the clotting time. Traditional coagulants are kaolin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28
CPCG01N1/28
Inventor 韩永波张鹏飞赵林
Owner HEBEI XINLE MEDICAL EQUIP SCI & TECH
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