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Filtering membrane for endotoxin in water for dialyzate and manufacturing method of filtering membrane

A manufacturing method and dialysate technology, applied in the field of hemodialysis, can solve the problems of improvement, large liquid transmembrane resistance, unfavorable membrane permeability, etc., and achieve good liquid permeability, high mechanical strength and chemical stability, and interception. high rate effect

Active Publication Date: 2016-11-23
WEIHAI WEIGAO BLOOD PURIFICATION PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this structure can only effectively intercept viruses above 20nm, and due to the similar porosity in the membrane thickness direction, the liquid transmembrane resistance is relatively large, which is not conducive to the improvement of membrane permeability

Method used

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  • Filtering membrane for endotoxin in water for dialyzate and manufacturing method of filtering membrane

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Effect test

Embodiment 1

[0028] A membrane for filtering endotoxin in water for dialysate is processed from the following raw materials in proportion by mass: 25 parts of polysulfone, 5 parts of sulfonated polysulfone, 1 part of polyvinylpyrrolidone, and the solvent is selected from dimethylacetamide ( DMAc) 68 parts, water 1 part; the membrane structure of the polysulfone hollow fiber dialysis membrane is composed of a dense layer with a thickness of 3 μm on the inside and a loose layer with a thickness of 35 μm on the outside. The average pore diameter of the dense layer is 9.8 nm, and the average pore diameter of the loose layer is 95 nm. 28% of its mass in the dense layer is hydrophilic polymer, and 98% of its mass in the loose layer is polysulfone material. The surface of the dense layer is negatively charged, and the surface of the loose layer is positively charged. Among them, the sulfonated polysulfone adopts monomer sulfonation synthesis process known in the art, uses dichlorodiphenyl sulfone ...

Embodiment 2

[0031] A membrane for filtering endotoxin in water for dialysate is processed from the following raw materials in proportion by mass: 25 parts of polysulfone, 5 parts of sulfonated polysulfone, 1 part of polyvinylpyrrolidone, and the solvent is selected from dimethylacetamide ( DMAc) 68 parts, water 1 part; the membrane structure of the polysulfone hollow fiber dialysis membrane is composed of a dense layer with a thickness of 1.2 μm on the inside and a loose layer with a thickness of 31 μm on the outside. The average pore size of the dense layer is 10.9 nm, and the average pore size of the loose layer is 103 nm. 22% of the mass in the dense layer is hydrophilic polymer, and 91% of the mass in the loose layer is polysulfone material. The surface of the dense layer is negatively charged, and the surface of the loose layer is positively charged. Among them, the degree of sulfonation of sulfonated polysulfone is 20%. Its manufacturing method is as follows: select raw materials ac...

Embodiment 3

[0033] A filter membrane for endotoxin in water for dialysate, which is processed from the following raw materials in proportion by mass: 25 parts of polyethersulfone, 5 parts of sulfonated polyethersulfone, 1 part of polyvinylpyrrolidone, dimethyl ethyl ether as a solvent Amide (DMAc) 68 parts, water 1 part. The membrane structure of the polysulfone hollow fiber dialysis membrane consists of a dense layer with a thickness of 3.8 μm on the inside and a loose layer with a thickness of 36 μm on the outside. The average pore size of the dense layer is 10.3 nm, and the average pore size of the loose layer is 112 nm. In the dense layer, 25% of its mass is Hydrophilic polymer, 96% of its mass in the loose layer is polysulfone material, the surface of the dense layer is negatively charged, and the surface of the loose layer is positively charged. Among them, the degree of sulfonation of sulfonated polysulfone is 10%.

[0034] Its manufacturing method is as follows: select raw materi...

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Abstract

The invention discloses a filtering membrane for endotoxin in water for dialyzate and a manufacturing method of the filtering membrane, and relates to the technical field of hemodialyses. The filtering membrane is processed from the following raw materials in parts by mass: 5 to 40 parts of a polysulfone material, 1 to 50 parts of a hydrophilic polymer, 1 to 20 parts of a bore-forming additive, and 10 to 200 parts of a solvent; a membrane structure consists of a dense layer with the thickness of 1 to 5 [mu]m on the inner side and a loosened layer with the thickness of 30 to 39 [mu]m on the outer side. The manufacturing method comprises the following steps: introducing a homogeneous solution into a spinning tank; after a vacuum defoaming treatment, extruding the homogeneous solution through a spinning nozzle at the temperature of 20 to 90 DEG C; performing a dry-spinning path of 100 to 1,000 mm, and enabling the extruded filaments to enter a solidifying device for solidifying, wherein a liquid in the solidifying device consists of the water and hydrogen peroxide; then, drying the filaments through a drying device; finally, collecting the filaments by adopting winding equipment to prepare a finished product. The filtering membrane for the endotoxin in the water for the dialyzate has the advantages of high mechanical strength, high chemical stability, high endotoxin and bacterium retention rate and the like.

Description

technical field [0001] The invention relates to the technical field of hemodialysis, and specifically relates to an endotoxin filter membrane in water for dialysate with high mechanical strength and chemical stability, good liquid permeability and high endotoxin retention rate and a manufacturing method thereof. Background technique [0002] At present, there are about 100 million patients with chronic kidney disease and about 3 million patients with end-stage renal disease in my country, but only more than 300,000 patients can receive effective dialysis treatment. With the popularization of medical insurance in the field of blood purification, my country will become the largest hemodialysis market in the world, and its market size is estimated to account for more than half of the world. Now, the annual cost of hemodialysis in my country is as high as 30 billion yuan, and it is expected to reach a market size of 100 billion yuan by 2020. Patients need to use 120~150L of dia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/12B01D71/68B01D67/00
CPCB01D67/0016B01D69/12B01D71/68B01D2325/14
Inventor 牟倡骏徐天成王振华代朋李领军曲佳伟
Owner WEIHAI WEIGAO BLOOD PURIFICATION PROD
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