Aza-naphthyl imide Cd<2+> probe molecule, synthesis method therefor and application of aza-naphthyl imide Cd<2+> probe molecule
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of xinaphthimide and probe molecules, applied in chemical instruments and methods, analytical materials, fluorescence/phosphorescence, etc., can solve problems such as interference and poor interference, achieve high selectivity and sensitivity, and have a wide range of potential application values Effect
Inactive Publication Date: 2016-11-30
QIQIHAR UNIVERSITY
View PDF1 Cites 4 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] The present invention is to solve the existing detection Cd 2+ Molecular probes susceptible to Zn 2+ Interference, anti-Zn 2+ Inte
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
specific Embodiment approach 1
[0024] Specific embodiment one: the azanaphthimide Cd of the present embodiment 2+ Probe molecule, its structural formula is:
[0025]
[0026] Wherein, said R is a C1-C4 linear alkyl group.
specific Embodiment approach 2
[0027] Specific embodiment two: the azanaphthimide class Cd described in specific embodiment one 2+ The synthetic method of probe molecule is carried out according to the following steps:
[0028] 1. Add pyrano[3,4,5-de]quinoline-2,4,6(1H)-trione and alkylamine to ethanol at a molar ratio of 1:(4.8~5.2) , heated to boiling and refluxed for 4-6 hours under the protection of nitrogen; the reaction solution was spin-dried, and then separated by silica gel column chromatography to obtain intermediate Ⅰ;
[0029] 2. Add intermediate I and phosphorus oxychloride obtained in step 1 to dioxane at a molar ratio of 1:(9.5-10.5), and react for 2-3 hours at 75-85°C; Ammonia water adjusts the pH value of the reaction solution to alkaline; the reaction solution is spin-dried, and then separated by silica gel column chromatography to obtain intermediate II;
[0030] 3. Add intermediate II and 2-aminobenzylamine obtained in step 2 to ethylene glycol methyl ether in a molar ratio of 1: (4.8-...
specific Embodiment approach 3
[0033] Specific embodiment three: the difference between this embodiment and specific embodiment two is: in step one, pyrano[3,4,5-de]quinoline-2,4,6(1H)-trione, alkylamine The molar ratio is 1:5. Others are the same as in the second embodiment.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
Melting point
aaaaa
aaaaa
Login to view more
Abstract
The invention discloses an aza-naphthyl imide Cd<2+> probe molecule, a synthesis method therefor and an application of the aza-naphthyl imide Cd<2+> probe molecule and relates to Cd<2+> probe molecules and synthesis and application thereof. The aza-naphthyl imide Cd<2+> probe molecule is used for solving the technical problem that the Zn<2+> interference resistance of the existing Cd<2+> detecting molecule probes is relatively poor. The aza-naphthyl imide Cd<2+> probe molecule disclosed by the invention has a structural formula represented by a formula shown in the description. A preparation method comprises the steps: subjecting pyrano[3,4,5-de]quinolin-2,4,6(1H)-trione and alkylamine to a reaction in ethanol, and separating an intermediate I; subjecting the intermediate I to a reaction with phosphorus oxychloride, and separating an intermediate II; subjecting the intermediate II to a reaction with 2-amino benzylamine, and separating an intermediate III; subjecting the intermediate III to a reaction with 2-chloroacetyl chloride, and separating an intermediate IV; and finally subjecting the intermediate IV to a reaction with di(2-picolyl)amine, and separating the aza-naphthyl imide Cd<2+> probe molecule. The probe is applied to fluorescence-reinforced detection on Cd<2+> in solutions or cells.
Description
technical field [0001] The present invention relates to Cd 2+ Probe molecules and their synthesis and applications. Background technique [0002] CD 2+ It is a very toxic metal ion, the main metal pollutant in the environment, and has toxic effects on crops and human body. For crops, the light ones will cause the metabolic process in the body to be disordered, which will inhibit the growth of the crops, and the severe ones will cause the death of the crops; for humans, long-term exposure to Cd 2+ It can lead to diseases such as renal impairment, cardiovascular disease, disturbance of calcium metabolism, eosinophilia and certain cancers. Due to Cd 2+ Widely used in batteries, Cd in air, water, and soil 2+ The contamination of Cd is serious, so it is used to identify and detect Cd in environmental samples and living cells 2+ Content probes are particularly important. [0003] However, as mentioned in Chem.Rev., Vol. 114, pp. 4564-4601, 2014, the reported Cd 2+ Molecula...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more