Molecularly imprinted electrochemical sensor based on magnetic mesoporous titanium dioxide material as well as preparation method and application of molecularly imprinted electrochemical sensor

A mesoporous titanium dioxide and molecular imprinting technology, applied in the direction of electrochemical variables of materials, can solve the problems of difficult separation and recovery, long detection period, limited recognition sites for surface molecularly imprinted polymers, etc., and achieve rich and dispersed recognition sites. good effect

Pending Publication Date: 2022-08-09
SHAANXI UNIV OF SCI & TECH
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Problems solved by technology

[0006] The purpose of the present invention is to propose a molecularly imprinted electrochemical sensor of magnetic mesoporous titanium dioxide material and its preparation method and application, in

Method used

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  • Molecularly imprinted electrochemical sensor based on magnetic mesoporous titanium dioxide material as well as preparation method and application of molecularly imprinted electrochemical sensor
  • Molecularly imprinted electrochemical sensor based on magnetic mesoporous titanium dioxide material as well as preparation method and application of molecularly imprinted electrochemical sensor
  • Molecularly imprinted electrochemical sensor based on magnetic mesoporous titanium dioxide material as well as preparation method and application of molecularly imprinted electrochemical sensor

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preparation example Construction

[0056] The present invention also provides a preparation method of a molecularly imprinted electrochemical sensor based on a magnetic mesoporous titanium dioxide material, comprising the following steps:

[0057] Step 1. Preparation of Fe by solvothermal method 3 O 4 magnetic nanoparticles;

[0058] Step 2, by sol-gel method in Fe 3 O 4 The surface of magnetic nanoparticles is coated with silica to obtain magnetic nano-microsphere Fe coated with silica 3 O 4 @SiO 2 ;

[0059] Step 3. By solvothermal method, the silica-coated magnetic nano-microspheres Fe 3 O 4 @SiO 2 The surface is coated with titanium dioxide, the Fe 3 O 4 @SiO 2 Disperse into isopropanol, add diethylenetriamine and tetraisopropyl titanate in turn, move into a stainless steel hydrothermal kettle, and obtain magnetic nanometer microspheres Fe coated with titanium dioxide. 3 O 4 @TiO 2 ; Then magnetically separated, washed, dried and heat-treated to obtain magnetic mesoporous titanium dioxide nan...

Embodiment 1

[0069] In this example, the preparation method of the molecularly imprinted electrochemical sensor based on the magnetic mesoporous titanium dioxide material is described in detail. figure 1 shown, attached figure 1 This is a schematic diagram of the preparation process of the electrochemical sensor based on the magnetic mesoporous molecularly imprinted polymer modification according to the present invention; the specific steps in this embodiment are as follows:

[0070] Step 1. Preparation of Fe by solvothermal method 3 O 4 magnetic nanoparticles;

[0071] Specifically, first, weigh 2.6g anhydrous ferric chloride, 1.0g sodium citrate and 4.0g anhydrous sodium acetate; dissolve the weighed anhydrous ferric chloride, sodium citrate and anhydrous sodium acetate in 80mL of ethylene glycol, sonicated for 30min to fully dissolve to obtain a homogeneous solution;

[0072] Then, the above homogeneous solution was poured into a stainless steel hydrothermal kettle to carry out the ...

Embodiment 2

[0126] The steps of this embodiment are substantially the same as those of embodiment 1, and the difference lies in the ratio of tetracycline, methacrylic acid, ethylene glycol dimethacrylate and azobisisobutyronitrile in step 6.

[0127] Specifically, in step 6, 172 mg of methacrylic acid and TC were dissolved in 50 mL of anhydrous toluene, and under the protection of nitrogen, mechanically stirred for 24 h; 50 mg of RAFT reagent-modified magnetic mesoporous titanium dioxide carrier Fe was added. 3 O 4 @mTiO 2 -CPPA, disperse it in the above-mentioned solution; then add 0.9911g ethylene glycol dimethacrylate and 13mg azobisisobutyronitrile, carry out polymerization reaction under nitrogen atmosphere, obtain reaction product; Washing and vacuum drying to obtain the magnetic mesoporous molecularly imprinted polymer Fe 3 O 4 @mTiO 2 @MIP; where the polymerization temperature was 70 °C and the reaction time was 24 h. The imprinted polymers obtained at different ratios showed...

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Abstract

The invention discloses a molecularly imprinted electrochemical sensor based on a magnetic mesoporous titanium dioxide material as well as a preparation method and application of the molecularly imprinted electrochemical sensor, magnetic mesoporous titanium dioxide is taken as a carrier, surface modification is performed on the mesoporous carrier through a dopamine functionalized RAFT reagent, and finally, a magnetic mesoporous molecularly imprinted polymer can be obtained through RAFT polymerization. An electrochemical sensor with a specific recognition function on tetracycline can be constructed by modifying the magnetic mesoporous molecularly imprinted polymer on the surface of an electrode. According to the invention, a molecularly imprinted polymer layer is prepared through reversible addition-fragmentation chain transfer active free radical polymerization reaction initiated on the surface of a mesoporous titanium dioxide material; the prepared magnetic mesoporous molecularly imprinted polymer shows a regular spherical structure, is good in dispersity and has an obvious multi-layer core-shell structure; the electrochemical sensor disclosed by the invention shows a good selective recognition function on target molecule tetracycline in the presence of structural analogues, and has a wide application prospect in recognition and detection of tetracycline in food.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymers, in particular to a molecularly imprinted electrochemical sensor based on a magnetic mesoporous titanium dioxide material and a preparation method and application thereof. Background technique [0002] Molecularly imprinted polymers (MIPs) are receptors with special affinity and specific recognition function for target compounds. Due to their specific recognition functions, MIPs have a wide range of applications in the field of chemical / biosensors. Bulk polymerization is a traditional method for the preparation of molecularly imprinted polymers. The molecularly imprinted polymers prepared by this method often go through steps such as grinding and sieving. The preparation process is cumbersome, and a large number of recognition sites are embedded, resulting in low recognition efficiency. There is a risk of template molecule leakage during use, which affects the detection res...

Claims

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Application Information

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IPC IPC(8): G01N27/30C08F222/14C08F220/06C08F226/06
CPCG01N27/308C08F222/102C08F220/06C08F226/06
Inventor 邵彦明郑蕊朱莹王鹏赵芝镇安军王海花费贵强
Owner SHAANXI UNIV OF SCI & TECH
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