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Magnetic surface molecularly imprinted polymer and preparation method and application thereof

A surface molecular imprinting and polymer technology, which is applied to the preparation of alkali metal compounds, chemical instruments and methods, and test samples, can solve the problems of limited recognition sites of surface molecular imprinting polymers and difficulty in separation and recovery.

Active Publication Date: 2019-12-03
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the deficiencies and defects existing in the prior art, the purpose of the present invention is to propose a magnetic surface molecularly imprinted polymer and its preparation method and application, so as to solve the problem of limited recognition sites of the surface molecularly imprinted polymer in the prior art, separation and recovery. Difficult technical issues

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  • Magnetic surface molecularly imprinted polymer and preparation method and application thereof
  • Magnetic surface molecularly imprinted polymer and preparation method and application thereof
  • Magnetic surface molecularly imprinted polymer and preparation method and application thereof

Examples

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preparation example Construction

[0035] The present invention also provides a method for preparing a molecularly imprinted polymer on a magnetic surface, comprising the following steps:

[0036] Step 1, prepare Fe by solvothermal method 3 o 4 magnetic nanoparticles;

[0037] Step 2, by sol-gel method in Fe 3 o 4 The surface of the magnetic nanoparticles is coated with silica, and the magnetic nanospheres coated with silica are obtained. 3 o 4 @SiO 2 ;

[0038] Step 3, the magnetic nano-microspheres Fe coated with silicon dioxide 3 o 4 @SiO 2 Disperse in absolute ethanol, add ammonia water and tetrabutyl titanate, and carry out hydrolysis reaction to obtain magnetic nanospheres Fe coated with titanium dioxide. 3 o 4 @TiO 2 ; Then through magnetic separation, washing, drying and heat treatment, the magnetic mesoporous titania nanosphere Fe 3 o 4 @mTiO 2 ;

[0039] Step 4, the magnetic mesoporous titania nano-microspheres Fe 3 o 4 @mTiO 2 Ultrasonic dispersion into anhydrous dichloromethane, a...

Embodiment 1

[0047] This example describes in detail the preparation method of molecularly imprinted polymers on magnetic surfaces, as shown in the attached figure 1 shown, with figure 1 It is a schematic diagram of the preparation process of the molecularly imprinted polymer on the magnetic surface of the present invention; the specific steps in this embodiment are as follows:

[0048] Step 1, adopt solvothermal method to prepare Fe 3 o 4 magnetic nanoparticles;

[0049] Specifically, first, weigh 2.6g anhydrous ferric trichloride, 1.0g sodium citrate and 4.0g anhydrous sodium acetate; dissolve the weighed anhydrous ferric chloride, sodium citrate and anhydrous sodium acetate in In 80mL ethylene glycol, sonicate for 15-30min to fully dissolve and obtain a uniform solution;

[0050] Then, pour the above homogeneous solution into a stainless steel autoclave for reaction; wherein, the reaction temperature is 180-200°C, and the reaction time is 10-24h; after the reaction is completed, coo...

Embodiment 2

[0098] The steps of this embodiment are substantially the same as those of Embodiment 1, except that the ratio of 4-vinylpyridine to ethylene glycol dimethacrylate in step 6 is different.

[0099] Specifically, in step 6, dissolve 0.21g of 4-vinylpyridine and TBBPA in 50mL of anhydrous toluene, and mechanically stir for 12-24h under the protection of nitrogen; add 50mg of RAFT reagent-modified magnetic mesoporous titanium dioxide carrier Fe 3 o 4 @mTiO 2 -CPDB, which is dispersed in the above solution; then add 0.369g ethylene glycol dimethacrylate and 20mg azobisisobutyronitrile, and carry out polymerization reaction under nitrogen atmosphere to obtain the reaction product; adopt ethanol to carry out the reaction product Washing, vacuum drying to obtain the magnetic surface molecularly imprinted polymer Fe 3 o 4 @mTiO 2 @MIP; where the polymerization temperature is 60-70°C and the reaction time is 16-32h. The imprinted polymers obtained at different ratios showed differe...

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Abstract

The invention provides a magnetic surface molecularly imprinted polymer and a preparation method and application thereof. Magnetic mesoporous titanium dioxide is taken as a carrier, surface finish isconducted on the carrier through azido functionalized dopamine, then a RAFT reagent is modified to the surface of the carrier through click chemistry, and finally the magnetic surface molecularly imprinted polymer can be obtained through RAFT polymerization; a molecularly imprinted polymer layer is prepared by surface initiated reversible addition-breaking chain transfer active free radical polymerization; the prepared magnetic surface molecularly imprinted polymer shows a regular spherical structure, good dispersion and an obvious multilayer core-shell structure; the characteristics of mesoporous property of the carrier, high specific surface area and good magnetic response are combined; and the magnetic surface molecularly imprinted polymer shows a good selective recognition function fora targeted molecule TBBPA in the presence of structural analogues, and broad application prospects in recognition and detection of the TBBPA in an environmental system are achieved.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymers, in particular to a magnetic surface molecularly imprinted polymer and its preparation method and application. Background technique [0002] Molecularly imprinted polymers (MIPs) are receptors with special affinity and specific recognition function for target compounds. Due to their specific recognition function, MIPs have a wide range of applications in the field of chemical / biological sensors. Bulk polymerization is a traditional method for preparing molecularly imprinted polymers. The molecularly imprinted polymers prepared by this method often have to go through steps such as grinding and sieving. The preparation process is cumbersome, and a large number of recognition sites are embedded, resulting in low recognition efficiency. There is a risk of template molecules leaking during use, which will affect the detection results. [0003] Surface imprinting refers to impri...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F226/06C08F222/14C08J9/28B01J20/26B01J20/28B01J20/285G01N1/28
CPCC08F292/00C08J9/28B01J20/268B01J20/28009B01J20/285G01N1/28C08J2351/10C08F226/06
Inventor 邵彦明白浩武星辰王海花费贵强李璐璐
Owner SHAANXI UNIV OF SCI & TECH
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