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Xinkeshu capsule preparation method

A technology of Xinkeshu capsules and capsules, which is applied in capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc. It can solve problems such as the inability to show the great advantages of modern preparation methods, avoid bacterial contamination and improve internal quality , The effect of shortening the process flow

Inactive Publication Date: 2016-12-07
HEBEI GOGIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The above-mentioned patent documents discuss the technologies of vacuum belt drying and centrifugal filtration respectively. The main problem is that there is no comprehensive research on advanced modern preparation methods with great potential, such as vacuum belt drying and centrifugal filtration technology, and it is impossible to demonstrate modern preparation methods. The great advantages of the method in specific products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation method of Xinkeshu capsule comprises the following process steps:

[0054] a. Prepare materials

[0055] Sorting, cleaning, cutting and drying of salvia miltiorrhiza, hawthorn, woody fragrance, kudzu root and notoginseng respectively;

[0056] b. Superfine pulverization of Panax notoginseng and woody fragrance

[0057] The notoginseng and woody fragrance treated in step a are made into fine powder of notoginseng and woody fragrance through ultrafine pulverization;

[0058] c. Preparation of mixed thick paste

[0059] After warming the hawthorn and kudzu root treated in step a with ethanol, heat and reflux for extraction, high-speed centrifugation and filtration of the alcohol extract, recovery of ethanol under reduced pressure, concentration to prepare a mixed thick paste with a relative density of 1.35 at a temperature of 20°C;

[0060] d, the preparation of Danshen thick paste

[0061] decocting the Danshen treated in step a with water, centrifugal...

Embodiment 2

[0071] The difference between this embodiment and embodiment 1 is:

[0072] In the step c, the speed of the high-speed centrifugation is 15,000 rpm, and the time is 15 minutes; the process conditions for recovering ethanol under reduced pressure are a temperature of 55° C., a pressure of 0.10 MPa, and a time of 6 hours.

[0073] In the step d, the speed of high-speed centrifugation is 13000 rpm, and the time is 10 minutes. The process conditions for concentration under reduced pressure are that the temperature is 80° C., the pressure is 0.07 MPa, and the time is 6 hours.

[0074] The vacuum drying in the step e adopts a vacuum belt dryer, and the process conditions of the vacuum drying are: pressure 0.005 MPa, temperature 50° C., time 40 minutes, feed rate 60 kg / h, crawler speed 8 cm / min .

[0075] All the other contents are the same as in Example 1.

Embodiment 3

[0077] The difference between this embodiment and embodiment 1 is:

[0078] In the step c, the speed of high-speed centrifugation is 13,500 rpm, and the time is 18 minutes; the process conditions for recovering ethanol under reduced pressure are temperature 53° C., pressure 0.07 MPa, and time 8 hours.

[0079] In the step d, the speed of high-speed centrifugation is 12000 rpm, and the time is 15 minutes. The technological conditions for concentration under reduced pressure are that the temperature is 70° C., the pressure is 0.06 MPa, and the time is 9 hours.

[0080] The vacuum drying in the step e adopts a vacuum belt dryer, and the process conditions of the vacuum drying are: pressure 0.003 MPa, temperature 48° C., time 50 minutes, feed rate 55 kg / h, crawler speed 6 cm / min .

[0081] All the other contents are the same as in Example 1.

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Abstract

The invention belongs to preparation of Chinese traditional patent medicine and particularly relates to a Xinkeshu capsule preparation method. The Xinkeshu capsule preparation method includes: preparing materials; subjecting pseudo-ginseng and radix aucklandiae to superfine grinding; preparing mixed thick paste; preparing salvia miltiorrhiza thick paste; performing vacuum drying to make into capsules and the like. With the method, problems about long production cycle, high energy consumption, low efficiency, poor environment friendliness, complex pelletizatioin, difficulty in storing intermediate goods, proneness to contamination and the like in the prior art are effectively solved, and the Xinkeshu capsule preparation method has the advantages of less loss of effective components, short technological process, low production cost, low energy consumption, easy storage of the intermediate goods, low contamination rate and the like.

Description

technical field [0001] The invention belongs to the preparation of Chinese patent medicines, in particular to a preparation method of Xinkeshu capsules. Background technique [0002] Xinkeshu Capsules are made of five traditional Chinese medicines such as Danshen, Hawthorn, Woody Fragrance, Pueraria Radix, and Panax notoginseng, which can promote blood circulation, remove blood stasis, promote qi and relieve pain. It is used for chest tightness, angina pectoris, high blood pressure, dizziness, headache, neck pain, arrhythmia, and hyperlipidemia caused by qi stagnation and blood stasis type coronary heart disease. The efficacy of the compound traditional Chinese medicine is the result of the joint action of multiple components. In order to better control the contents of Danshen, Muxiang, Pueraria Radix and Panax notoginseng in the preparation, it is necessary to optimize the preparation process of Xinkeshu Capsules. [0003] The quality standard of Xinkeshu Capsules is not i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/48A61P9/10A61P9/12A61P9/06A61P3/06
CPCA61K36/537A61K9/4841A61K36/258A61K36/285A61K36/488A61K36/734A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张四岩赵国强王建允
Owner HEBEI GOGIN PHARMA
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