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Multi-purpose fluorocarbon emulsion and preparation method thereof

A fluorocarbon emulsion, multi-functional technology, applied in the direction of general/multi-functional contrast agent, X-ray contrast agent preparation, emulsion delivery, etc., to achieve the effect of simple preparation method and good stability

Inactive Publication Date: 2016-12-07
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the invention of multi-modality imaging contrast agent makes joint diagnosis possible in the hospital

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a. Weigh 10 parts of n-tetraoctylammonium bromide, dissolve it in 1000 parts of toluene, and add it to 50 parts of chloroauric acid aqueous solution, and stir for 1 h at room temperature on a constant temperature magnetic stirrer;

[0023] b. Take 20 parts of n-dodecanethiol and dissolve it in toluene with a mass fraction of 1000 parts, add it to the solution described in a, and stir on a constant temperature magnetic stirrer at room temperature for 10 minutes to obtain a colorless and slightly turbid solution. After the stirring is completed , and then continue to stir the above solution in an ice-water bath for 10 min;

[0024] c. Weigh 20 parts of sodium borohydride and dissolve it in deionized water with a mass fraction of 5000 parts. After fully dissolving, add slowly to the solution described in b, then add 100 parts of fluorocarbons, and continue stirring in an ice-water bath for 3 hours ;

[0025] d. After stopping stirring, remove the deionized water, then add...

Embodiment 2

[0029] a. Weigh 20 parts of n-tetraoctylammonium bromide, dissolve it in 1000 parts of toluene, and add it to 50 parts of chloroauric acid aqueous solution, stir at room temperature on a constant temperature magnetic stirrer for 1.5h;

[0030] b. Measure 30 parts of n-dodecanethiol and dissolve it in toluene with a mass fraction of 1000 parts, add it to the solution described in a, and stir on a constant temperature magnetic stirrer at room temperature for 20 minutes to obtain a colorless and slightly turbid solution. After the stirring is completed , and then continue to stir the above solution in an ice-water bath for 20 minutes;

[0031] c. Weigh 30 parts of sodium borohydride and dissolve it in deionized water with a mass fraction of 5000 parts. After fully dissolving, add slowly to the solution described in b, then add 150 parts of fluorocarbons, and continue stirring in an ice-water bath for 1 -5h;

[0032] d. After stopping stirring, remove the deionized water, then ad...

Embodiment 3

[0036] a. Weigh 30 parts of n-tetraoctylammonium bromide, dissolve it in 1000 parts of toluene, and add it to 30-100 parts of chloroauric acid aqueous solution, and stir for 1 h at room temperature on a constant temperature magnetic stirrer;

[0037] b. Take 20 parts of n-dodecanethiol and dissolve it in toluene with a mass fraction of 1000 parts, add it to the solution described in a, and stir on a constant temperature magnetic stirrer at room temperature for 30 minutes to obtain a colorless and slightly turbid solution. After the stirring is completed , and then continue to stir the above solution in an ice-water bath for 30 minutes;

[0038] c. Weigh 60 parts of sodium borohydride and dissolve it in deionized water with a mass fraction of 5000 parts. After fully dissolving, add slowly to the solution described in b, then add 200 parts of fluorocarbons, and continue stirring in an ice-water bath for 4 hours ;

[0039] d. After stopping stirring, remove the deionized water, ...

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Abstract

The invention provides a multi-purpose fluorocarbon emulsion and a preparation method of the multi-purpose fluorocarbon emulsion. The preparation method comprises the following steps: dissolving n-tetraoctyl ammonium bromide in methylbenzene, adding the obtained solution into chloroauric acid aqueous solution, and carrying out stirring; dissolving n-dodecyl mercaptan in methylbenzene, carrying out stirring, dissolving sodium borohydride in deionized water, after complete dissolving, adding with a fluorocarbon compound, and carrying out ice-water bath stirring; after stirring, removing the deionized water, washing residues, adding anhydrous ethanol into the obtained solution, carrying out standing for overnight precipitation at -20 DEG C, carrying out centrifugation, collecting precipitate, and carrying out drying; and adding normal saline into dipalmitoyl phosphatidyl choline, glycerinum, phospholipids and tocopherol (VE) for dissolving, and taking the supernate, thus obtaining the multi-purpose fluorocarbon emulsion. The prepared fluorocarbon emulsion is uniform in grain diameter, small in size, and good in dispersibility.

Description

[0001] The invention relates to a novel fluorocarbon emulsion with CT and ultrasonic imaging functions, and a preparation method of the fluorocarbon emulsion. Background technique [0002] Acoustic contrast agents used in ultrasonic diagnosis are mainly microbubble contrast agents wrapped with inert gas. The inert gas wrapped inside has a large molecular weight. This type of contrast agent has low solubility, good stability, and microbubbles can generate better harmonic signals. Features. However, its resolution is not high, and the imaging effect on deep-level parts is not good. In recent years, the use of nano-scale fluorocarbons in ultrasound contrast agents has received more and more attention. Its advantages are: ①The imaging principle is aggregation imaging, that is, when the contrast agent is free in the blood circulation, it only appears as an echo pole. Only after a large number of small scatterers gather in the lesion, will they produce significantly enhanced echo s...

Claims

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Application Information

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IPC IPC(8): A61K49/04A61K49/22
CPCA61K49/0002A61K49/04A61K49/226
Inventor 何丹农朱君易帆乔宇王杰金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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