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Microsphere with Raman activity and preparation method thereof

A Raman-active, microsphere technology, applied in the fields of biological monitoring and medical treatment, can solve the problems of poor repeatability, poor stability, and inability to obtain Raman-enhanced signals.

Active Publication Date: 2016-12-07
SOUTH CHINA NORMAL UNIVERSITY +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the above-mentioned patent, metal nanoparticles are deposited on the surface of microspheres by in-situ chemical reaction method. The shape and uniformity of the metal particles are poor, so it is impossible to obtain a stable and orderly distributed controllable "hot spot" site. The so-called "hot spot" site refers to the site between the slits of the metal nanostructure that contributes to the Raman spectral enhancement effect. The uneven and stable distribution of "hot spot" bits will result in poor repeatability, poor stability, and low signal enhancement effect of the generated Raman-enhanced signal

Method used

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  • Microsphere with Raman activity and preparation method thereof
  • Microsphere with Raman activity and preparation method thereof
  • Microsphere with Raman activity and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Preparation of microspheres with nanoarray structure surface

[0031] Hexadecane containing 20 wt% surfactant Span80 and 5 wt% 2,2-diethoxyacetophenone initiator as the oil phase will contain 14 w / v% SiO 2 The aqueous solution of N,N isopropylacrylamide monomer of nanoparticles (with a particle size of 378 nm) was used as the aqueous phase, and the cross-linking agent N’N-methylenebisacrylamide was added thereto. The above-mentioned two-phase fluid is introduced into the flow-focused microfluidic chip of polydimethylsiloxane through a fluid pump to prepare monodisperse droplets. Since the droplets are wrapped with a certain concentration of nanoparticles, due to the influence of nanoparticles The electrostatic repulsion between them and the reduction of the free energy on the surface of the droplet make the nanoparticles arranged in an orderly manner on the surface of the micron droplet to form a nano-hexagonal array pattern, and irradiate with UV light to obtain a ...

Embodiment 2

[0037] This example is basically the same as Example 1, except that in this example, the preparation of the microspheres with nano-array structure surface is to use the method of interfacial self-assembly to prepare monodisperse microspheres with nanoparticle arrays on the surface.

[0038] The specific steps of the method of interfacial self-assembly are as follows: first, put the above-mentioned oil-water two-phase fluid in a beaker according to a certain volume ratio, stir at room temperature, emulsify to obtain a large number of droplets, and then the droplets are wrapped Driven by the liquid-liquid interfacial tension and electrostatic interaction, the nanoparticles are arranged on the surface of the droplet, forming a droplet whose surface is modified by the nanoarray structure. Then ultraviolet light irradiates the liquid droplets, solidifies, and obtains monodisperse microspheres with nanoparticle arrays on the surface, and then deposits a layer of metal layer on the su...

Embodiment 3

[0040] Hexadecane containing 20 wt% surfactant Span80 and 5 wt% 2,2-diethoxyacetophenone initiator as the oil phase will contain 14 w / v% SiO 2 The aqueous solution of N,N isopropylacrylamide monomer of nanoparticles (with a particle size of 378 nm) was used as the aqueous phase, and the cross-linking agent N’N-methylenebisacrylamide was added thereto. The above-mentioned two-phase fluid is introduced into the flow-focused microfluidic chip of polydimethylsiloxane through a fluid pump to produce a monodisperse emulsion, followed by UV curing to obtain microspheres with nano-arrays on the surface, and then used The magnetron sputtering method precisely controls the deposition time and deposits metal layers of different thicknesses on the surface of the microspheres to adjust the size of the slit between the metal and nanoparticles. Figure 5 The surface topography of the nano-arrays deposited on the surface of the microsphere at 103 nm, 205 nm, and 351 nm is shown, from Figure...

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Abstract

The invention discloses a microsphere with a Raman activity and a preparation method of the microsphere with the Raman activity. The method comprises the following steps: preparing monodisperse microspheres of which the surfaces are modified with dielectric nanoparticle arrays; depositing one metal layer on the surface of the nanoparticle array of each prepared monodisperse microsphere; the structure of the microsphere with the Raman activity prepared by the method is that one metal layer is deposited on the nanoparticle array modified on the surface of each monodisperse microsphere to obtain one nano-array encapsulated on the outer surface of each nanoparticle, the shapes and particle sizes of the nanoparticles of the microspheres and the sizes of slits among the nanoparticles and the thickness of the metal layer can be accurately controlled, the microsphere with the Raman activity disclosed by the invention can obtain stably and orderly distributed 'hotspot' positions, so that generated Raman enhanced signals are high in strength, good in repeatability and good in stability; furthermore, the size of each microsphere is uniform and controllable, thus each microsphere can be used as an independent microsphere substrate with the Raman activity.

Description

technical field [0001] The invention relates to the technical fields of biological monitoring and medical treatment, in particular to a microsphere with Raman activity and a preparation method thereof. Background technique [0002] Surface Enhanced Raman Scattering Effect (SERS, Surface Enhanced Raman Spectrum) refers to the pulling of adsorbed molecules due to the enhancement of the electromagnetic field on the surface or near the surface of the sample in the specially prepared surface or sol of some metal good conductors. The phenomenon that the Raman scattering signal is greatly enhanced compared with the ordinary Raman scattering signal. Surface-enhanced Raman can overcome the shortcomings of low sensitivity of Raman spectroscopy, and can obtain structural information that is not easily obtained by conventional Raman spectroscopy. It has attracted extensive attention in chemical analysis, environmental detection, and biological diagnosis. In the enhancement effect of Ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02G01N21/65
CPCB01J13/02G01N21/658
Inventor 水玲玲王娟金名亮龚颖欣周国富
Owner SOUTH CHINA NORMAL UNIVERSITY
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