Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of compound folium isatidis extract

A Folium Folium extract and technology of Folium Folium, applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve the problems of high viscosity of materials, difficult extract drying process, and difficult to dry completely

Inactive Publication Date: 2016-12-21
华夏国药(菏泽)制药有限公司
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are some defects in the preparation method recorded in the above-mentioned standards at present: the drying process of the extract is difficult, and when the vacuum drying method is adopted, after the liquid extract is put into the baking tray, it is difficult to dry thoroughly because the liquid extract is too viscous, and it becomes In the form of a whole block, it is difficult to discharge and crush; when the spray drying method is used, the atomization is difficult due to the high viscosity of the material, and the atomizer is often blocked

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] In the preparation method according to the present invention, after the boiled liquid in step 1) is concentrated into a thick paste with a density of 1.00g / ml to 1.10g / ml, the alcohol precipitation step is used for processing, wherein the weight percentage is 95% The mixed solvent of ethanol and edible glycerin is used as an alcohol precipitating agent. By adjusting the amount of edible glycerin, the viscosity and density of the thick paste obtained by concentrating the supernatant in the later stage can be effectively adjusted, thereby effectively solving the problems in spray drying or vacuum drying. The problem.

[0015] The volume ratio of the 95% by weight ethanol to edible glycerin is 9.9:0.1 to 7:3, preferably 9.5:0.5 to 8:2, most preferably 9:1. When the volume ratio of the two is higher than 9.9:0.1, that is, insufficient edible glycerin, it is difficult to regulate the viscosity and density of the thick paste, and when the volume ratio of the two is lower than...

Embodiment 1

[0019] 1) Take 60kg of Daqingye, 15kg of notopterygium, 15kg of ginseng, 30kg of honeysuckle, and 15kg of rhubarb, and boil them with 15 times the amount of water for 2 hours. After 12 hours, centrifuge at 2000 rpm, clear and concentrate into a thick paste with a density of 1.00g / ml to 1.10g / ml;

[0020] 2) Add the obtained thick paste into the alcohol sink tank, start stirring and add 270L of 95% ethanol and 30L of edible glycerin dropwise at a speed of 180L per hour (the total amount is 300L, and the volume ratio of ethanol and edible glycerin is 9:1 ), continue to stir for 1 hour, then stand still for 24 hours, separate the impurity precipitate and supernatant;

[0021] 3) The supernatant enters the concentration tank and is concentrated into a thick paste with a relative density of 1.20g / ml to 1.25g / ml, which is then spray-dried to obtain compound Folium folium extract granules.

Embodiment 2

[0023] 1) Take 60kg of Daqingye, 15kg of notopterygium, 15kg of ginseng, 30kg of honeysuckle, and 15kg of rhubarb, add 8 times the amount of water to boil for 1 hour, and let the boiling liquid stand After 12 hours, centrifuge at 2000 rpm, clear and concentrate into a thick paste with a density of 1.00g / ml to 1.10g / ml;

[0024] 2) Add the obtained thick paste into the alcohol sink tank, start stirring and add dropwise 360L of 95% ethanol and 40L of edible glycerin at a speed of 180L per hour (the total amount is 400L, and the volume ratio of ethanol and edible glycerin is 9:1 ), continue to stir for 1 hour, then stand still for 24 hours, separate the impurity precipitate and supernatant;

[0025] 3) The supernatant enters the concentration tank and is concentrated into a thick paste with a relative density of 1.20g / ml to 1.25g / ml, which is then spray-dried to obtain compound Folium folium extract granules.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of a novel compound folium isatidis extract. The preparation method comprises the following steps: 1) decocting folium isatidis, rhizoma seu radix notopterygii, rhizoma bistortae, honeysuckle flowers and radix et rhizoma rhei with water, and conducting concentrating so as to obtain a thick paste; 2) conducting alcohol precipitation on the thick paste by virtue of a mixture of ethanol and edible glycerol, and conducting centrifugalization so as to separate an impurity precipitate and a supernatant; and 3) concentrating the supernatant so as to obtain a thick paste, and conducting spray-drying or vacuum drying and crushing, so that compound folium isatidis extract particles are obtained.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a new preparation method of a compound Folium folium extract. Background technique [0002] Compound Folium Folium Extract is brown (brown) powder, slightly sour, bitter, astringent, and hygroscopic. Its main scope of application includes: 1. For Staphylococcus aureus, Streptococcus A, and Neisseria meningitidis , Streptococcus pneumoniae, catarrhal coccus, typhoid bacillus, Escherichia coli, influenza bacillus, diphtheria bacillus and Shigella all have certain inhibitory effects, and also have inhibitory effects on Japanese encephalitis virus, mumps virus, influenza virus, etc. 2. It has the effect of killing Leptospira. 3. It has been found to have anti-Escherichia coli O111B4 endotoxin effect through in vivo and in vitro experiments. 4. It has obvious antipyretic effect on infectious fever, and it can cool down quickly and has low toxicity. 5. It has obvious inhibitory e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K36/708A61P31/04A61P31/12A61P29/00
CPCA61K36/855A61K36/195A61K36/237A61K36/315A61K36/355A61K36/704A61K36/708A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 陈长印马朝霞王星星
Owner 华夏国药(菏泽)制药有限公司