Method for determination of propyl aldehyde in electronic cigarette liquid

A technology for e-cigarette liquid and determination method, which is applied to measurement devices, instruments, scientific instruments, etc., can solve the problems of large differences in additives, large differences in matrices, and complex matrices of e-cigarette liquid, and achieve good solubility. , The effect of preventing polymerization and good solubility

Inactive Publication Date: 2016-12-21
ZHENGZHOU TOBACCO RES INST OF CNTC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, due to the wide variety of e-liquid brand specifications and the large differences in the additives of different f

Method used

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  • Method for determination of propyl aldehyde in electronic cigarette liquid
  • Method for determination of propyl aldehyde in electronic cigarette liquid
  • Method for determination of propyl aldehyde in electronic cigarette liquid

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1

[0031] The standard solution of propionaldehyde-2,4-dinitrophenylhydrazone was analyzed by LC-MS / MS. Regression analysis was performed on the peak area ratio of the target compound and the internal standard quantitative ion to the concentration of propionaldehyde to obtain the standard working curve and regression equation of propionaldehyde. The detection limit (LOD) was calculated with 3 times the signal-to-noise ratio (S / N = 3), The specific test results are shown in Table 2:

[0032] Table 2 Test results of standard working solution of propionaldehyde

[0033] Compound

Example Embodiment

[0034] Example 2

[0035] The spike recovery experiment was carried out at three concentration levels of low, medium and high, and each spiked level was repeated 5 times. The recovery and precision of each spiked level were calculated based on the measured amount and spiked amount. The specific results are shown in the following table:

[0036] Table 3 Method recovery rate and repeatability

[0037]

Example Embodiment

[0038] Example 3

[0039] Weigh 0.2 g of a sample of e-cigarette liquid, add 0.6~3.0mL deionized water, 0.4~3.0mL DNPH derivatization reagent and 50~500 µL HClO respectively 4 Aqueous solution, shake well, and place at room temperature for 30-150 min for derivatization. After the reaction, add 50-500 µL of pyridine, add 100 µL of internal standard working solution, and dilute to 10 mL with acetonitrile, shake well, and filter through 0.22 µm organic phase The membrane was analyzed by LC-MS / MS.

[0040] Substituting the target and internal standard quantitative ion pair peak area ratio into the regression equation, the calculated propionaldehyde content in the sample was 0.33 μg / g.

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Abstract

The invention relates to a method for rapid analysis determination of propyl aldehyde in an electronic cigarette liquid, wherein the method comprises the following steps: firstly, adding a dispersing agent into an electronic cigarette liquid sample; then adding a DNPH derivatization reagent and an acid solution, carrying out a derivatization reaction, and then adding an alkaline reagent and an internal standard substance; and finally analyzing and determining the content of propyl aldehyde in the electronic cigarette liquid by LC-MS/MS. The method has the advantages of high sensitivity, strong interference resistance, good repeatability, and simple and fast pretreatment process, and is suitable for detection of a large number of electronic cigarette liquid samples.

Description

technical field [0001] The invention relates to a rapid analysis and determination method for propionaldehyde in electronic cigarette liquid, belonging to the technical field of trace analysis. Background technique [0002] Propionaldehyde is usually a colorless flammable liquid with a pungent odor and is a slightly toxic substance. LD 50 1410 mg / kg (rat oral). Exposure to low concentration is irritating to eyes and nose, exposure to high concentration has anesthetic effect, can cause bronchitis, pneumonia, pulmonary edema, burn eyes and skin, and is easily absorbed through intact skin. [0003] In recent years, with the continuous strengthening of global tobacco control efforts, the sales of traditional cigarettes in some developed countries have shown a certain downward trend, while the global sales of electronic cigarettes have shown a trend of rapid growth. E-cigarettes, also known as electric atomized cigarettes, are electronic devices that deliver nicotine to the re...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 潘立宁孟庆华王洪波郭军伟樊美娟陈黎刘绍锋吕芳贾云祯赵乐刘惠民
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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