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Method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology

An extraction process and response surface method technology, which is applied in the field of optimizing the extraction process parameters of total flavonoids of Angelica sinensis based on response surface method, can solve the problems of less internal quality research and achieve the effect of reliable data analysis

Inactive Publication Date: 2017-01-11
GANSU UNIV OF CHINESE MEDICINE
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Problems solved by technology

"Mingui No. 3" is a new variety of Angelica sinensis bred by heavy ion irradiation biological breeding technology. Its yield is higher than other varieties, but there are few studies on its intrinsic quality.

Method used

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  • Method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology
  • Method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology
  • Method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology

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Embodiment Construction

[0031] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0032] A method based on response surface methodology to optimize the extraction process parameters of total flavonoids of Angelica sinensis. The angelica described in this method is a new variety of Angelica sinensis "Mingui No. 3" bred by heavy ion irradiation biological breeding technology. gelica sinensis (Oliv.) The dry root of Diels is characterized in that: it comprises the following steps:

[0033] Step 1. Medicinal material pretreatment, weighing an appropriate amount of Angelica medicinal material, washing it with water, drying in an oven at 40°C until constant weight, crushing, sieving with a 60-mesh sieve, and weighing 2.0 g of medicinal material powder;

[0034] Step 2: Ultrasound-assisted, ethanol solution extraction of flavonoids in medicinal materials, taking the response value of the total flavonoid extraction rate of Angelica medicinal mate...

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Abstract

The invention discloses a method for optimizing process parameters of angelica sinensis total flavonoid extraction with response surface methodology. According to the method, extraction duration, a solid-liquid ratio and ethanol content with greater influence on the total flavonoid extraction rate are selected on the basis of a single-factor experiment with an ultrasonic assisted extraction method and are investigated, a quadratic polynomial equation model about a relationship between the total flavonoid extraction content and three factors is established with the response surface methodology, a three-dimensional surface diagram is drawn and comprehensively analyzed, and following optimal technological conditions are obtained: the extraction time is 60 min, the solid-liquid ratio is 1:30g / ml, and the ethanol content is 80%. The optimization experiment and the data analysis are performed simply and reliably with central composite design and the response surface methodology by the aid of statistical software Design Expert 7.0.0, the process parameters of the total flavonoid extraction of Mingui No.3 are optimized, and a better effect is realized; with the adoption of the method, reference is provided for evaluation of inherent quality of the Mingui No.3, and a foundation is laid for popularization and application of a new variety of angelica sinensis.

Description

technical field [0001] The invention relates to the technical field of extraction of plant components, in particular to a method for optimizing the extraction process parameters of total flavonoids of angelica based on the response surface method. Background technique [0002] Angelica sinensis Angelica sinensis (Oliv.) The dry root of Diels, warm in nature and sweet in taste, belongs to the liver, heart, and spleen meridians. It is a commonly used blood-enriching medicine in traditional Chinese medicine. Alkalis, organic acids, volatile oils, polysaccharides, etc. As its main pharmacological components, flavonoids have strong physiological activities, such as anti-oxidation, anti-tumor, antibacterial, reducing myocardial oxygen consumption and scavenging free radicals, etc., which can be used as internal quality evaluation indicators of Angelica sinensis. "Mingui No. 3" is a new variety of Angelica sinensis bred by the biological breeding technology of heavy ion irradiat...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232G06F17/50A61K125/00
CPCA61K36/232A61K2236/15A61K2236/333G06F30/20G06F2111/06G06F2119/18
Inventor 李硕李越峰杨扶德吴平安
Owner GANSU UNIV OF CHINESE MEDICINE
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