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Method for preparing stretch-proof medicine-carrying poly(lactic acid-glycolic acid) surgical suture line

A technology of poly(lactic acid glycolic acid) and lactic acid glycolic acid, applied in the field of biomedicine, can solve the problems of limited preparation technology, unsatisfactory mechanical properties of products, limited application of absorbable sutures, etc., and achieves good tensile strength and high molecular weight. Effect

Inactive Publication Date: 2017-01-11
侯英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, my country's absorbable sutures still face three major problems: (1) The preparation process is limited, and the mechanical properties of the products are not satisfactory
For these reasons, the clinical application of absorbable sutures in my country is still relatively limited.

Method used

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  • Method for preparing stretch-proof medicine-carrying poly(lactic acid-glycolic acid) surgical suture line

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for preparing stretch-resistant drug-loaded poly(lactic-co-glycolic acid) surgical sutures, comprising dispersing drug-loaded hollow silicon dioxide submicron spheres in an aqueous solution of stretch-resistant poly(lactic-co-glycolic acid), and spinning the drug-loaded The hollow silicon dioxide submicron spheres are embedded in the stretch-resistant poly(lactic-co-glycolic acid) fibers to make stretch-resistant drug-loaded poly(lactic-co-glycolic acid) surgical sutures; the preparation steps of the stretch-resistant poly(lactic-co-glycolic acid) include:

[0021] 1) using industrial-grade lactic acid aqueous solution and glycolic acid as raw materials, dehydrating and refining under vacuum conditions to obtain lactic acid glycolic acid oligomers;

[0022] 2) mixing the lactic acid glycolic acid oligomer obtained in step 1) with a catalyst, adding it to a reaction vessel, and heating and reacting under vacuum conditions to obtain a polylactic acid glycolic acid...

Embodiment 2

[0033] A method for preparing stretch-resistant drug-loaded poly(lactic-co-glycolic acid) surgical sutures, comprising dispersing drug-loaded hollow silicon dioxide submicron spheres in an aqueous solution of stretch-resistant poly(lactic-co-glycolic acid), and spinning the drug-loaded The hollow silicon dioxide submicron spheres are embedded in the stretch-resistant poly(lactic-co-glycolic acid) fibers to make stretch-resistant drug-loaded poly(lactic-co-glycolic acid) surgical sutures; the preparation steps of the stretch-resistant poly(lactic-co-glycolic acid) include:

[0034] 1) using industrial-grade lactic acid aqueous solution and glycolic acid as raw materials, dehydrating and refining under vacuum conditions to obtain lactic acid glycolic acid oligomers;

[0035] 2) mixing the lactic acid glycolic acid oligomer obtained in step 1) with a catalyst, adding it to a reaction vessel, and heating and reacting under vacuum conditions to obtain a polylactic acid glycolic acid...

Embodiment 3

[0046] A method for preparing stretch-resistant drug-loaded poly(lactic-co-glycolic acid) surgical sutures, comprising dispersing drug-loaded hollow silicon dioxide submicron spheres in an aqueous solution of stretch-resistant poly(lactic-co-glycolic acid), and spinning the drug-loaded The hollow silicon dioxide submicron spheres are embedded in the stretch-resistant poly(lactic-co-glycolic acid) fibers to make stretch-resistant drug-loaded poly(lactic-co-glycolic acid) surgical sutures; the preparation steps of the stretch-resistant poly(lactic-co-glycolic acid) include:

[0047] 1) using industrial-grade lactic acid aqueous solution and glycolic acid as raw materials, dehydrating and refining under vacuum conditions to obtain lactic acid glycolic acid oligomers;

[0048] 2) mixing the lactic acid glycolic acid oligomer obtained in step 1) with a catalyst, adding it to a reaction vessel, and heating and reacting under vacuum conditions to obtain a polylactic acid glycolic acid...

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Abstract

The invention relates to a method for preparing a stretch-proof medicine-carrying poly(lactic acid-glycolic acid) surgical suture line. Medicine-carrying hollow silicon dioxide sub-microspheres are dispersed in a stretch-proof poly(lactic acid-glycolic acid) aqueous solution and embedded into stretch-proof poly(lactic acid-glycolic acid) fibers through a spinning method to prepare the stretch-proof medicine-carrying poly(lactic acid-glycolic acid) surgical suture line. Stretch-proof poly(lactic acid-glycolic acid) is prepared through the steps that 1, an industrial-grade lactic acid aqueous solution and glycollic acid are adopted as raw materials, dehydration refining is carried out under the vacuum condition, and a lactic acid-glycolic acid oligomer is obtained; 2, the lactic acid-glycolic acid oligomer obtained in the step 1 is mixed with a catalyst, the mixture is added into a reaction vessel, heating and reacting are carried out under the vacuum condition, and a poly(lactic acid-glycolic acid) intermediate is obtained; 3, a chain extender TD1 is added into the reaction vessel in the step 2, heating and reacting are carried out under the vacuum condition, and high molecular weight poly(lactic acid-glycolic acid) is obtained.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of stretch-resistant drug-loaded polylactic acid glycolic acid surgical suture. Background technique [0002] At present, the surgical sutures used clinically in China are mainly divided into two types: non-absorbable sutures and absorbable sutures. Non-absorbable sutures include nylon, polypropylene, and polyethylene. These materials are used as surgical sutures with high tensile strength and low tissue response, but the disadvantages are that they are difficult to knot, easy to detach, cannot be degraded and absorbed, and need to be removed. Absorbable sutures include cashmere thread, polyglycolide, chitin, collagen fibers, etc. Advanced absorbable sutures should have strong tensile strength, good handling performance, uniform and stable material, no antigenicity, and low tissue reaction, which is better than non-absorbable sutures. At present, my country's ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/12A61L17/00C08G63/91C08G63/08C08G63/06
CPCA61L17/12A61L17/005A61L2300/622C08G63/06C08G63/08C08G63/912C08L67/04
Inventor 侯英
Owner 侯英