Veterinary levamisole gel implant and preparation method thereof

Abstract

The invention relates to a veterinary levamisole gel implant which is prepared from the following raw materials in parts by weight: 2-5 parts of levamisole hydrochloride, 8-12 parts of polylactic acid, 70-90 parts of benzyl benzoate, 0.01-5 parts of poloxamer 188, 0.01-2 parts of monoethanolamine and 5-20 parts of potassium sorbate. The veterinary levamisole gel implant can simultaneously expel and kill many different kinds of parasites. The veterinary levamisole gel implant has the physicochemical characteristics applicable to group administration, and does not have local stimulation for people subjected to injection administration. The veterinary levamisole gel implant is low in price, and can be subjected to large-scale popularization and application in animal production. After the veterinary levamisole gel implant is applied to food animals, the drugs do no reside in the meat, eggs, milk and products thereof. The veterinary levamisole gel implant is simple in preparation technique and convenient for administration, is capable of prolonging the drug action time, reducing the drug dosage and lowering the side effects of drugs, and can improve the compliance and comfort of patients / applied animals.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a veterinary levamisole gel implant and a preparation method thereof. Background technique [0002] Parasitic diseases are one of the most serious diseases that harm humans and animals. Many of these parasitic diseases are zoonotic. There are no precise statistics on the infection of animals by various parasites in my country. In 1999, a survey by the International Bureau of Epizootics found that worms had become the number one animal disease worldwide. The cost of deworming medicines in the world is as high as 3 billion U.S. dollars every year. It can be seen that active prevention and control of parasitic diseases is of great significance to the protection of human and animal health. Drug control is an important link in the prevention and control of animal parasitic diseases, and has great social and production significance for the development...

AI Technical Summary

Problems solved by technology

[0007] The long-acting injection preparations of antiparasitic drugs currently on the market are mainly traditional dosage forms such as injection oils, suspensions, and slow-release boluses. There are also research reports on injection microspheres, liposomes, and solid implants. They all have shortcomings such as poor preparation stability, complicated preparation process, and relatively large side effects. Traditional emulsions are difficult to become an injection-type long-acting preparation due to stability, toxicity, and easy diffusion into the body fluid environment. It is easily cleared by macrophages, it is difficult to maintain sufficient effective blood drug concentration, poor stability, difficult to sterilize and low drug loading limit its application as an injectable long-acting preparation

Injectable microspheres mainly have problems such as complex preparation process and many steps, which lead to difficult control of parameters, large quality differences between product batches, poor stability and migration from the injection site.

However, traditional implants are inconvenient to administer, and are limited by problems such as local irritation and muscle toxicity.

[0008] Traditional emulsions have problems such as stability, toxicity, and easy diffusion into the body fluid environment, making it difficult to become a long-acting preparation; liposomes are easily cleared by macrophages, and it is difficult to maintain sufficient blood drug concentrations. , and its stability problem, sterilization problem and low drug loading also limit its application as an injection-type long-acting preparation; the problem of injection-type microspheres is mainly that the preparation process is complicated, resulting in difficult control of parameters and product quality. Stability varies greatly, and microspheres still have problems such as sterilization, stability, and migration from the injection site; traditional implants mainly have problems such as inconvenient administration and local muscle toxicity; while injectable suspensions and oils also have problems issues of stability and security

Images