Method for preparing artificial blood vessels

A technology of artificial blood vessels and stem cells, applied in blood vessels, biochemical equipment and methods, devices with human tubular structures, etc., can solve the problems that artificial blood vessels cannot smoothly transport nutrient and metabolic waste, blood vessel blockage, and human arteries and blood vessels cannot be simulated. Layer structure and other issues to achieve the effect of increasing blood compatibility and biological stability

Inactive Publication Date: 2017-02-15
3D GLOBAL BIOTECH
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Problems solved by technology

[0003] However, the artificial blood vessels prepared by the prior art can only form a single-layer structure, and cannot simulate the three-layer structure of human arteries, so it will affect the stability and function of the artificial blood vessels in use
In addition, if the inner wall of the artificial blood vessel with an inner diameter of less than 3 millimeters (mm) grows tissue or forms a thrombus, it will easily cause blood vessel blockage, which will make the artificial blood vessel unable to smoothly transport nutrients, oxygen and remove metabolic waste. Artificial blood vessels with an inner diameter of less than 3 millimeters (mm) have not been used in clinical treatment

Method used

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  • Method for preparing artificial blood vessels

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preparation example

[0018] Preparation example: preparation method of artificial blood vessel

[0019] In an environment of 80°C, liquid agarose was made into agarose fiber by using 3D printing technology, and then the agarose fiber was placed in an environment of 4°C to solidify the agarose fiber to form a template.

[0020] Under helium atmosphere, polycarbonate polyol (polycarbonate polyol) and trans-cyclohexanediolisobutyl-silsesquioxane (trans-cyclohexanediolisobutyl-silsesquioxane) were mixed in a specific volume ratio, Based on volume percentage (vol%), the mixed volume ratio of the polycarbonate polyol and trans-cyclohexanediol isobutyl semisiloxane is 1vol%: 30vol%, and heated at 125°C for 5 minutes to For 10 minutes, the polycarbonate polyol and trans-cyclohexanediol isobutylsemisiloxane were fully dissolved and mixed into a mixture. Cool the mixture to 60°C and mix it with diarylmethane diisocyanate (diphenyl-methane-diisocyanate, MDI) at 1vol%: 4vol% to form a composition; raise the ...

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Abstract

A method for preparing artificial vessels, disclosed by the invention, comprises preparing a template by 3D printing; preparing an active polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (active POSS-PCU); mixing the active POSS-PCU with stem cells to form the artificial vessels by 3D printing followed by plasma processing; removing the template to form the artificial blood vessels with an access. The method provides to prepare the artificial vessels with three-layer structures, which are capable of transporting nutrients and oxygen, removing metabolic wastes and enhancing haemocompatibility and biological stability. Therefore, the method for preparing the artificial vessels solves the problem of angiemphraxis caused by the artificial vessels with single-layer structure.

Description

technical field [0001] The invention relates to a method for preparing artificial blood vessels, in particular to a method for preparing artificial blood vessels with a three-layer structure. Background technique [0002] Biomedical materials used to prepare artificial blood vessels in the prior art include silica gel or polytetrafluoroethylene (polytetrafluoroethylene, PTFE, ), artificial blood vessels made of polytetrafluoroethylene have been used in human brain surgery and heart bypass surgery. The prior art also utilizes coating (coating) technology to combine biomedical materials and cells to prepare artificial blood vessels. This coating technology includes transferring a blood bag rich in cells into a Hollow columns of biomedical materials for cell coating. After the coating is complete, the cells will be in the grows on a hollow column of biomedical materials, allowing cells to gradually replace the biomedical materials and form artificial blood vessels. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38A61L27/18A61L27/50
CPCA61F2/06C12N5/0691C12N13/00C12N2506/1353
Inventor 欧耿良
Owner 3D GLOBAL BIOTECH
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