Gadolinium-containing MRI contrast agents and preparation method of gadolinium-containing MRI contrast agents
A technology of contrast agent and gadolinium oxygen, which is used in nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, pharmaceutical formulations, etc., can solve the problem that rare earth ions cannot be fully utilized, and achieve low toxicity and imaging effect. Good and stable effect
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Embodiment 1
[0021] a. Take 1g gadolinium oxide Gd 2 o 3 , add 2.1617g NH 4 Br (where NH 4 Br and Gd 2 o 3 The ratio of the amount of the substance is 4:1), and then the two are fully ground and mixed in a mortar.
[0022] b. Transfer the mixture obtained in step a to a crucible, shake it tightly, and put it into a muffle furnace. The temperature was kept at 420°C for 2 hours, then raised to 700°C for 2 hours, and pure GdOBr was obtained after cooling to room temperature.
[0023] c. Take 0.5g GdOBr, put it in 100ml sodium benzoate solution (the mass ratio of sodium benzoate to GdOBr is 2:1), microwave the mixture on high heat in a microwave oven (microwave output power is 700W) for 2 minutes, then take out the ice water After cooling down to room temperature, put it in the microwave oven again on high heat for 2 minutes, cool down, and cycle 40 times in this way, wash the obtained sample with water, wash with ethanol, and filter with suction to obtain GdOC after ion exchange between...
Embodiment 2
[0027] a. Take 2g gadolinium oxide Gd 2 o 3 , add 5.4041g NH 4 Br (where NH 4 Br and Gd 2 o 3 The ratio of the amount of the substance is 5:1), and then the two are fully ground and mixed in a mortar.
[0028] b. Transfer the mixture obtained in step a to a crucible, shake it tightly, and put it into a muffle furnace. The temperature was kept at 420°C for 2 hours, then raised to 700°C for 2 hours, and after cooling to room temperature, pure GdOBr was obtained.
[0029] c. Take 1g of GdOBr and place it in 200ml of sodium benzoate solution (the mass ratio of sodium benzoate to GdOBr2 is 2:1), microwave the mixture on high heat in a microwave oven (microwave output power is 700W) for 2 minutes, then take out ice water to cool , after cooling down to room temperature, put it in the microwave oven for 2 minutes on high heat, cool down, and cycle 40 times in this way, wash the obtained sample with water, wash with ethanol, and filter with suction to obtain GdOC after ion excha...
Embodiment 3
[0032] a. Take 2g of rare earth metal salt Gd(NO3) 3 ·6H 2 O was dissolved in a certain amount of 50 ml deionized water. Under magnetic stirring conditions, 0.01M dilute ammonia water was added dropwise to the solution until the pH of the solution was 7, and the stirring was continued for 30 minutes to make it evenly mixed. The above mixture was then placed in a polytetrafluoroethylene-lined hydrothermal kettle and heated at 120 °C for 12 h. Suction filtration, washing with water to remove soluble salts, the product Gd can be obtained 2 (OH) 5 NO 3 2H 2 0.
[0033] b, take 0.5g of the layered substance obtained in a, place it in 100ml sodium benzoate solution (wherein sodium benzoate and Gd 2 (OH) 5 NO 3 2H 20 mass ratio is 2:1), microwave the mixture on high heat in the microwave oven (microwave output power is 700W) for 2 minutes, take out the ice water and cool it down, and put it in the microwave oven again after cooling down to room temperature for 2 minutes, co...
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