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Preparing method of compound alginate anti-adhesion material

A compound alginate and anti-adhesion technology, which is applied in the field of medical biopolymer materials to achieve the effects of inhibiting scar hyperplasia, enhancing anti-adhesion, and enhancing infiltration

Inactive Publication Date: 2017-02-22
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Research reports on anti-adhesion have been reported in various literatures at home and abroad, mainly including film agents and gel agents formed by hyaluronic acid, medical chitosan, polylactic acid, etc., but these methods are often used alone. Nursing The wound also needs to be used in combination with other dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A composite alginate anti-adhesion material is made of the following ingredients in weight percentage: 98% of activated alginate and 2% of composite anti-adhesion film. Among them, the activated alginate is composed of the following preparation steps: (1) cutting the alginate fiber into short fibers with a length of 2~6cm; (2) soaking the above short fibers in 20% potassium periodate activation solution 30min; (3) The activated alginate fibers were ultrasonically oscillated for 3 hours in an ultrasonic wave containing deionized water, and the deionized water was replaced, so repeated three times, and then freeze-dried.

[0027] The preparation process of the composite anti-adhesion material is as follows: (1) Take 20g of a mixture composed of sodium hyaluronate and chitosan (mass ratio 2:1), 1g of polyvinylpyrrolidone, and 0.3g of Dow Corning DC-193 in deionized water Stir well and mix evenly, adjust the pH of the solution to 4 with acetic acid-sodium acetate buffer sol...

Embodiment 2

[0030] A composite alginate anti-adhesion material is made of the following components in weight percentage: 90% of activated alginate and 10% of composite anti-adhesion film. Among them, the activated alginate is composed of the following preparation steps: (1) cutting the alginate fiber into short fibers with a length of 2~6cm; (2) soaking the above short fibers in 80% sodium periodate activation solution 10min; (3) The activated alginate fibers were ultrasonically oscillated for 1h in an ultrasonic wave containing deionized water, and the deionized water was replaced, so repeated three times, and then freeze-dried.

[0031] The preparation process of the composite anti-adhesion material is as follows: (1) Take 30g of a mixture composed of sodium hyaluronate and polylactic acid (mass ratio 1:1), 5g of polyvinylpyrrolidone, and 0.1g of Dow Corning DC-29 in a certain amount of deionized water. Stir and mix evenly, adjust the pH of the solution to 5 with acetic acid-sodium acet...

Embodiment 3

[0034] A composite alginate anti-adhesion material is made of the following ingredients in weight percentage: 95% of activated alginate and 5% of composite anti-adhesion film. Among them, the activated alginate consists of the following preparation steps: (1) cutting the alginate fiber into short fibers with a length of 2 to 6 cm; (2) soaking the above short fibers in 60% potassium periodate activation solution 15min; (3) The activated alginate fibers were ultrasonically oscillated for 2 hours in an ultrasonic wave containing deionized water, and the deionized water was replaced, so repeated three times, and then freeze-dried.

[0035] The preparation process of the composite anti-adhesion material is as follows: (1) Take 10g of chitosan, 3g of polyvinylpyrrolidone, and 0.2g of Dow Corning DC-193 in a certain amount of deionized water, stir and mix evenly, and adjust the concentration of the solution with acetic acid-sodium acetate buffer solution. pH to 3, until the mixture i...

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PUM

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Abstract

The invention provides a preparing method of a compound alginate anti-adhesion material. The compound alginate anti-adhesion material is prepared from, by weight, 90-98% of activated alginate and 2-10% of compound anti-adhesion film, wherein an anti-adhesion agent in a compound anti-adhesion agent and organosilicon surfactant not only have a function of anti-adhesion, but also have functions of bacteriostasis, moisturizing, scar hyperplasia inhibiting and the like, thus an obvious disadvantage that wound adhesion exists in alginate dressing in clinical applications is overcome, medicinal functions of the dressing to some extent are enriched, and applied ranges of the dressing are broadened. A compound alginate anti-adhesion dressing product is simple in processing technology, thus quantity production can be achieved easily, and the dressing product has a very high application value clinically.

Description

technical field [0001] The invention belongs to the field of medical biopolymer materials, and in particular relates to a preparation method of a composite alginate anti-adhesion material. [0002] technical background [0003] Wound adhesion is one of the common complications after abdominal and pelvic surgery, which can cause abdominal discomfort in mild cases and adhesive intestinal obstruction in severe cases. Caesarean section is a commonly used operation in obstetrics, and the rate of cesarean section is increasing year by year, but the intra-abdominal adhesions after the initial operation bring difficulties to the reoperation. With the continuous deepening of the understanding of the formation mechanism of abdominal adhesions, it is now believed that the etiology of adhesions is rarely caused by congenital factors in the abdominal cavity, and the main reason is acquired factors. The common ones are pelvic surgery, infection, bleeding, exudation, accumulation fluid, me...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/24A61L15/42
CPCA61L15/24A61L15/26A61L15/28A61L15/42C08L5/04C08L5/08C08L67/04C08L39/06
Inventor 卢亢陈锦涛庄壮辉熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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