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Method for preparing hydroxyapatite nano rod by adopting hydrothermal method

A technology of hydroxyapatite and nanorods, applied in nanotechnology, chemical instruments and methods, phosphorus compounds, etc., can solve the problems of reducing the repeatability of the preparation process and increasing the complexity of the process, and achieve single shape and high purity , good process repeatability effect

Inactive Publication Date: 2017-02-22
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The pH adjustment process will also increase the complexity of the process and reduce the repeatability of the preparation process

Method used

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  • Method for preparing hydroxyapatite nano rod by adopting hydrothermal method
  • Method for preparing hydroxyapatite nano rod by adopting hydrothermal method
  • Method for preparing hydroxyapatite nano rod by adopting hydrothermal method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Under the condition of high-speed stirring, the phosphoric acid solution was added dropwise into the calcium hydroxide suspension, and reacted for 6 hours. After the reaction, the product was centrifuged, ball milled, and aged.

[0025] The molar ratio of described calcium hydroxide and phosphoric acid is 5:3.

[0026] (2) Centrifuge the aging solution obtained in (1), place the obtained precipitate in a polytetrafluoroethylene-lined hydrothermal kettle, control the volume ratio to 50%, and place the hydrothermal kettle in a 150°C oven for hydrothermal reaction for 5 Hour.

[0027] (3) Cool the hydrothermal kettle after the reaction in (2) to room temperature, wash the precipitate in the kettle with absolute ethanol, and dry at 80°C.

[0028] Observation by transmission electron microscope shows that the obtained hydroxyapatite nanorods have a length of 50-80nm and a diameter of 15-30nm.

Embodiment 2

[0030] (1) Under the condition of high-speed stirring, the phosphoric acid solution was added dropwise into the calcium hydroxide suspension, and reacted for 6 hours. After the reaction, the product was centrifuged, ball milled, and aged.

[0031] The molar ratio of described calcium hydroxide and phosphoric acid is 5:3.

[0032] (2) Centrifuge the aging solution obtained in (1), place the obtained precipitate in a polytetrafluoroethylene-lined hydrothermal kettle, control the volume ratio to 60%, and place the hydrothermal kettle in a 120°C oven for hydrothermal reaction for 5 Hour.

[0033] (3) Cool the hydrothermal kettle after the reaction in (2) to room temperature, wash the precipitate in the kettle with absolute ethanol, and dry at 80°C.

[0034] Observation by transmission electron microscope shows that the obtained hydroxyapatite nanorods have a length of 50-80nm and a diameter of 15-30nm.

Embodiment 3

[0036] (1) Under the condition of high-speed stirring, the phosphoric acid solution was added dropwise into the calcium hydroxide suspension, and reacted for 6 hours. After the reaction, the product was centrifuged, ball milled, and aged.

[0037] The molar ratio of described calcium hydroxide and phosphoric acid is 5:3.

[0038] (2) Centrifuge the aging solution obtained in (1), place the obtained precipitate in a polytetrafluoroethylene-lined hydrothermal kettle, control the volume ratio to 60%, and place the hydrothermal kettle in a 180°C oven for hydrothermal reaction for 5 Hour.

[0039] (3) Cool the hydrothermal kettle after the reaction in (2) to room temperature, wash the precipitate in the kettle with absolute ethanol, and dry at 80°C.

[0040] Observation by transmission electron microscope shows that the obtained hydroxyapatite nanorods have a length of 50-80nm and a diameter of 15-30nm.

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Abstract

The invention relates to a method for preparing a hydroxyapatite nano rod by adopting a hydrothermal method. The method comprises the following steps: (1) under the condition of high-speed stirring, dropwise adding a phosphoric acid solution into a calcium hydroxide suspension for reaction, and centrifuging, ball-milling and aging a product after the end of reaction; (2) centrifuging the product obtained by aging in the step (1), putting a precipitate in a teflon-lined hydrothermal kettle and heating for hydrothermal reaction; (3) cooling the hydrothermal kettle after the end of reaction in the step (2) to a room temperature, and washing and drying the precipitate in the kettle with absolute ethanol. The method provided by the invention has the benefits that any template and surfactant is not used, the pH value of the solution does not require to be adjusted, the hydroxyapatite nano rod is synthesized in one step, the preparation method has the advantages of being simple and easy to implement, low in cost, mild and controllable in conditions and the like, and the prepared hydroxyapatite nano rod is good in dispersibility and single in appearance and can be used as a hard tissue repair material, a drug, a catalytic carrier, a bone cement reinforced material and the like.

Description

technical field [0001] The invention relates to a method for preparing hydroxyapatite nanorods by a hydrothermal method, belonging to the field of preparation of biomedical materials. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) is the main inorganic component of human bones and teeth, has good biocompatibility and biodegradability, and has attracted extensive attention in the field of biomedical materials in recent years. Hydroxyapatite has unique physical and chemical properties and biological characteristics, so it can be used in bone tissue replacement materials, catalysts, ion exchangers and sensors. Nano-hydroxyapatite has a high specific surface area and thus a high drug loading capacity. The development of a simple and green preparation method for hydroxyapatite nanostructures has important research significance and commercial value. [0003] The preparation methods of hydroxyapatite mainly include precipitation method, hydrotherma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00
CPCC01B25/322C01P2002/72C01P2004/04C01P2004/16C01P2004/64
Inventor 董寅生肖夫兰耿银雪郭超储成林盛晓波林萍华
Owner SOUTHEAST UNIV
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