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Method for preparing potassium-containing hydroxyapatite powder

A technology containing potassium hydroxyapatite and potassium hydroxyapatite, which is applied in chemical instruments and methods, phosphorus compounds, and pharmaceutical formulations, and can solve problems such as enhancing bacterial resistance in the oral cavity and causing other oral diseases

Inactive Publication Date: 2017-02-22
SHAANXI SHENGMAI PETROLEUM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the change of people's living environment, dentin hypersensitivity has become a common oral disease. Common oral care products on the market are mainly chemical additives added to toothpaste. Long-term use will enhance the resistance of bacteria in the oral cavity and may cause other diseases. oral disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh Ca(NO 3 ) 2 and H 3 PO 4 Dissolve in 300mL distilled water respectively, then mix the two solutions, stir, filter with suction, centrifuge, and dry to obtain Ca 3 (PO 4 ) 2 powder, put the powder into a crucible, calcined at high temperature, take it out from the furnace immediately, and cool to room temperature to obtain α-Ca 3 (PO 4 ) 2 powder; prepare KOH solution, α-Ca 3 (PO 4 ) 2 Put the powder into the KOH solution, seal the mouth of the beaker with a plastic wrap, place it in an oven, take it out of the oven after 3 days, filter it with suction, wash it, and dry it to obtain potassium-containing hydroxyapatite powder.

Embodiment 2

[0021] Weigh Ca(NO 3 ) 2 and H 3 PO 4 Dissolve in 300mL distilled water respectively, then mix the two solutions, stir, filter with suction, centrifuge, and dry to obtain Ca 3 (PO 4 ) 2 powder, put the powder into a crucible, calcined at high temperature, take it out from the furnace immediately, and cool to room temperature to obtain α-Ca 3 (PO 4 ) 2 powder; prepare KOH solution, α-Ca 3 (PO 4 ) 2 Put the powder into the KOH solution, seal the mouth of the beaker with a plastic wrap, place it in an oven, take it out of the oven after 3 days, filter it with suction, wash it, and dry it to obtain potassium-containing hydroxyapatite powder.

[0022] Among them, the Ca(NO 3 ) 2 and H 3 PO 4 The molar ratio is 3:2. The crucible is a corundum crucible. The temperature of the high-temperature calcination is 1200° C., and the calcination time is 2 hours. The temperature of the oven is 100°C. The stirring speed is 50r / min, and the stirring time is 22min. Pass thr...

Embodiment 3

[0024] Weigh Ca(NO 3 ) 2 and H 3 PO 4 Dissolve in 300mL distilled water respectively, then mix the two solutions, stir, filter with suction, centrifuge, and dry to obtain Ca 3 (PO 4 ) 2 powder, put the powder into a crucible, calcined at high temperature, take it out from the furnace immediately, and cool to room temperature to obtain α-Ca 3 (PO 4 ) 2 powder; prepare KOH solution, α-Ca 3 (PO 4 ) 2 Put the powder into the KOH solution, seal the mouth of the beaker with a plastic wrap, place it in an oven, take it out of the oven after 3 days, filter it with suction, wash it, and dry it to obtain potassium-containing hydroxyapatite powder.

[0025] Among them, the Ca(NO 3 ) 2 and H 3 PO 4 The molar ratio is 3:1. The crucible is a corundum crucible. The temperature of the high-temperature calcination is 1300° C., and the calcination time is 3 hours. The temperature of the oven is 120°C. The stirring speed is 100r / min, and the stirring time is 25min. Pass th...

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PUM

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Abstract

The invention relates to the technical field of functional materials, in particular to a method for preparing potassium-containing hydroxyapatite powder. The method for preparing the potassium-containing hydroxyapatite powder includes the steps that a certain amount of Ca(NO3)2 and a certain amount of H3PO4 are weighed in the molar ratio of 3:2, the Ca(NO3)2 and the H3PO4 are dissolved into 300 mL of distilled water respectively, then two solutions are mixed, stirred for a period, drawn, filtered, centrifuged and dried, and Ca3(PO4)2 powder is prepared; the powder is put into a corundum crucible and calcined for 2 h at the high temperature of about 1,300 DEG C, then the product is taken out of a furnace immediately and cooled to be at the room temperature, and the alpha-Ca3(PO4)2 powder is obtained; a KOH solution is prepared, then the alpha-Ca3(PO4)2 powder is put into the KOH solution respectively, a beaker opening is sealed with a preservative film, a bearer is put into a drying oven, the temperature is set as 120 DEG C, the product is taken out of the drying oven after 3 days, drawn, filtered, repeatedly washed and dried, and the potassium-containing hydroxyapatite powder is obtained. According to the experiment, as the chemical precipitation method is adopted, the requirement of the reaction temperature is low, the purity of the synthetic product is high, particles are fine, the operating process is simple, the synthetic cost is low, and industrial production is facilitated.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a method for preparing potassium-containing hydroxyapatite powder. Background technique [0002] At present, hydroxyapatite (HAP) has been widely used as a bone graft material. It can hydrogen bond with carbohydrates and proteins on the surface of human cells, and has no toxicity to somatic cells. It has superior biological activity and ideal composition. Bone activity, with the general deepening of research, nano-hydroxyapatite is getting more and more attention in stomatology. For example, nano-hydroxyapatite toothpaste is a mild dentifrice, which not only does not cause tooth wear, but also can effectively To prevent teeth bleeding and other problems. [0003] With the change of people's living environment, dentin hypersensitivity has become a common oral disease. Common oral care products on the market are mainly chemical additives added to toothpaste. Long-term...

Claims

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Application Information

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IPC IPC(8): C01B25/32A61K8/24A61Q11/00A61P1/02A61P37/08
CPCC01B25/32A61K8/24A61Q11/00
Inventor 王耀斌
Owner SHAANXI SHENGMAI PETROLEUM
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