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Method for preparing ring opening product of epoxide by adopting microreaction device

A technology of epoxy compound and micro-reaction device, which is applied in chemical instruments and methods, organic compound/hydride/coordination complex catalyst, ether preparation, etc. Inaccurate control and other problems, to avoid the use of complex catalysts, short reaction residence time, and high safety

Active Publication Date: 2017-02-22
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in the process of kettle reaction, the ring-opening reaction of epoxy compounds participated by acid anhydrides requires complex and expensive catalyst preparation, difficulty in catalyst separation, low degree of automation of the preparation process and inaccurate temperature control during the reaction process, resulting in increased side reactions. and other problems, resulting in lower product quality and lower process safety

Method used

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  • Method for preparing ring opening product of epoxide by adopting microreaction device

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Effect test

Embodiment 1

[0027] Cyclohexane epoxy and acetic anhydride are mixed by a micro-mixer, injected into a packed micro-reactor filled with a solid catalyst HY zeolite, and reacted at 100°C for 8 minutes, wherein the molar ratio of the epoxy compound anhydride is 1:2, and the catalyst The molar ratio to epoxy compound is 0.02:1, and the output of the packed microreactor is passed through NaCO 3 Solution washing, water washing, and drying over anhydrous sodium sulfate, the epoxy compound ring-opened product was obtained, and the conversion rate of the raw material was 87%.

Embodiment 2

[0029] Epoxycyclohexane and propionic anhydride are mixed by a micro-mixer, injected into a packed micro-reactor filled with a solid catalyst HY zeolite, and reacted at 110°C for 10 minutes, wherein the molar ratio of the epoxy compound anhydride is 1:2, and the catalyst The molar ratio to epoxy compound is 0.02:1, and the output of the packed microreactor is passed through NaCO 3 Solution washing, water washing, and drying over anhydrous sodium sulfate, the epoxy compound ring-opened product is obtained, and the conversion rate of the raw material is 85%.

Embodiment 3

[0031] Epoxycyclohexane and butyric anhydride are mixed by a micro-mixer, injected into a packed micro-reactor filled with a solid catalyst HY zeolite, and reacted at 120°C for 10 minutes, wherein the molar ratio of the epoxy compound anhydride is 1:2, and the catalyst The molar ratio to epoxy compound is 0.03:1, and the output of the packed microreactor is passed through NaCO 3 Solution washing, water washing, and drying over anhydrous sodium sulfate, the epoxy compound ring-opened product is obtained, and the conversion rate of the raw material is 85%.

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Abstract

The invention discloses a method for preparing a ring opening product of an epoxide by adopting a microreaction device. The epoxide and acid anhydride are pumped into a micromixer of the microreaction device respectively at the same time and sufficiently mixed, a mixture is introduced into a microreactor of the microreaction device and subjected to sufficient reaction, a discharged product is washed and dried, and the ring opening product of the epoxide is obtained, wherein a catalyst is supported in the microreactor. Compared with the prior art, the catalyst which is low in cost, simple, available and easy to separate is used, the preparation process is simple and easy to control, and the product yield is high.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a method for preparing ring-opening products of epoxy compounds by utilizing a micro-reaction device. Background technique [0002] A series of ester compounds can be prepared through the ring-opening reaction of epoxy compounds and acid anhydrides, and these ester compounds have been widely used in the fields of solvents, plasticizers, surfactants and polymer monomers. For example, CN201210487239.7 discloses a method for preparing propylene glycol monomethyl ether acetate through a two-step coupling reaction, using propylene oxide, methanol and methyl acetate as raw materials, and undergoing ring-opening reaction and transesterification reaction to generate propylene glycol monomethyl ether acetate. Methyl ether acetate. The acetate is a high-grade industrial solvent with low toxicity and excellent performance, and has a good dissolution effect on polar and non-pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/02C07C43/184C07C43/164C07C43/12C07C43/06B01J29/08B01J31/04B01J31/02
CPCC07C41/02B01J29/088B01J31/0239B01J2231/48C07C43/184C07C43/164C07C43/126C07C43/06
Inventor 郭凯何伟方正欧阳平凯
Owner NANJING TECH UNIV
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