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A preparation method of controllable degradation o-carboxymethyl cinnamaldehyde modified chitosan antibacterial film

A technology of carboxymethyl chitosan and carboxymethyl meat is applied in the field of preparation of controllable degradation O-carboxymethyl cinnamaldehyde modified chitosan antibacterial film, and can solve the problem that film materials cannot be prepared and the degradation rate is uncontrollable , complex production process and other problems, to achieve the effect of easy availability of raw materials, excellent application value, and simple preparation method

Active Publication Date: 2019-05-28
南通药享科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the degradation performance is very good, its disadvantages are: the air permeability of the membrane is poor, the degradation rate is uncontrollable, due to the three-layer composite, the production process is complicated and thinner membrane materials cannot be prepared

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Preparation of carboxymethyl chitin

[0057] 5g of chitin was swelled in 50mL of isopropanol at room temperature for 2h, then cooled in an ice-salt bath at -2°C, slowly added 30mL of 50% NaOH solution dropwise, stirred evenly, and continued to swell at -2°C for 2h. 10g of chloroacetic acid was dissolved in 10mL of isopropanol by heating in a water bath, slowly added dropwise to the chitin solution with stirring, and stirred in a water bath at 50°C for 4h. Settled by centrifugation, poured out the supernatant, added 45mL of distilled water and 10% hydrochloric acid solution to neutral pH, filtered with suction, washed with 75% methanol and 95% ethanol, and dried in vacuum for 12 hours.

[0058] (2) Deacetylation of carboxymethyl chitin to prepare O-carboxymethyl chitosan

[0059] Take 2.5 g of the product obtained in (1), dissolve it in 50 mL of 50% NaOH solution, stir at 50°C for 1 hour, add 10 mL of deionized water, stir with suction, wash with absolute ethanol fo...

Embodiment 2

[0065] (1) Preparation of carboxymethyl chitin

[0066] 5g of chitin was swelled in 45mL of isopropanol at room temperature for 3h, then cooled in an ice-salt bath at -5°C, slowly added 30mL of 50% NaOH solution dropwise, stirred evenly, and continued to swell at -5°C for 2h. 9g of chloroacetic acid was dissolved in 9mL of isopropanol by heating in a water bath, slowly added dropwise to the chitin solution with stirring, and stirred in a water bath at 50°C for 5h. Settled by centrifugation, poured out the supernatant, added 43mL of distilled water and 10% hydrochloric acid solution to adjust the pH to neutral, filtered with suction, washed with 75% methanol and 95% ethanol respectively, and dried in vacuum for 12 hours.

[0067] (2) Deacetylation of carboxymethyl chitin to prepare O-carboxymethyl chitosan

[0068] Take 2.5 g of the product obtained in (1), dissolve it in 50 mL of 50% NaOH solution, stir at 50°C for 1 hour, add 10 mL of deionized water, stir with suction, wash...

Embodiment 3

[0074] (1) Preparation of carboxymethyl chitin

[0075] 5g of chitin was swelled in 50mL of isopropanol at room temperature for 2h, then cooled in an ice-salt bath at -3°C, slowly added 30mL of 50% NaOH solution dropwise, stirred evenly, and continued to swell at -3°C for 1h. 8g of chloroacetic acid was dissolved in 8mL of isopropanol by heating in a water bath, slowly added dropwise to the chitin solution with stirring, and stirred in a water bath at 50°C for 4.5h. Settled by centrifugation, poured out the supernatant, added 41mL of distilled water and 10% hydrochloric acid solution to adjust the pH to neutral, filtered with suction, washed with 75% methanol and 85% ethanol respectively, and dried in vacuum for 12 hours.

[0076] (2) Deacetylation of carboxymethyl chitin to prepare O-carboxymethyl chitosan

[0077] Take 2.5g of the product obtained in (1), dissolve it in 50mL of 50% NaOH solution, stir at 50°C for 2h, add 10mL of deionized water to stir, filter with suction,...

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Abstract

The invention discloses a preparation method of a controllably degraded O-carboxymethyl cinnamaldehyde-modified chitosan antibacterial film. The preparation method comprises (1) preparation of carboxymethyl chitin, (2) preparation of O-carboxymethyl chitosan through carboxymethyl chitin deacetylation, (3) preparation of O-carboxymethyl cinnamaldehyde-modified chitosan, and (4) preparation of the controllably degraded antimicrobial film. The controllably degraded film has salmonella, escherichia coli, staphylococcus aureus and aspergillus niger inhibition activity better than those of single chitosan and the traditional cinnamaldehyde-modified chitosan antibacterial film, has good physical properties and breathability and a controllable degradation rate, can be widely used in fields of agriculture, medicines and food packaging preservation and antibiosis. The preparation method is simple, is easy to operate and has good practicability.

Description

technical field [0001] The invention belongs to the field of preparation of medical antibacterial films, in particular to a preparation method for controllable degradation of O-carboxymethylcinnamaldehyde modified chitosan antibacterial films. Background technique [0002] Chitin is a natural polymer whose biosynthesis amount is second only to cellulose in nature. Its main source is the shell of crustaceans such as shrimps and crabs and the cell walls of some fungi and algae. It is the only alkaline cationic polymer that exists in large quantities in nature. polysaccharides. Chitin has good physiological adaptability and biodegradability, and is an important class of biomedical materials. However, due to its poor solubility, chitin is generally modified, and the most common method is to generate chitosan through deacetylation. [0003] Cinnamaldehyde is an aldehyde compound, a yellow liquid, which is abundant in cinnamon and other plants. Natural products mainly exist in c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L91/00C08K5/07C08J5/18C08B37/08
CPCC08B37/003C08J5/18C08J2305/08C08J2491/00C08L5/08C08L2201/06C08L2203/16C08L2205/03C08L91/00C08K5/07
Inventor 侯昭升尹胜男刘小龙张娜
Owner 南通药享科技有限公司
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