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External aerosol containing desonide

A technology of desonide and aerosol, which is applied in the field of external aerosol containing desonide to achieve the effect of large spraying area, improved curative effect and convenient operation

Inactive Publication Date: 2017-03-08
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the stability of the above-mentioned existing product and the problem of product content uniformity are also one of the problems to be solved in the development of desonide aerosol

Method used

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  • External aerosol containing desonide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 desonide aerosol of the present invention

[0031] The composition of desonide aerosol prescription of the present invention:

[0032] project Material mass percentage material quantity Desonide 0.05％ 0.5g Absolute ethanol 15.0％ 150.0g HFA-134a 84.95％ 849.5g Total 100.00％ 1000.0g

[0033] Preparation method: mix desonide, absolute ethanol, and propellant HFA 134a according to the prescription amount and stir thoroughly to form a solution, and quantitatively pour the solution into an aerosol bottle with a 50 μl quantitative special valve that has been grasped and sealed by pressurized filling , that is.

Embodiment 2

[0034] Embodiment 2 Preparation of desonide aerosol of the present invention

[0035] The composition of desonide aerosol prescription of the present invention:

[0036] Material mass percentage material quantity Desonide 0.05％ 0.5g Absolute ethanol 10.00％ 100.0g Oleic acid 0.30％ 3.0g HFA-227 89.65％ 896.5g Total 100.00％ 1000.0g

[0037] Preparation method: mix desonide, absolute ethanol, oleic acid and propellant HFA-227 according to the prescription amount and stir well to form a solution, and quantitatively pour the solution into a 50 μl quantitative special valve that has been grasped and sealed by pressurized filling. Available in an aerosol bottle.

Embodiment 3

[0038] Embodiment 3 Preparation of desonide aerosol of the present invention

[0039] The composition of desonide aerosol prescription of the present invention:

[0040] Material mass percentage material quantity Desonide 0.05％ 0.5g Propylene Glycol 3.98％ 39.8 Oleic acid 0.52％ 5.2g HFA-134a 95.45％ 954.5g Total 100.00％ 1000.0g

[0041] Preparation method: mix desonide, propylene glycol, oleic acid and propellant HFA-134a according to the prescription amount and stir well to form a solution, and quantitatively pour the solution into the aerosol with a 50 μl quantitative special valve that has been grasped and sealed by pressurized filling In a bottle, ready to serve.

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Abstract

The invention belongs to the field of drug preparations and relates to a drug preparation containing desonide, in particular to an external aerosol containing desonide. A content drug of the desonide aerosol is a desonide drug stable in quality and containing desonide micropowder. The desonide aerosol consists of the following components in percentage by weight: 0.05-0.2% of the desonide micropowder and the balance of pharmaceutically acceptable auxiliary materials. The desonide aerosol is directly sprayed to an action part, is distributed uniformly and quickly takes effect, and due to the use method of direct spraying, the contact with microorganisms is reduced; and a closed lightproof storage container avoids contact with water and oxygen in air, so that the drug stability is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a pharmaceutical preparation containing desonide, in particular to an external aerosol containing desonide. Background technique [0002] Desonide is a weak glucocorticoid drug in the genus, which has anti-inflammatory, anti-allergic, antipruritic and anti-exudation effects; by affecting the transcription of some genes involved in inflammation, it can reduce and prevent tissue responses to inflammation and eliminate local inflammation. Heat, redness, and swelling caused by non-infectious inflammation, thereby reducing the manifestations of inflammation; has an immunosuppressive effect: prevent or inhibit cellular immune responses, and inhibit the initial immune response. The topical preparations of desonide can be used for the treatment of various hormone-sensitive skin diseases such as contact dermatitis, neurodermatitis, seborrheic dermatitis, eczema, psoriasis, lichen ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/08A61K9/10A61K31/58A61P17/00A61P17/08A61P17/06A61P17/04A61P25/00
Inventor 传娜陈李平管璐晗陈博赵静
Owner CHONGQING HUAPONT PHARMA
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