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Multifunctional nano probe, and preparation method and application thereof

A nano-probe, multi-functional technology, applied in general/multi-functional contrast agents, pharmaceutical formulations, photodynamic therapy, etc., to achieve the effects of cheap source of raw materials, controllable morphology, and simple preparation process

Inactive Publication Date: 2017-03-15
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no single modality imaging can provide all necessary information for disease diagnosis and treatment

Method used

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  • Multifunctional nano probe, and preparation method and application thereof
  • Multifunctional nano probe, and preparation method and application thereof
  • Multifunctional nano probe, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of multifunctional nanoprobes with MRI / photoacoustic dual-modal imaging and photothermal / photodynamic therapy:

[0028] (1) Fe@Fe 3 Ge 2 Preparation of nanoparticles:

[0029] Add 110mg GeI4, 18mL OAm, 1.8mL OA, 25mg HDA·HCl into a three-neck flask, sonicate until colorless, degas, raise the temperature to 115°C, and keep for 40min. After cooling to 75°C, 1.8 mL of HMDS was added. Raise the temperature to 225°C at 10°C / min, add 90μL Fe(CO)5, and keep this temperature for 28min. Then add 30μL Fe(CO) 5 , heated up to 270°C and kept for 35min. Centrifuge twice with ethanol to obtain oil-soluble Fe@Fe 3 Ge 2 Nanoparticles.

[0030] (2) Preparation of MNPs-DSPE-PEG nanoprobes:

[0031] Take 12mg DSPE-PEG and dissolve it in chloroform, add 6mg MNPs (that is, the Fe@Fe prepared in step (1) 3 Ge 2 Nanoparticles), shaker for 12h, rotary steaming, add 3-5mL of secondary water.

[0032] Depend on figure 1 It can be seen from the TEM electron microscope fig...

Embodiment 2

[0034] Preparation of multifunctional nanoprobes with MRI / photoacoustic dual-modal imaging and photothermal / photodynamic therapy:

[0035] (1) Fe@Fe 3 Ge 2 Preparation of nanoparticles:

[0036] Add 100mg GeI4, 15mL OAm, 1.5mL OA, 20mg HDA·HCl into a three-neck flask, sonicate until colorless, degas, heat up to 110°C, and keep for 30min. After cooling to 70°C, 1.5 mL of HMDS was added. Raise the temperature to 220°C at 10°C / min, add 90μL Fe(CO)5, and keep this temperature for 20min. Then add 30μL Fe(CO) 5 , heated up to 260°C and kept for 30min. Centrifuge once with ethanol to obtain oil-soluble Fe@Fe 3 Ge 2 Nanoparticles.

[0037] (2) Preparation of MNPs-DSPE-PEG nanoprobes:

[0038] Take 10mg DSPE-PEG dissolved in chloroform, add 10mL Fe@Fe with a concentration of 0.5mg / mL 3 Ge 2 Nanoparticle solution Chloroform solution, shake the bed overnight at room temperature, remove chloroform by rotary evaporation at room temperature, then rotary steam in a water bath at 8...

Embodiment 3

[0040] Preparation of multifunctional nanoprobes with MRI / photoacoustic dual-modal imaging and photothermal / photodynamic therapy:

[0041] (1) Fe@Fe 3 Ge 2 Preparation of nanoparticles:

[0042] Add 120mg GeI4, 20mL OAm, 2mL OA, 30mg HDA·HCl to a three-neck flask, sonicate until colorless, degas, heat up to 120°C, and keep for 50min. After cooling to 80°C, 2 mL of HMDS was added. Heat up to 230°C at 10°C / min, add 90μL Fe(CO) 5 , keep this temperature for 30min. Then add 30μL Fe(CO) 5 , heated up to 280°C and kept for 40min. Centrifuge 3 times with ethanol to obtain oil-soluble Fe@Fe 3 Ge 2 Nanoparticles.

[0043] (2) Preparation of MNPs-DSPE-PEG nanoprobes:

[0044] Take 15mg DSPE-PEG dissolved in chloroform, add 10mL of Fe@Fe with a concentration of 1mg / mL 3 Ge 2 Nanoparticle solution Chloroform solution, shake the bed overnight at room temperature, remove chloroform by rotary evaporation at room temperature, then rotary steam in a water bath at 80°C for 1min, the...

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Abstract

The invention relates to a multifunctional nano probe for MRI (magnatic resonance imaging) / optoacoustic imaging bimodal image and photothermal / photodynamic therapies, and preparation and application thereof. The nano probe is composed of Fe@Fe3Ge2 nanoparticles and liposome DSPE-PEG (distearoyl-phosphatidylethanolamine-polyethylene glycol) coupled on the surface of the Fe@Fe3Ge2 nanoparticles. The preparation method comprises the following steps: dissolving the DSPE-PEG into an organic solvent, adding the Fe@Fe3Ge2 nanoparticle solution, and uniformly mixing to obtain the MNPs-DSPE-PEG nano probe. The nano probe MNPs-DSPE-PEG has favorable photothermal and photodynamic effects, and can be used for optoacoustic imaging and MRI. Compared with the prior art, the probe has favorable photothermal / photodynamic effects and imaging effects, and can perform multiple image therapies on one molecule.

Description

technical field [0001] The invention relates to a multifunctional nanoprobe, in particular to a multifunctional nanoprobe with MRI / photoacoustic dual-mode imaging and photothermal / photodynamic therapy and its preparation and application. Background technique [0002] Molecular imaging (MI) was first proposed by Weissleder of Harvard University. The technologies currently used in molecular imaging research include CT, MRI, US, PET, SPECT, and photoacoustic imaging. However, no single modality imaging can provide all the necessary information for disease diagnosis and treatment. In view of the advantages and disadvantages of each single modality imaging, in recent years, dual (multi) modality molecular imaging has gradually become a research and development hotspot, and it has also driven the development and construction of dual (multi) modality molecular probes. Nanotechnology provides a platform for the construction of ideal dual (multi)modal molecular probes, and the resea...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12A61K49/10A61K49/22A61K41/00
CPCA61K41/0052A61K41/0057A61K49/0002A61K49/10A61K49/126A61K49/1812A61K49/221A61K49/227
Inventor 杨仕平潘立星阎聪洋张晓芬赵恒
Owner SHANGHAI NORMAL UNIVERSITY
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