A method for connection between magnesium alloy and silk fibroin

A technology of silk fibroin and magnesium alloy, which can be used in pharmaceutical formulations, prostheses, drug delivery, etc., can solve problems such as unstable physical connections, and achieve the effect of stable combination and ease of degradation

Active Publication Date: 2019-03-26
HARBIN INST OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only unstable physical connections can be formed directly between inorganic materials and organic biomacromolecules

Method used

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  • A method for connection between magnesium alloy and silk fibroin
  • A method for connection between magnesium alloy and silk fibroin
  • A method for connection between magnesium alloy and silk fibroin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This embodiment provides a low-temperature connection method between magnesium alloy and silk fibroin by using APTES, and the specific implementation steps are as follows:

[0035] (1) Polishing: A magnesium alloy with a diameter of 10 mm and a thickness of 2 mm was mechanically polished.

[0036] (2) Cleaning: Put the polished magnesium alloy into an acetone solution with a volume concentration of 70% and perform ultrasonic cleaning at a temperature of 25°C; then rinse with ethanol and deionized aqueous solution for 3 min respectively.

[0037] (3) Initial modification of magnesium alloy surface: ① Take a certain volume of APTES solution and pour it into a certain volume of toluene solution to prepare an APTES toluene solution with a volume concentration of 2%; ② Put the above magnesium alloy into the prepared APTES toluene Soak in the solution for 10 h, the soaking temperature is room temperature, and use silane coupling agent to modify the surface of magnesium alloy....

Embodiment 2

[0047] This embodiment provides a low-temperature connection method between magnesium alloy and silk fibroin by using methyltriethoxysilane, and the specific implementation steps are as follows:

[0048] (1) Polishing: A magnesium alloy with a diameter of 10 mm and a thickness of 2 mm was mechanically polished.

[0049] (2) Cleaning: Put the polished magnesium alloy into an acetone solution with a volume concentration of 70% and perform ultrasonic cleaning at a temperature of 25°C; then rinse with ethanol and deionized aqueous solution for 3 min respectively.

[0050] (2) Initial modification of magnesium alloy surface: ① Take a certain volume of methyltriethoxysilane solution and pour it into a certain volume of toluene solution to prepare a methyltriethoxysilane toluene solution with a volume concentration of 2%; ② Soak the above-mentioned magnesium alloy in the prepared methyltriethoxysilane toluene solution for 10 h at room temperature, and modify the surface of the magnes...

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Abstract

The invention discloses a method for connecting magnesium alloy with silk fibroin. The method comprises the following steps to connect the magnesium alloy with the silk fibroin: washing the surface of the magnesium alloy, modifying the surface of the magnesium alloy by using a silane coupling agent, coating the surface of the magnesium alloy with a silk fibroin solution, and performing drying treatment. By adopting the method, stable chemical connection of an inorganic material with organic biological macromolecules is realized, the connection temperature is relatively low, and original physical and chemical properties of the silk fibroin are not damaged. By adopting the method, the mechanical properties and biocompatibility of the magnesium alloy are not affected; and due to the structure that the magnesium alloy is coated by the silk fibroin, degradation of the magnesium alloy in body fluid or tissue fluid can be effectively retarded.

Description

technical field [0001] The invention belongs to the technical field of material connection, and relates to a connection method between inorganic materials and organic biomacromolecules, in particular to a low-temperature connection method used between magnesium alloy and silk fibroin. Background technique [0002] Magnesium alloy is one of the important biomedical materials, has good biocompatibility, and is one of the constant elements of the human body. Compared with other medical metal materials (such as stainless steel, cobalt-based alloys, titanium alloys, etc.), it can effectively avoid The low newborn bone strength caused by the "stress shielding effect" and the economic and mental burden of the second operation on the patient. However, since the degradation rate of magnesium alloy in the body is faster than the repair rate of bone tissue, it has been unable to carry out a wider application in the field of biomedical materials. As a kind of protein, silk fibroin deg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/22A61L27/50
CPCA61L27/047A61L27/227A61L27/50A61L2400/18A61L2430/02C08L89/00
Inventor 王晨曦王岩松孙亚汝
Owner HARBIN INST OF TECH
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