Amyrin cinnamate extract and preparation method thereof

A technology of cinnamic acid ester and balsamic resin alcohol, which is applied in the field of balsamic resin alcohol cinnamic acid ester extract and its preparation, can solve the problems of lack of research, etc., and achieve the effect of simple solvent preparation, high paste yield and short time

Active Publication Date: 2017-03-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic and foreign researches are limited to the research on the leaves of Gymnema sylvestris, and there are not many research reports on its

Method used

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  • Amyrin cinnamate extract and preparation method thereof
  • Amyrin cinnamate extract and preparation method thereof
  • Amyrin cinnamate extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A balsamole cinnamate extract from Gymnema syringae fruit.

[0028] The preparation method of balsamol cinnamon extract, comprises the following specific steps:

[0029] (1) Preparation of extract: take fresh Gymnema fruit and dry it in the sun successively until the water content is 5%, and grind it until the particle size is 2mm to obtain Gymnema fruit coarse powder, according to the usage amount of Gymnema fruit coarse powder The mass ratio of the usage amount of 70% ethanol is 1:10, then weigh a spoonful of Gymnema fruit coarse powder, add 70% ethanol to soak for 24h, and then carry out reflux extraction 20 times, each time for 60min, then collect the extract to obtain a crude extract After recovering the ethanol under reduced pressure, the crude extract was concentrated and dried to obtain the extract;

[0030] (2) Preparation of extracts in various parts: after stirring the extracts obtained above with 200 mesh silica gel, then using sherwood oil, ethyl acetate, ...

Embodiment 2

[0034] A balsamole cinnamate extract from Gymnema syringae fruit.

[0035] The preparation method of balsamol cinnamon extract, comprises the following specific steps:

[0036] (1) Preparation of extract: take fresh Gymnema fruit and dry it in the sun successively until the moisture content is 4%, and grind it to a particle size of 5 mm to obtain Gymnema fruit meal, according to the usage amount of Gymnema fruit meal The mass ratio of the amount used with 70% ethanol is 1:15, then weigh a spoonful of Gymnema fruit powder, add 70% ethanol to soak for 30 hours, and then carry out reflux extraction for 30 times, each time for 90 minutes, and then collect the extract to obtain a crude extract After recovering the ethanol under reduced pressure, the crude extract was concentrated and dried to obtain the extract;

[0037] (2) Preparation of extracts in various parts: after stirring the above-mentioned extracts with particle diameter of 300 meshes of silica gel, then use sherwood oi...

Embodiment 3

[0041] A balsamole cinnamate extract from Gymnema syringae fruit.

[0042] The preparation method of balsamol cinnamon extract, comprises the following specific steps:

[0043] (1) Preparation of extract: take fresh Gymnema fruit and dry it in the sun successively until the moisture content is 3%, and grind it until the particle size is 3mm to obtain Gymnema fruit coarse powder, according to the usage amount of Gymnema fruit coarse powder The mass ratio of the amount used with 70% ethanol is 1:13, then weigh a spoonful of Gymnema fruit powder, add 70% ethanol to soak for 22 hours, and then carry out reflux extraction for 22 times, each time for 65 minutes, and then collect the extract to obtain a crude extract After recovering the ethanol under reduced pressure, the crude extract was concentrated and dried to obtain the extract;

[0044] (2) Preparation of extracts in various parts: after stirring the extracts obtained above with a particle size of 250 mesh silica gel, then u...

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Abstract

The invention discloses an amyrin cinnamate extract and a preparation method thereof. The amyrin cinnamate extract is prepared from gymnema sylvestre fruit. The preparation method of the amyrin cinnamate extract comprises the following specific steps of (1) preparation of extract; (2) preparation of extract in all positions; (3) obtaining of the amyrin cinnamate extract: taking the extract in the position of petroleum ether, separating by using silica gel column chromatography, carrying out gradient elution by using petroleum ether-ethyl acetate as an eluting agent, obtaining a yellow oily matter in a 40 to 1 eluting part, and at least repeatedly carrying out four times of recrystallization by using acetone after washing off the yellow oily matter from a solution by using the petroleum ether, thus obtaining white feather-like crystals, i.e., a compound-the amyrin cinnamate extract. According to the amyrin cinnamate extract and the preparation method of the amyrin cinnamate extract, disclosed by the invention, the ingredient of amyrin cinnamate is extracted from the gymnema sylvestre fruit for the first time, the preparation method is simple and easy to operate, and the obtained total extract yield is up to 12.18 percent to 12.93 percent.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an extract of balsamol cinnamon and a preparation method thereof. Background technique [0002] Gymnema sp. is a plant of the genus Gymnema in the family Acidaceae, also known as gymnastics, horn, and King Kongteng. It is widely distributed in Guangdong, Guangxi, Fujian, Taiwan, and Yunnan provinces in my country. It is also distributed in India, Indonesia, Africa, and Vietnam. It is flat in nature and bitter in taste, and the whole plant can be used as medicine, which has the effects of clearing away heat and detoxifying, promoting granulation and reducing swelling, dispelling wind and relieving pain. Modern pharmacological studies have shown that Gymnema syringae has the functions of lowering blood sugar, lowering blood fat, anti-caries, inhibiting sweet reaction, anti-virus, and anti-allergy. It has been developed into anti-diabetic drugs such...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/56A61P29/00
CPCA61K36/27C07B2200/13C07J63/008
Inventor 丘琴甄丹丹陈明伟姜建萍甄汉深丘奕定黄小秋黄培倩
Owner GUANGXI UNIV OF CHINESE MEDICINE
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