Synthetic method of antitumor drug 6-hydroxy seleninic acid esterification chitosan copper

A technology of hydroxy selenite and chitosan copper, which is applied in the fields of biomedical engineering and fine chemical industry, can solve the problems such as the inability to obtain a single 6-OH selenite esterified compound, etc. absorption effect

Inactive Publication Date: 2017-03-22
HUBEI UNIVERSITY OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But according to Chinese invention patent CN1685831A, the preparation method [P] of chitosan metal-copper composite antibacterial agent [P] prepared or

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0014] The synthesis of example 1, chitosan copper

[0015] Chitosan copper is synthesized according to the method of literature, and chitosan monomer and Cu in its molecule 2+ The molar ratio is 1:1.

example 2

[0016] Example 2, the synthesis of selenite esterified chitosan copper

[0017] The chitosan copper powder that will comprise 10mmol chitosan monomer is dissolved in the aqueous solution of 100ml 1% formic acid or acetic acid, add the water that 10ml is dissolved with 10mmol selenous acid under stirring, control reaction temperature 75-90 o C. Heating and stirring for 2-3 hours until the selenous acid reaction is complete to obtain a selenite-esterified chitosan copper solution, add ethanol until no precipitation occurs, filter, wash with 75% ethanol for 2-3 times, and dry Get the pure product of selenite esterified chitosan copper, chitosan monomer in the product molecule synthesized by this method: Cu 2+ : Se atom = 1:1:1 (molar ratio).

[0018] The selenized chitosan copper that this above-mentioned method is synthesized is that the 6-OH of chitosan monomer is carried out selenite esterification alone, has reached both improving selenized chitosan water-solubility, and doe...

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PUM

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Abstract

The invention relates to a synthetic method of an antitumor drug 6-hydroxy seleninic acid esterification chitosan copper. According to the invention, 6-OH is subjected to seleninic acid esterification by a chitosan copper monomer, the chitosan copper is dissolved in an acid solution, the material is added in an seleninic acid aqueous solution, wherein the mol ratio of the chitosan monomer and seleninic acid in the chitosan copper is 1:1, the reaction temperature is controlled between 75-90 DEG C, heating and stirring can be carried out for 2-3 hours to obtain a seleninic acid esterification chitosan copper aqueous solution, ethanol is added until no precipitate is added, the material is filtered, ethanol with concentration of 75% is used for washing for 2-3 times, and drying is carried out to obtain the seleninic acid esterification chitosan copper pure product; and wherein an acid solution is a formic acid or acetic acid aqueous solution with concentration of 1%. The seleninic acid esterification chitosan copper is a preparation which has the advantages of no harm on environment, no toxic and side effect, easy absorption, and containing of selenium and trace element copper, can be taken as a novel selenium and trace element supplement preparation used for the fields of medicine, a health product, a cosmetic and agriculture, and can be taken as the novel antitumor drug.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and also belongs to the technical field of fine chemical industry. Specifically, it relates to a method for synthesizing copper chitosan esterified with 6-hydroxy selenite, an antitumor drug. , a chitosan derivative with antitumor activity that is easy to produce. Background technique [0002] Chitosan [β(1,4)-2-amino-2-deoxy-D-glucose] is an alkaline biological polysaccharide, which is positively charged under acidic conditions, and can discharge with anions on the surface of tumor cells through adsorption Neutralize, resist its growth, have anti-tumor, anti-inflammatory, antibacterial and other biological activities, and have good biocompatibility, almost non-toxic, and no other adverse reactions. It is often used as a good drug material in modern drug synthesis. develop and expand its scope of application. [0003] . [0004] Selenium is one of the essential trace elements ...

Claims

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Application Information

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IPC IPC(8): C08B37/08A61K31/722A61P35/00
CPCA61K31/722C08B37/003
Inventor 曾小华王红梅邓守恒汪选斌
Owner HUBEI UNIVERSITY OF MEDICINE
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