Cinnamate type ultraviolet sun-screening agent molecular engram solid-phase extraction column as well as preparation and application thereof

A cinnamic acid ester and solid phase extraction column technology, which is applied in the direction of solid adsorbent liquid separation, material separation, and material analysis, can solve the problems of high extraction recovery rate and poor packing selectivity, and achieve high extraction recovery rate and adsorption Powerful, time-saving and energy-saving effects

Inactive Publication Date: 2017-04-26
SHANGHAI JIAO TONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a molecularly imprinted solid-phase extraction column for cinnamate ultraviolet sunscreens and its preparation method and application, so as to overcome the shortcomings of poor selectivity of traditional solid-phase extraction fillers. The cinnamate ultraviolet sunscreen of the present invention Molecularly imprinted solid-phase extraction column can selectively adsorb cinnamic acid ester UV sunscreen. Compared with conventional solid-phase extraction, it has strong adsorption capacity and high extraction recovery rate, and realizes the detection of trace cinnamic acid in various environments and biological samples. Efficient and selective separation, enrichment and purification of ester UV sunscreens

Method used

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  • Cinnamate type ultraviolet sun-screening agent molecular engram solid-phase extraction column as well as preparation and application thereof
  • Cinnamate type ultraviolet sun-screening agent molecular engram solid-phase extraction column as well as preparation and application thereof
  • Cinnamate type ultraviolet sun-screening agent molecular engram solid-phase extraction column as well as preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033]Dissolve 0.2mmol template molecule octyl p-methoxycinnamate and 0.8mmol functional monomer methacrylic acid in 30mL porogen chloroform, ultrasonically oscillate for 5min until mixed evenly, add 4mmol crosslinking agent ethylene glycol dimethacrylate and 25 mg of initiator azobisisobutyronitrile, ultrasonically disperse and mix, blow nitrogen to deoxygenate to ensure the smooth progress of the polymerization reaction, seal and react in a water bath at 40-60°C under rotating conditions to obtain microspherical molecularly imprinted polymers. The above polymer was wrapped with slow quantitative filter paper, placed in a Soxhlet extractor and extracted with a mixed solution of formic acid and methanol with a volume ratio of 5:95, the extraction time was 48 hours, and the temperature of the water bath was 80°C to remove template molecules and Unreacted compounds are then eluted alternately with base (mixed solution of methanol and water with a volume ratio of 1:1 containing 0....

Embodiment 2

[0035] The difference from Example 1 is that the functional monomer methacrylic acid in Example 2 is 0.2 mmol.

Embodiment 3

[0037] The difference from Example 1 is that the functional monomer methacrylic acid in Example 3 is 1.6 mmol.

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Abstract

The invention relates to a cinnamate type ultraviolet sun-screening agent molecular engram solid-phase extraction column as well as preparation and application thereof, and belongs to the technical field of solid-phase extraction of detection analysis. According to the invention, iso-octyl p-methoxycinnamate is adopted as a template molecule, methacrylic acid is adopted as a functional monomer, ethylene glycol dimethyl acrylic ester is adopted as a crosslinking agent, azodiisobutyronitrile is adopted as an initiating agent, cinnamate type ultraviolet sun-screening agent molecular engram polymer microspheres are obtained by virtue of a precipitation polymerization method, and the obtained polymer microspheres are filled into a solid-phase extraction column through a wet method. The molecular engram polymer solid-phase extraction column provided by the invention can selectively adsorb a cinnamate type ultraviolet sun-screening agent, and compared with a conventional solid-phase extraction column, the molecular engram polymer solid-phase extraction column overcomes the defect of poor selectivity of a conventional solid-phase extraction filler, is strong in adsorptivity, high in extraction recovery rate, and achieves efficient selective separation, enrichment and purification of a trace amount of the cinnamate type ultraviolet sun-screening agent in various environments and biological samples.

Description

technical field [0001] The invention relates to the technical field of solid-phase extraction for detection and analysis, in particular to a molecularly imprinted solid-phase extraction column for cinnamate ultraviolet sunscreens and its preparation method and application. Background technique [0002] Organic UV sunscreens are widely added to personal care products such as sunscreens, make-up, and toiletries, and are a class of aromatic compounds that can absorb ultraviolet radiation. Even though UV sunscreens are listed as emerging pollutants, their production and use are still increasing. It is estimated that the global annual production of UV sunscreens is about 10,000 tons. Due to the large and frequent use of people, the residual amount of ultraviolet sunscreens in the environment has gradually increased, forming "pseudo-persistent pollution". Organic UV sunscreens enter the environment directly or indirectly in many different forms, but the traditional sewage treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/22B01D15/20B01J20/26B01J20/28B01J20/285B01J20/30C08F222/14C08F220/06C08J9/26C08J9/28G01N30/06G01N30/08
CPCB01D15/206B01D15/22B01J20/268B01J20/28021B01J20/285B01J2220/445B01J2220/4812B01J2220/52C08F222/1006C08F222/102C08J9/26C08J9/28C08J2201/0422C08J2335/02G01N30/06G01N30/08G01N2030/062G01N2030/065C08F220/06
Inventor 袁涛敖俊杰李丹倪霓夏慧
Owner SHANGHAI JIAO TONG UNIV
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